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Published in:

01-04-2015 | Review Article

Epidemiology of chronic myeloid leukaemia: an update

Authors: Martin Höglund, Fredrik Sandin, Bengt Simonsson

Published in: Annals of Hematology | Special Issue 2/2015

Abstract

National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to those obtained from clinical trials. Reports from several European CML registries consistently show a crude annual incidence of 0.7–1.0/100,000, a median age at diagnosis of 57–60 years and a male/female ratio of 1.2–1.7. The incidence of CML has been stable over time. Worldwide, variations in the reported incidence of CML may be due to methodological issues, but a true difference between different geographical areas and/or ethnical subgroups cannot be excluded. The prevalence of CML is not well known but has been estimated to be 10–12/100,000 inhabitants with a steady increase due to the dramatic improvement in survival of these patients. In recent population-based studies, CML patients have an overall survival that is comparable to that shown in large clinical trials, though relative survival in patients >70 years is still decreased. The importance of socio-economic factors and health-care setting for outcome and the possible increased risk of secondary cancer in CML are areas of ongoing research.

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Title: Epidemiology of chronic myeloid leukaemia: an update
Authors: Martin Höglund
Fredrik Sandin
Bengt Simonsson
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Annals of Hematology / Issue Special Issue 2/2015
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-015-2314-2

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