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01-08-2018 | Original Article

Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma

Authors: Satoshi Yamasaki, Dai Chihara, Sung-Won Kim, Koji Izutsu, Kouji Iwato, Takahiro Fukuda, Naoyuki Uchida, Itsuto Amano, Hideyuki Nakazawa, Junya Kuroda, Hisako Hashimoto, Tatsuo Ichinohe, Yoshinobu Kanda, Yoshiko Atsuta, Junji Suzumiya, Ritsuro Suzuki

Published in: Annals of Hematology | Issue 8/2018

Abstract

Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014. The median overall survival (OS) rates were 48 and 65 months in the autologous and allogeneic HCT groups, respectively (P = 0.20). Significant risk factors for overall survival in R/R MCL patients after autologous HCT were > 60 years of age at HCT (P = 0.017), higher score of HCT-specific comorbidity index at HCT (P = 0.033), and receiving MCEC (ranimustine + carboplatin + etoposide + cyclophosphamide) regimen (P = 0.017), while higher performance status at HCT (P = 0.011) and longer interval from diagnosis to HCT (P = 0.0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT.

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Title: Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma
Authors: Satoshi Yamasaki
Dai Chihara
Sung-Won Kim
Koji Izutsu
Kouji Iwato
Takahiro Fukuda
Naoyuki Uchida
Itsuto Amano
Hideyuki Nakazawa
Junya Kuroda
Hisako Hashimoto
Tatsuo Ichinohe
Yoshinobu Kanda
Yoshiko Atsuta
Junji Suzumiya
Ritsuro Suzuki
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: Annals of Hematology / Issue 8/2018
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-018-3318-5

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