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Annals of Hematology
Published in: Annals of Hematology 6/2004

01-06-2004 | Case Report

Rapid improvement of disseminated aspergillosis with caspofungin/voriconazole combination in an adult leukemic patient

Authors: G. Damaj, V. Ivanov, B. Le Brigand, E. D’incan, M. F. Doglio, K. Bilger, C. Faucher, N. Vey, J. A. Gastaut

Published in: Annals of Hematology | Issue 6/2004

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Abstract

A 57-year-old man with acute myeloid leukemia (AML) French-American-British (FAB) 4 developed disseminated invasive cerebral and pulmonary aspergillosis during postinduction aplasia. According to international consensus, infection was categorized as probable (two host factors: deep neutropenia for >10 days and refractory fever for >96 h; major clinical criteria of lower respiratory tract and CNS invasive fungal infection; positive results for galactomannan antigen in three blood samples). After the failure of standard amphotericin-based therapy, the spectacular regression of multifocal brain and lung lesions was rapidly achieved under a caspofungin acetate/voriconazole combination. Further permanent caspofungin maintenance with voriconazole added during aplasia periods permitted two consolidation courses and autograft-based intensification without any delay.
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Metadata
Title
Rapid improvement of disseminated aspergillosis with caspofungin/voriconazole combination in an adult leukemic patient
Authors
G. Damaj
V. Ivanov
B. Le Brigand
E. D’incan
M. F. Doglio
K. Bilger
C. Faucher
N. Vey
J. A. Gastaut
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 6/2004
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-003-0792-0

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