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Annals of Hematology
Published in: Annals of Hematology 11/2003

01-11-2003 | Original Article

Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers

Authors: I. M. Bragós, N. I. Noguera, M. P. Raviola, A. C. Milani

Published in: Annals of Hematology | Issue 11/2003

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Abstract

Prevalence of alpha gene triplication or deletion in β-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -α3.7 allele presents a higher prevalence than αααanti3.7; thus, α-thalassemia associated with β-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).
Literature
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Flint J, Harding R, Boyce A, Clegg JB (1998) The population genetic of the haemoglobinopathies. In: Rodgers GP (ed) Sickle cell disease and thalassaemia. Baillieres Clin Haematol 11:53–89PubMed
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Noguera N, Bragós I, Milani A (2002) Prevalence of -α3,7 thalassemia in Argentina. Hemoglobin 26:103–106CrossRefPubMed
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Metadata
Title
Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers
Authors
I. M. Bragós
N. I. Noguera
M. P. Raviola
A. C. Milani
Publication date
01-11-2003
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 11/2003
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-003-0738-6

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