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Seminars in Immunopathology
Published in: Seminars in Immunopathology 5/2014

01-09-2014 | Review

Immune sensing of nucleic acids in inflammatory skin diseases

Authors: Olivier Demaria, Jeremy Di Domizio, Michel Gilliet

Published in: Seminars in Immunopathology | Issue 5/2014

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Abstract

Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus.
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Metadata
Title
Immune sensing of nucleic acids in inflammatory skin diseases
Authors
Olivier Demaria
Jeremy Di Domizio
Michel Gilliet
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 5/2014
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-014-0445-5

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