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01-02-2004 | Case Report

Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)

Authors: B. Alpen, T. Wündisch, J. Dierlamm, G. Börsch, M. Stolte, A. Neubauer

Published in: Annals of Hematology | Issue 2/2004

Abstract

To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.

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Title: Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)
Authors: B. Alpen
T. Wündisch
J. Dierlamm
G. Börsch
M. Stolte
A. Neubauer
Publication date: 01-02-2004
Publisher: Springer-Verlag
Published in: Annals of Hematology / Issue 2/2004
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-003-0763-5

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