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Annals of Hematology

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01-06-2014 | Letter to the Editor

MiR-125b regulates cell proliferation and survival in neonatal megakaryocytes

Authors: Ravinder Kandi, Rambabu Undi, Ravi Kumar Gutti

Published in: Annals of Hematology | Issue 6/2014

Excerpt

Dear Editor, …

Emmrich S, Henke K, Hegermann J, Ochs M, Reinhardt D, Klusmann JH (2012) miRNAs can increase the efficiency of ex vivo platelet generation. Ann Hematol 91(11):1673–1684PubMedCrossRef

Bousquet M, Nguyen D, Chen C, Shields L, Lodish HF (2012) MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA. Haematologica 97:1713–1721PubMedCentralPubMedCrossRef

Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D (2010) MiR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 24:478–490PubMedCentralPubMedCrossRef

Ferrer-Marin F, Liu ZJ, Gutti R, Sola-Visner M (2010) Neonatal thrombocytopenia and megakaryocytopoiesis. Semin Hematol 47:281–288PubMedCentralPubMedCrossRef

Liu ZJ, Italiano J Jr, Ferrer-Marin F, Gutti R, Bailey M, Poterjoy B, Rimsza L, Sola-Visner M (2011) Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood 117:4106–4117PubMedCentralPubMedCrossRef

Pastos KM, Slayton WB, Rimsza LM, Young L, Sola-Visner MC (2006) Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes. Blood 108:3360–3362PubMedCentralPubMedCrossRef

Sola MC, Du Y, Hutson AD, Christensen RD (2000) Dose–response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non-thrombocytopenic neonates to recombinant thrombopoietin. Br J Haematol 110:449–453PubMedCrossRef

Shaham L, Binder V, Gefen N, Borkhardt A, Izraeli S (2012) MiR-125 in normal and malignant hematopoiesis. Leukemia 26:2011–2018PubMedCrossRef

Title: MiR-125b regulates cell proliferation and survival in neonatal megakaryocytes
Authors: Ravinder Kandi
Rambabu Undi
Ravi Kumar Gutti
Publication date: 01-06-2014
Publisher: Springer Berlin Heidelberg
Published in: Annals of Hematology / Issue 6/2014
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-013-1928-5

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