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Published in: World Journal of Surgery 7/2020

01-07-2020 | Acute Abdomen | Surgery in Low and Middle Income Countries

District General Hospital Surgical Capacity and Mortality Trends in Patients with Acute Abdomen in Malawi

Authors: Laura N. Purcell, Brittany Robinson, Vanessa Msosa, Jared Gallaher, Anthony Charles

Published in: World Journal of Surgery | Issue 7/2020

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Abstract

Background

The burden of emergency general surgery conditions is high in sub-Saharan Africa, and poor access to surgical care leads to poor patient outcomes. We examined the trends in mortality in patients presenting with an acute abdomen to a referral hospital.

Methods

A retrospective analysis of the prospectively collected Kamuzu Central Hospital Acute Care Surgery database was performed (January 2014 to July 2019). Bivariate analysis was conducted by year of admission. A multivariate Poisson regression was performed to identify predictors of mortality.

Results

During the study, 2509 patients with acute abdomen presented. The majority of patients presenting were transferred from outside hospitals (n = 2097, 83.9%). Mortality was highest in patients with preoperative diagnosis of peritonitis (n = 119, 22.2%), bowel obstruction (n = 214, 18.7%), and volvuli (n = 51, 18.6%). There was no difference in mortality by year, p = 0.1. On multivariate Poisson regression, there was an increased relative risk of mortality with being transferred (RR 1.31, 95% CI 1.12–1.55, p = 0.002), as well as undergoing an operation within 1–2 days (RR 1.48, 95% CI 1.16–1.87, p < 0.001) and >2 days (RR 1.46, 95% CI 1.17–1.82, p = 0.001) after presentation.

Conclusion

The majority of patients in our study who presented with an acute abdomen were transferred from district hospitals, which resulted in high mortality due to delays in surgical care. Therefore, the WHO’s recommendation that the majority of district hospitals perform the Bellwether procedures does not occur in district hospitals in central Malawi. District hospitals require significant resource investment to reduce transfers needs and patient mortality.
Literature
1.
go back to reference Weiser TG, Regenbogen SE, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, Gawande AA (2008) An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet 372(9633):139–144CrossRef Weiser TG, Regenbogen SE, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, Gawande AA (2008) An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet 372(9633):139–144CrossRef
2.
go back to reference GlobalSurg Collaborative, Fitzgerald JE, Khatri C, Glasbey JC, Mohan R, Lilford R, Harrison EM, Holmer H, Hall N, Kim SH, Negida A (2016) Mortality of emergency abdominal surgery in high, middle and low income countries. Br J Surg 103(8):971–988CrossRef GlobalSurg Collaborative, Fitzgerald JE, Khatri C, Glasbey JC, Mohan R, Lilford R, Harrison EM, Holmer H, Hall N, Kim SH, Negida A (2016) Mortality of emergency abdominal surgery in high, middle and low income countries. Br J Surg 103(8):971–988CrossRef
4.
go back to reference Weiser TG, Uribe-Leitz T, Fu R, Jaramillo J, Maurer L, Esquivel MM, Gawande AA, Haynes AB (2015) Variability in mortality after caesarean delivery, appendectomy, and groin hernia repair in low-income and middle-income countries: implications for expanding surgical services. Lancet 27(385):S34CrossRef Weiser TG, Uribe-Leitz T, Fu R, Jaramillo J, Maurer L, Esquivel MM, Gawande AA, Haynes AB (2015) Variability in mortality after caesarean delivery, appendectomy, and groin hernia repair in low-income and middle-income countries: implications for expanding surgical services. Lancet 27(385):S34CrossRef
6.
go back to reference Thaddeus S, Maine D (1994) Too far to walk: maternal mortality in context. Soc Sci Med 38(8):1091–1110CrossRef Thaddeus S, Maine D (1994) Too far to walk: maternal mortality in context. Soc Sci Med 38(8):1091–1110CrossRef
7.
go back to reference Qureshi JS, Young S, Muyco AP, Borgstein E, Charles AG, Mulwafu W, Shores CG, Banza L, Cairns B, Viste A, Mkandawire N (2013) Addressing Malawi’s surgical workforce crisis: a sustainable paradigm for training and collaboration in Africa. Surgery 153(2):272–281CrossRef Qureshi JS, Young S, Muyco AP, Borgstein E, Charles AG, Mulwafu W, Shores CG, Banza L, Cairns B, Viste A, Mkandawire N (2013) Addressing Malawi’s surgical workforce crisis: a sustainable paradigm for training and collaboration in Africa. Surgery 153(2):272–281CrossRef
8.
go back to reference McIsaac DI, Abdulla K, Yang H, Sundaresan S, Doering P, Vaswani SG, Thavorn K, Forster AJ (2017) Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score-matched observational cohort study. CMAJ 189(27):E905–E912CrossRef McIsaac DI, Abdulla K, Yang H, Sundaresan S, Doering P, Vaswani SG, Thavorn K, Forster AJ (2017) Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score-matched observational cohort study. CMAJ 189(27):E905–E912CrossRef
9.
go back to reference O’Neill KM, Greenberg SL, Cherian M, Gillies RD, Daniels KM, Roy N, Raykar NP, Riesel JN, Spiegel D, Watters DA, Gruen RL (2016) Bellwether procedures for monitoring and planning essential surgical care in low-and middle-income countries: caesarean delivery, laparotomy, and treatment of open fractures. World J Surg 40(11):2611–2619. https://doi.org/10.1007/s00268-016-3614-y CrossRefPubMed O’Neill KM, Greenberg SL, Cherian M, Gillies RD, Daniels KM, Roy N, Raykar NP, Riesel JN, Spiegel D, Watters DA, Gruen RL (2016) Bellwether procedures for monitoring and planning essential surgical care in low-and middle-income countries: caesarean delivery, laparotomy, and treatment of open fractures. World J Surg 40(11):2611–2619. https://​doi.​org/​10.​1007/​s00268-016-3614-y CrossRefPubMed
10.
go back to reference Van Amelsfoort JJ, Van Leeuwen PA, Jiskoot P, Ratsma YE (2010) Surgery in Malawi—the training of clinical officers. Trop Doct 40(2):74–76CrossRef Van Amelsfoort JJ, Van Leeuwen PA, Jiskoot P, Ratsma YE (2010) Surgery in Malawi—the training of clinical officers. Trop Doct 40(2):74–76CrossRef
11.
go back to reference Buck DL, Vester-Andersen M, Møller MH (2013) Danish clinical register of emergency surgery. surgical delay is a critical determinant of survival in perforated peptic ulcer. Br J Surg 100(8):1045–1049CrossRef Buck DL, Vester-Andersen M, Møller MH (2013) Danish clinical register of emergency surgery. surgical delay is a critical determinant of survival in perforated peptic ulcer. Br J Surg 100(8):1045–1049CrossRef
12.
go back to reference Mozer AB, Spaniolas K, Sippey ME, Celio A, Manwaring ML, Kasten KR (2017) Post-operative morbidity, but not mortality, is worsened by operative delay in septic diverticulitis. Int J Colorectal Dis 32(2):193–199CrossRef Mozer AB, Spaniolas K, Sippey ME, Celio A, Manwaring ML, Kasten KR (2017) Post-operative morbidity, but not mortality, is worsened by operative delay in septic diverticulitis. Int J Colorectal Dis 32(2):193–199CrossRef
13.
go back to reference Ndayizeye L, Ngarambe C, Smart B, Riviello R, Majyambere JP, Rickard J (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160(6):1645–1656CrossRef Ndayizeye L, Ngarambe C, Smart B, Riviello R, Majyambere JP, Rickard J (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160(6):1645–1656CrossRef
14.
go back to reference Memon AA, Siddiqui FG, Abro AH, Agha AH, Lubna S, Memon AS (2012) An audit of secondary peritonitis at a tertiary care university hospital of Sindh, Pakistan. World J Emerg Surg 7(1):6CrossRef Memon AA, Siddiqui FG, Abro AH, Agha AH, Lubna S, Memon AS (2012) An audit of secondary peritonitis at a tertiary care university hospital of Sindh, Pakistan. World J Emerg Surg 7(1):6CrossRef
15.
go back to reference Kotiso B, Abdurahman Z (2007) Pattern of acute abdomen in adult patients in Tikur Anbessa Teaching Hospital, Addis Ababa, Ethiopia. East Cent Afr J Surg 12(1):47–52 Kotiso B, Abdurahman Z (2007) Pattern of acute abdomen in adult patients in Tikur Anbessa Teaching Hospital, Addis Ababa, Ethiopia. East Cent Afr J Surg 12(1):47–52
16.
go back to reference Diaz-Plasencia J, Sanchez C, Bardales M, Rebaza H, Calipuy W (1993) Operative mortality in sigmoid volvulus. Revista de gastroenterologia del Peru: organo oficial de la Sociedad de Gastroenterologia del Peru. 13(1):37–44 Diaz-Plasencia J, Sanchez C, Bardales M, Rebaza H, Calipuy W (1993) Operative mortality in sigmoid volvulus. Revista de gastroenterologia del Peru: organo oficial de la Sociedad de Gastroenterologia del Peru. 13(1):37–44
17.
go back to reference Chalya PL, Mabula JB (2015) Sigmoid volvulus and ileo-sigmoid knotting: a 5-year experience at a tertiary care hospital in Tanzania. World J Emerg Surg 10(1):10CrossRef Chalya PL, Mabula JB (2015) Sigmoid volvulus and ileo-sigmoid knotting: a 5-year experience at a tertiary care hospital in Tanzania. World J Emerg Surg 10(1):10CrossRef
18.
go back to reference Stewart B, Khanduri P, McCord C, Ohene-Yeboah M, Uranues S, Vega Rivera F, Mock C (2014) Global disease burden of conditions requiring emergency surgery. Br J Surg 101(1):e9–e22CrossRef Stewart B, Khanduri P, McCord C, Ohene-Yeboah M, Uranues S, Vega Rivera F, Mock C (2014) Global disease burden of conditions requiring emergency surgery. Br J Surg 101(1):e9–e22CrossRef
19.
go back to reference Meara JG, Leather AJ, Hagander L, Alkire BC, Alonso N, Ameh EA, Bickler SW, Conteh L, Dare AJ, Davies J, Mérisier ED (2015) Global surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386(9993):569–624CrossRef Meara JG, Leather AJ, Hagander L, Alkire BC, Alonso N, Ameh EA, Bickler SW, Conteh L, Dare AJ, Davies J, Mérisier ED (2015) Global surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386(9993):569–624CrossRef
20.
go back to reference Abdullah F, Choo S, Hesse AA, Abantanga F, Sory E, Osen H, Ng J, McCord CW, Cherian M, Fleischer-Djoleto C, Perry H (2011) Assessment of surgical and obstetrical care at 10 district hospitals in Ghana using on-site interviews. J Surg Res 171(2):461–466CrossRef Abdullah F, Choo S, Hesse AA, Abantanga F, Sory E, Osen H, Ng J, McCord CW, Cherian M, Fleischer-Djoleto C, Perry H (2011) Assessment of surgical and obstetrical care at 10 district hospitals in Ghana using on-site interviews. J Surg Res 171(2):461–466CrossRef
21.
go back to reference Kingham TP, Kamara TB, Cherian MN, Gosselin RA, Simkins M, Meissner C, Foray-Rahall L, Daoh KS, Kabia SA, Kushner AL (2009) Quantifying surgical capacity in Sierra Leone: a guide for improving surgical care. Arch Surg 144(2):122–127CrossRef Kingham TP, Kamara TB, Cherian MN, Gosselin RA, Simkins M, Meissner C, Foray-Rahall L, Daoh KS, Kabia SA, Kushner AL (2009) Quantifying surgical capacity in Sierra Leone: a guide for improving surgical care. Arch Surg 144(2):122–127CrossRef
22.
go back to reference Taira BR, Cherian MN, Yakandawala H, Kesavan R, Samarage SM, DeSilva M (2010) Survey of emergency and surgical capacity in the conflict-affected regions of Sri Lanka. World J Surg 34(3):428–432CrossRef Taira BR, Cherian MN, Yakandawala H, Kesavan R, Samarage SM, DeSilva M (2010) Survey of emergency and surgical capacity in the conflict-affected regions of Sri Lanka. World J Surg 34(3):428–432CrossRef
23.
go back to reference Lavy C, Tindall A, Steinlechner C, Mkandawire N, Chimangeni S (2007) Surgery in Malawi—a national survey of activity in rural and urban hospitals. Ann R Coll Surg Engl 89(7):722–724CrossRef Lavy C, Tindall A, Steinlechner C, Mkandawire N, Chimangeni S (2007) Surgery in Malawi—a national survey of activity in rural and urban hospitals. Ann R Coll Surg Engl 89(7):722–724CrossRef
26.
go back to reference Adam T, Murray CJ (2003) Making choices in health: WHO guide to cost-effectiveness analysis. World Health Organization, Geneva Adam T, Murray CJ (2003) Making choices in health: WHO guide to cost-effectiveness analysis. World Health Organization, Geneva
29.
go back to reference Mock CN, Jurkovich GJ, Arreola-Risa C, Maier RV (1998) Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development. J Trauma Acute Care Surg 44(5):804–814CrossRef Mock CN, Jurkovich GJ, Arreola-Risa C, Maier RV (1998) Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development. J Trauma Acute Care Surg 44(5):804–814CrossRef
30.
go back to reference Henry JA, Reingold AL (2012) Prehospital trauma systems reduce mortality in developing countries: a systematic review and meta-analysis. J Trauma Acute Care Surg 73(1):261–268CrossRef Henry JA, Reingold AL (2012) Prehospital trauma systems reduce mortality in developing countries: a systematic review and meta-analysis. J Trauma Acute Care Surg 73(1):261–268CrossRef
31.
go back to reference Diaz JJ Jr, Norris PR, Gunter OL, Collier BR, Riordan WP, Morris JA Jr (2011) Does regionalization of acute care surgery decrease mortality? J Trauma Acute Care Surg 71(2):442–446CrossRef Diaz JJ Jr, Norris PR, Gunter OL, Collier BR, Riordan WP, Morris JA Jr (2011) Does regionalization of acute care surgery decrease mortality? J Trauma Acute Care Surg 71(2):442–446CrossRef
32.
go back to reference Maine RG, Kajombo C, Purcell L, Gallaher JR, Reid TD, Charles AG (2019) Effect of in-hospital delays on surgical mortality for emergency general surgery conditions at a tertiary hospital in Malawi. BJS Open 3(3):367–375CrossRef Maine RG, Kajombo C, Purcell L, Gallaher JR, Reid TD, Charles AG (2019) Effect of in-hospital delays on surgical mortality for emergency general surgery conditions at a tertiary hospital in Malawi. BJS Open 3(3):367–375CrossRef
33.
go back to reference Adamu A, Maigatari M, Lawal K, Iliyasu M (2010) Waiting time for emergency abdominal surgery in Zaria, Nigeria. Afric Health Sci 10(1):46 Adamu A, Maigatari M, Lawal K, Iliyasu M (2010) Waiting time for emergency abdominal surgery in Zaria, Nigeria. Afric Health Sci 10(1):46
34.
go back to reference Gona SK, Alassan MK, Marcellin KG, Henriette KY, Adama C, Toussaint A, Manuela EA, Sylvain SG, Anthony AA, Francis ES (2016) Postoperative morbidity and mortality of perforated peptic ulcer: retrospective cohort study of risk factors among Black Africans in Côte d’Ivoire. Gastroenterol Res Pract. https://doi.org/10.1155/2016/2640730 Gona SK, Alassan MK, Marcellin KG, Henriette KY, Adama C, Toussaint A, Manuela EA, Sylvain SG, Anthony AA, Francis ES (2016) Postoperative morbidity and mortality of perforated peptic ulcer: retrospective cohort study of risk factors among Black Africans in Côte d’Ivoire. Gastroenterol Res Pract. https://​doi.​org/​10.​1155/​2016/​2640730
35.
go back to reference Chadbunchachai W, Saranrittichai S, Sriwiwat S, Chumsri J, Kulleab S, Jaikwang P (2003) Study on performance following key performance indicators for trauma care: Khon Kaen Hospital 2000. J Med Assoc Thailand 86(1):1–7 Chadbunchachai W, Saranrittichai S, Sriwiwat S, Chumsri J, Kulleab S, Jaikwang P (2003) Study on performance following key performance indicators for trauma care: Khon Kaen Hospital 2000. J Med Assoc Thailand 86(1):1–7
Metadata
Title
District General Hospital Surgical Capacity and Mortality Trends in Patients with Acute Abdomen in Malawi
Authors
Laura N. Purcell
Brittany Robinson
Vanessa Msosa
Jared Gallaher
Anthony Charles
Publication date
01-07-2020
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 7/2020
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-020-05468-4

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