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01-12-2020 | Computed Tomography | Original Scientific Report

Diffusion-Weighted MRI Predicts Lymph Node Metastasis and Tumor Aggressiveness in Resectable Pancreatic Neuroendocrine Tumors

Authors: Norifumi Harimoto, Kenichiro Araki, Kouki Hoshino, Ryo Muranushi, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Hiroyasu Tomonaga, Tetsuya Higuchi, Yoshito Tsushima, Hayato Ikota, Ken Shirabe

Published in: World Journal of Surgery | Issue 12/2020

Abstract

Objectives

The aim of this study was to identify whether diffusion-weighted magnetic resonance imaging (DW-MRI) can predict the malignant behavior of preoperative well-differentiated pancreatic neuroendocrine tumors (PanNETs).

Method

Forty patients with PanNETs who underwent pancreatectomy were enrolled in this study. The apparent diffusion coefficient (ADC) values were measured. Clinicopathological factors were compared in patients with high ADC and low ADC values and in patients with and without lymph node metastasis (LNM).

Result

The low ADC group was significantly associated with higher Ki-67 index, higher mitotic count, larger tumor size, higher rate of LNM, and venous invasion. In patients with low ADC values, the incidence of LNMs was 33.3%. In patients with high ADC values, there were no patients with LNM being 0%. A significant negative correlation was found between the mean ADC values and the Ki-67 index and between the mean ADC values and the mitotic count. In multivariate analysis, neural invasion and mean ADC values ≤ 1458 were independent predictors of LNM.

Conclusion

ADC values obtained using DW-MRI in the preoperative assessment of patients with PanNETs might be a useful predictor of malignant potential, especially LNM.

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Title: Diffusion-Weighted MRI Predicts Lymph Node Metastasis and Tumor Aggressiveness in Resectable Pancreatic Neuroendocrine Tumors
Authors: Norifumi Harimoto
Kenichiro Araki
Kouki Hoshino
Ryo Muranushi
Kei Hagiwara
Norihiro Ishii
Mariko Tsukagoshi
Takamichi Igarashi
Akira Watanabe
Norio Kubo
Hiroyasu Tomonaga
Tetsuya Higuchi
Yoshito Tsushima
Hayato Ikota
Ken Shirabe
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Computed Tomography
Metastasis
Pancreatectomy
Computed Tomography
Neuroendocrine Tumor
Published in: World Journal of Surgery / Issue 12/2020
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-020-05736-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Diffusion-Weighted MRI Predicts Lymph Node Metastasis and Tumor Aggressiveness in Resectable Pancreatic Neuroendocrine Tumors

Abstract

Objectives

Method

Result

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Method

Result

Conclusion

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