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Seminars in Immunopathology
Published in: Seminars in Immunopathology 3-4/2004

01-02-2004 | Original Paper

The role of ICOS and other costimulatory molecules in allergy and asthma

Authors: Anthony J. Coyle, Jose-Carlos Gutierrez-Ramos

Published in: Seminars in Immunopathology | Issue 3-4/2004

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Abstract

Activation and differentiation of T cells play a critical role in the pathogenesis of allergies and asthma. Upon encounter with specific antigen, naïve T helper precursor (ThP) cells become activated, an event that is regulated not only by engagement of the T cell receptor (TCR) with peptide presented in the context of MHC class II molecules, but also by a number of costimulatory signals. CD28 engagement by B7-1 and B7-2 on resting ThP cells provides a critical signal for initial cell cycle progression, interleukin-2 production and clonal expansion. However, in recent years, other related members of the immunoglobulin (Ig) family, such as inducible costimulatory molecules (ICOS) and the TNF receptor family members which include OX40, have also been demonstrated to play an important role in providing unique and complementary signals that regulate the outcome of immune responses. These positive costimulatory signals are counterbalanced by signals that dampen down immune responses and include CTLA-4, PD-1 and the recently described Ig superfamily members BTLA and TIM-3. This review discusses the role of these costimulatory signals and their potential involvement in the pathogenesis of asthma and allergic responses.
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Metadata
Title
The role of ICOS and other costimulatory molecules in allergy and asthma
Authors
Anthony J. Coyle
Jose-Carlos Gutierrez-Ramos
Publication date
01-02-2004
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 3-4/2004
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-003-0154-y

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