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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 2/2011

01-04-2011 | Case Report

Spontaneous Regression of Multiple Pulmonary Metastases After Radiofrequency Ablation of a Single Metastasis

Authors: Pramod Rao, Bernard Escudier, Thierry de Baere

Published in: CardioVascular and Interventional Radiology | Issue 2/2011

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Abstract

We report two cases of spontaneous regression of multiple pulmonary metastases occurring after radiofrequency ablation (RFA) of a single lung metastasis. To the best of our knowledge, these are the first such cases reported. These two patients presented with lung metastases progressive despite treatment with interleukin-2, interferon, or sorafenib but were safely ablated with percutaneous RFA under computed tomography guidance. Percutaneous RFA allowed control of the targeted tumors for >1 year. Distant lung metastases presented an objective response despite the fact that they received no targeted local treatment. Local ablative techniques, such as RFA, induce the release of tumor-degradation product, which is probably responsible for an immunologic reaction that is able to produce a response in distant tumors.
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Metadata
Title
Spontaneous Regression of Multiple Pulmonary Metastases After Radiofrequency Ablation of a Single Metastasis
Authors
Pramod Rao
Bernard Escudier
Thierry de Baere
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
CardioVascular and Interventional Radiology / Issue 2/2011
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-010-9896-9

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