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Published in: Annals of Hematology 12/2017

01-12-2017 | Review Article

The progress and current status of immunotherapy in acute myeloid leukemia

Authors: Dan Yang, Xiuqun Zhang, Xuezhong Zhang, Yanli Xu

Published in: Annals of Hematology | Issue 12/2017

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Abstract

Recently, there has been remarkable progress in basic and preclinical studies of acute myeloid leukemia (AML). The improved outcomes of AML can largely be attributed to advances in supportive care and hematopoietic cell transplantation as opposed to conventional chemotherapy. However, as the 5-year survival rate remains low due to a high incidence of relapse, novel and effective treatments are urgently needed. Increasing attention is focusing on identifying suitable immunotherapeutic strategies for AML. Here, we describe the immunological features, mechanisms of immune escape, and recent progress in immunotherapy for AML. Problems encountered in the clinic will also be discussed. Although current outcomes may be limited, ongoing preclinical or clinical efforts are aimed at improving immunotherapy modalities and designing novel therapies, such as vaccines, monoclonal antibody therapy, chimeric antibody receptor-engineered T cells (CAR-T), TCR-engineered T cells (TCR-T), and checkpoint inhibitors, which may provide promising and effective therapies with higher specificity and efficacy for AML.
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Metadata
Title
The progress and current status of immunotherapy in acute myeloid leukemia
Authors
Dan Yang
Xiuqun Zhang
Xuezhong Zhang
Yanli Xu
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 12/2017
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-017-3148-x

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