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Annals of Hematology

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01-05-2007 | Original Article

Fusion of H4/D10S170 to PDGFRβ in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib

Authors: Matthias Drechsler, Barbara Hildebrandt, Andrea Kündgen, Ulrich Germing, Brigitte Royer-Pokora

Published in: Annals of Hematology | Issue 5/2007

Excerpt

Dear Editor, …

Cross NCP, Reiter A (2002) Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 16:1207–1212PubMedCrossRef

Schwaller J, Anastasiadou E, Cain D, Kutok J, Woyiski S, Willimas IR, LaStarza R, Crescendi B, Sternberg DW, Andreason P, Schiavo R, Siena S, Mecucci C, Gilliland GD (2001) H4(D10S170), a gene frequently rearranged in papillary thyroid carcinomas, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukaemia with t(5;10)(q33;q22). Blood 97:3910–3918PubMedCrossRef

Kulkarni S, Heath C, Parker S, Chase A, Iqbal A, Pocock F, Kaeda J, Cwynarski K, Goldman JM, Cross NCP (2000) Fusion of H4/D10S170 to the platelet-derived growth factor receptor β in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21). Cancer Res 60:3592–3598PubMed

Garcia JL, FontdeMora J, Hernandez JM, Queizan JA, Gutierrez NC, Hernandez JM San Miguel JF (2003) imatinib mesylat elicts positive clinical response in atypical chronic myeloid leukaemia involving the platelet-derived growth factor receptor beta. Blood 102:2699–2700PubMedCrossRef

Bastie J-N, Garcia I, Terré C, Cross NCP, Mahon F-X, Castaigne S (2004) Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor β-gene. Haematologica 89:1263–1264PubMed

Title: Fusion of H4/D10S170 to PDGFRβ in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib
Authors: Matthias Drechsler
Barbara Hildebrandt
Andrea Kündgen
Ulrich Germing
Brigitte Royer-Pokora
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: Annals of Hematology / Issue 5/2007
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-006-0247-5

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Fusion of H4/D10S170 to PDGFRβ in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib

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