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Published in: CardioVascular and Interventional Radiology 7/2017

01-07-2017 | Clinical Investigation

Validation of the Risk Prediction Models STATE-Score and START-Strategy to Guide TACE Treatment in Patients with Hepatocellular Carcinoma

Authors: Aline Mähringer-Kunz, Roman Kloeckner, Michael B. Pitton, Christoph Düber, Irene Schmidtmann, Peter R. Galle, Sandra Koch, Arndt Weinmann

Published in: CardioVascular and Interventional Radiology | Issue 7/2017

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Abstract

Purpose

Several scoring systems that guide patients’ treatment regimen for transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) have been introduced, but none have gained widespread acceptance in clinical practice. The purpose of this study is to externally validate the Selection for TrAnsarterial chemoembolization TrEatment (STATE)-score and START-strategy [i.e., sequential use of the STATE-score and Assessment for Retreatment with TACE (ART)-score].

Materials and Methods

From January 2000 to September 2015, 933 patients with HCC underwent TACE at our institution. All variables needed to calculate the STATE-score and implement the START-strategy were determined. STATE comprised serum albumin, up-to-seven criteria, and C-reactive protein (CRP). ART comprised an increase in aspartate aminotransferase, the Child–Pugh score, and a radiological tumor response. Overall survival was calculated, and multivariate analysis performed. In addition, the STATE-score and START-strategy were validated using the Harrell’s C-index and integrated Brier score (IBS).

Results

The STATE-score was calculated in 228 patients. Low and high STATE-scores corresponded to median survival of 14.3 and 20.2 months, respectively. Harrell’s C was 0.558 and IBS 0.133. For the STATE-score, significant predictors of survival were up-to-seven criteria (p = 0.006) and albumin (p = 0.022). CRP values were not predictive (p = 0.367). The ART-score was calculated in 207 patients. Combining the STATE-score and ART-score led to a Harrell’s C of 0.580 and IBS of 0.132.

Conclusion

The STATE-score was unable to reliably determine the suitability for initial TACE. The START-strategy only slightly improved the predictive ability compared to the ART-score alone. Therefore, neither the STATE-score nor START-strategy alone provides sufficient certainty for clear-cut clinical decisions.
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Metadata
Title
Validation of the Risk Prediction Models STATE-Score and START-Strategy to Guide TACE Treatment in Patients with Hepatocellular Carcinoma
Authors
Aline Mähringer-Kunz
Roman Kloeckner
Michael B. Pitton
Christoph Düber
Irene Schmidtmann
Peter R. Galle
Sandra Koch
Arndt Weinmann
Publication date
01-07-2017
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 7/2017
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-017-1606-4

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