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Published in: Seminars in Immunopathology 4/2013

Open Access 01-07-2013 | Review

Molecular mechanisms regulating NETosis in infection and disease

Authors: Nora Branzk, Venizelos Papayannopoulos

Published in: Seminars in Immunopathology | Issue 4/2013

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Abstract

Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.
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Metadata
Title
Molecular mechanisms regulating NETosis in infection and disease
Authors
Nora Branzk
Venizelos Papayannopoulos
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2013
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-013-0384-6

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Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.