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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2012

01-03-2012 | Review

Exploring Staphylococcus aureus pathways to disease for vaccine development

Authors: Andrea DeDent, Hwan Keun Kim, Dominique Missiakas, Olaf Schneewind

Published in: Seminars in Immunopathology | Issue 2/2012

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Abstract

Staphylococcus aureus is a commensal of the human skin or nares and a pathogen that frequently causes skin and soft tissue infections as well as bacteremia and sepsis. Recent efforts in understanding the molecular mechanisms of pathogenesis revealed key virulence strategies of S. aureus in host tissues: bacterial scavenging of iron, induction of coagulation pathways to promote staphylococcal agglutination in the vasculature, and suppression of innate and adaptive immune responses. Advances in all three areas have been explored for opportunities in vaccine design in an effort to identify the critical protective antigens of S. aureus. Human clinical trials with specific subunit vaccines have failed, yet provide important insights for the design of future trials that must address the current epidemic of S. aureus infections with drug-resistant isolates (MRSA, methicillin-resistant S. aureus).
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Metadata
Title
Exploring Staphylococcus aureus pathways to disease for vaccine development
Authors
Andrea DeDent
Hwan Keun Kim
Dominique Missiakas
Olaf Schneewind
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 2/2012
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-011-0299-z

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