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01-01-2017 | Review

IL-9 and Th9 in parasite immunity

Authors: P. Licona-Limón, A. Arias-Rojas, E. Olguín-Martínez

Published in: Seminars in Immunopathology | Issue 1/2017

Abstract

Interleukin-9 is a cytokine classically related to type 2 immune responses whose cellular identity has been recently reevaluated to identify a new specialized T helper subset called Th9 and an innate source referred as innate lymphoid cell type 2. Over the past years, IL-9 has been associated with allergic responses, tumor immunology, and autoimmunity; however, in this review, we will specifically focus on the role of IL-9 and Th9 cells in the context of parasitic infections. We will summarize and discuss all the evidence relating IL-9 expression and function in parasitic infections with a particular emphasis in helminth infections, an important health issue in developing countries; we will also provide a general description and classification of parasites, the immune response and cellular compartments activated in this context, and its implications and future directions towards a complete understanding of this interesting new T helper subset and its potential therapeutic use.

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Title: IL-9 and Th9 in parasite immunity
Authors: P. Licona-Limón
A. Arias-Rojas
E. Olguín-Martínez
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 1/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0606-9

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