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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2006

01-10-2006 | Review

Apoptotic cell death and lupus

Author: Philip L. Cohen

Published in: Seminars in Immunopathology | Issue 2/2006

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Abstract

Programmed cell death and the disposal of cell corpses by phagocytic cells are highly regulated ongoing processes essential for the survival and well-being of higher organisms. Abnormalities in the susceptibility of certain cells to receptor-induced death are known to lead to certain human diseases (e.g., autoimmune lymphoproliferative syndrome) and may contribute to the pathogenesis of systemic lupus erythematosus. Impaired clearance of apoptotic cells is also likely to be an important factor in lupus pathogenesis, though the biological basis of such a defect remains elusive. Finally, the process of apoptosis has been shown to contribute to lupus disease effector mechanisms. A better understanding of the role of apoptosis in lupus very likely will lead to improved diagnosis and therapy.
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Metadata
Title
Apoptotic cell death and lupus
Author
Philip L. Cohen
Publication date
01-10-2006
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 2/2006
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-006-0038-z

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