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CardioVascular and Interventional Radiology

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Open Access 01-02-2016 | Work In Progress

Functional Imaging of the Foot with Perfusion Angiography in Critical Limb Ischemia

Authors: Jim A. Reekers, Mark J. W. Koelemay, Henk A. Marquering, Ed T. van Bavel

Published in: CardioVascular and Interventional Radiology | Issue 2/2016

Abstract

Purpose

To report on the first clinical experience with perfusion angiography (PA) of the foot in patients with chronic critical limb ischemia.

Materials and Methods

PA is a post-processing software algorithm and no extra digital subtraction angiography (DSA) has to be performed for this analysis. The data used to test the feasibility of PA were obtained from a consecutive group of 89 patients with CLI who were treated with standard below the knee angioplasty and 12 separate patients who were not suitable for endovascular revascularization.

Results

Motion artifacts in the dataset of the DSA made post-procedural analysis impossible in 10 % intervention. In the majority of patients (59/68) PA showed an increase in volume flow in the foot after successful angioplasty of the crural vessels. However, in 9/68 patients no increase was seen after successful angioplasty. With the use of a local administered competitive α-adrenergic receptor antagonist, it is also possible to test and quantify the capillary resistance index which is a parameter for the remaining functionality of the microcirculation in CLI patients.

Conclusion

PA might be used as a new endpoint for lower limb revascularization and can also be used to test the functionality the microcirculation to identify sub-types of patients with CLI. Clinical evaluation and standardization of PA is mandatory before introduction in daily practice.

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Title: Functional Imaging of the Foot with Perfusion Angiography in Critical Limb Ischemia
Authors: Jim A. Reekers
Mark J. W. Koelemay
Henk A. Marquering
Ed T. van Bavel
Publication date: 01-02-2016
Publisher: Springer US
Published in: CardioVascular and Interventional Radiology / Issue 2/2016
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-015-1253-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Functional Imaging of the Foot with Perfusion Angiography in Critical Limb Ischemia

Abstract

Purpose

Materials and Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusion

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