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Annals of Hematology
Published in: Annals of Hematology 1/2019

01-01-2019 | Letter to the Editor

Major bleeding in a patient with warfarin-hypersensitive and factor IX propeptide variant, p.Ala37Thr, who was treated with a direct oral anti-Xa inhibitor

Authors: Asako Tamura, Hideo Wada, Makoto Ikejiri, Toshiyuki Miyata, Koji Habe, Hidekazu Tomimoto

Published in: Annals of Hematology | Issue 1/2019

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Excerpt

Dear Editor, …
Literature
1.
2.
Chu K, Wu SM, Stanley T, Stafford DW, High KA (1996) A mutation in the propeptide of factor IX leads to warfarin sensitivity by a novel mechanism. J Clin Invest 98(7):1619–1625CrossRefPubMedPubMedCentral
3.
Oldenburg J, Quenzel EM, Harbrecht U, Fregin A, Kress W, Muller CR, Hertfelder HJ, Schwaab R, Brackmann HH, Hanfland P (1997) Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy. Br J Haematol 98(1):240–244CrossRefPubMed
4.
Pezeshkpoor B, Czogalla KJ, Caspers M, Berkemeier AC, Liphardt K, Ghosh S, Kellner M, Ulrich S, Pavlova A, Oldenburg J (2018) Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations. Ann Hematol 97(6):1061–1069CrossRefPubMed
Metadata
Title
Major bleeding in a patient with warfarin-hypersensitive and factor IX propeptide variant, p.Ala37Thr, who was treated with a direct oral anti-Xa inhibitor
Authors
Asako Tamura
Hideo Wada
Makoto Ikejiri
Toshiyuki Miyata
Koji Habe
Hidekazu Tomimoto
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 1/2019
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-018-3398-2

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