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Open Access 01-09-2009 | Review

Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis

Authors: Andrea T. Borchers, Shinji Shimoda, Christopher Bowlus, Carl L. Keen, M. Eric Gershwin

Published in: Seminars in Immunopathology | Issue 3/2009

Abstract

The mechanisms operating in lymphocyte recruitment and homing to liver are reviewed. A literature review was performed on primary biliary cirrhosis (PBC), progressive sclerosing cholangitis (PSC), and homing mechanisms; a total of 130 papers were selected for discussion. Available data suggest that in addition to a specific role for CCL25 in PSC, the CC chemokines CCL21 and CCL28 and the CXC chemokines CXCL9 and CXCL10 are involved in the recruitment of T lymphocytes into the portal tract in PBC and PSC. Once entering the liver, lymphocytes localize to bile duct and retain by the combinatorial or sequential action of CXCL12, CXCL16, CX3CL1, and CCL28 and possibly CXCL9 and CXCL10. The relative importance of these chemokines in the recruitment or the retention of lymphocytes around the bile ducts remains unclear. The available data remain limited but underscore the importance of recruitment and homing.

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Title: Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
Authors: Andrea T. Borchers
Shinji Shimoda
Christopher Bowlus
Carl L. Keen
M. Eric Gershwin
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Seminars in Immunopathology / Issue 3/2009
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-009-0167-2

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Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis

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