Published in:
01-09-2006 | Introduction
Regulatory T cells
Author:
Shimon Sakaguchi
Published in:
Seminars in Immunopathology
|
Issue 1/2006
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Excerpt
There is accumulating evidence that regulatory T cells (Tregs), once called suppressor T cells, are present in the normal immune system as an essential cellular component for maintaining immunologic self-tolerance and immune homeostasis. Their anomaly can be a cause of aberrant or excessive immune responses, including autoimmune and immunopathological diseases. This issue of Springer Seminars of Immunopathology brings together current efforts to understand how Tregs contribute to immune homeostasis and self-tolerance and how they can be exploited to control physiological and pathological immune responses. …