Skip to main content
Top
Published in: World Journal of Surgery 10/2018

01-10-2018 | Original Scientific Report

Critical Care Management of Peritonitis in a Low-Resource Setting

Authors: Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere

Published in: World Journal of Surgery | Issue 10/2018

Login to get access

Abstract

Background

Management of critically ill patients is challenging in a low-resource setting. In Rwanda, peritonitis is a common surgical condition where patients often present late, with advanced disease. We aim to describe critical care management of patients with peritonitis in Rwanda.

Methods

Data were collected at a tertiary referral hospital in Rwanda on patients undergoing operation for peritonitis over a 6-month period. Data included epidemiology, hospital course and outcomes. Patients requiring admission to the intensive care unit (ICU) were compared with those not requiring ICU admission using Chi-square and Wilcoxon rank-sum test.

Results

Over a 6-month period, 280 patients were operated for peritonitis. Of these, 46 (16.4%) were admitted to the ICU. The most common diagnoses were intestinal obstruction (N = 17, 37.0%) and typhoid intestinal perforation (N = 6, 13.0%). Thirty-nine (89%) patients had sepsis. The median American Society of Anesthesiologist score was 3 (range 2–4), and the median Surgical Apgar Score was 4 (range 0–6). Twenty-four (52.2%) patients required vasopressors, with dopamine and adrenaline being the only vasopressors available. Patients admitted to the ICU, compared with non-critically ill patients, were more likely to have major complications (80.4 vs. 14%, p < 0.001), unplanned reoperation (28 vs. 10%, p < 0.001) and death (72 vs. 8%, p < 0.001).

Conclusion

Patients with peritonitis admitted to the ICU commonly presented with features of sepsis. Due to limited resources in this setting, interventions are primarily supportive with intravenous fluids, intravenous antibiotics, ventilator support and vasopressors. Morbidity and mortality remain high in this patient population.
Literature
1.
go back to reference Meara JG, Leather AJ, Hagander L et al (2015) Global Surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386:569–624CrossRefPubMed Meara JG, Leather AJ, Hagander L et al (2015) Global Surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386:569–624CrossRefPubMed
2.
go back to reference Vukoja M, Riviello E, Gavrilovic S et al (2014) A survey on critical care resources and practices in low- and middle-income countries. Glob Heart 9(337–342):e331–e335 Vukoja M, Riviello E, Gavrilovic S et al (2014) A survey on critical care resources and practices in low- and middle-income countries. Glob Heart 9(337–342):e331–e335
3.
go back to reference Firth P, Ttendo S (2012) Intensive care in low-income countries–a critical need. N Engl J Med 367:1974–1976CrossRefPubMed Firth P, Ttendo S (2012) Intensive care in low-income countries–a critical need. N Engl J Med 367:1974–1976CrossRefPubMed
4.
go back to reference Stafford RE, Morrison CA, Godfrey G et al (2014) Challenges to the provision of emergency services and critical care in resource-constrained settings. Glob Heart 9:319–323CrossRefPubMed Stafford RE, Morrison CA, Godfrey G et al (2014) Challenges to the provision of emergency services and critical care in resource-constrained settings. Glob Heart 9:319–323CrossRefPubMed
5.
go back to reference Ilori IU, Kalu QN (2012) Intensive care admissions and outcome at the University of Calabar Teaching Hospital, Nigeria. J Crit Care 27(105):e101–e104 Ilori IU, Kalu QN (2012) Intensive care admissions and outcome at the University of Calabar Teaching Hospital, Nigeria. J Crit Care 27(105):e101–e104
6.
go back to reference Sawe HR, Mfinanga JA, Lidenge SJ et al (2014) Disease patterns and clinical outcomes of patients admitted in intensive care units of tertiary referral hospitals of Tanzania. BMC Int Health Hum Rights 14:26CrossRefPubMedPubMedCentral Sawe HR, Mfinanga JA, Lidenge SJ et al (2014) Disease patterns and clinical outcomes of patients admitted in intensive care units of tertiary referral hospitals of Tanzania. BMC Int Health Hum Rights 14:26CrossRefPubMedPubMedCentral
7.
go back to reference Schultz MJ, Dunser MW, Dondorp AM et al (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med 43:612–624CrossRefPubMed Schultz MJ, Dunser MW, Dondorp AM et al (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med 43:612–624CrossRefPubMed
8.
go back to reference Shrestha GS, Kwizera A, Lundeg G et al (2017) International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries. Lancet Infect Dis 17:893–895CrossRefPubMed Shrestha GS, Kwizera A, Lundeg G et al (2017) International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries. Lancet Infect Dis 17:893–895CrossRefPubMed
9.
go back to reference Tomlinson J, Haac B, Kadyaudzu C et al (2013) The burden of surgical diseases on critical care services at a tertiary hospital in sub-Saharan Africa. Trop Dr 43:27–29 Tomlinson J, Haac B, Kadyaudzu C et al (2013) The burden of surgical diseases on critical care services at a tertiary hospital in sub-Saharan Africa. Trop Dr 43:27–29
10.
go back to reference Riviello ED, Kiviri W, Fowler RA et al (2016) Predicting mortality in low-income country ICUs: the Rwanda Mortality Probability Model (R-MPM). PLoS ONE 11:e0155858CrossRefPubMedPubMedCentral Riviello ED, Kiviri W, Fowler RA et al (2016) Predicting mortality in low-income country ICUs: the Rwanda Mortality Probability Model (R-MPM). PLoS ONE 11:e0155858CrossRefPubMedPubMedCentral
11.
go back to reference Smith ZA, Ayele Y, McDonald P (2013) Outcomes in critical care delivery at Jimma University Specialised Hospital, Ethiopia. Anaesth Intensive Care 41:363–368PubMed Smith ZA, Ayele Y, McDonald P (2013) Outcomes in critical care delivery at Jimma University Specialised Hospital, Ethiopia. Anaesth Intensive Care 41:363–368PubMed
12.
go back to reference Andrews B, Muchemwa L, Kelly P et al (2014) Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med 42:2315–2324CrossRefPubMedPubMedCentral Andrews B, Muchemwa L, Kelly P et al (2014) Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med 42:2315–2324CrossRefPubMedPubMedCentral
13.
go back to reference Baelani I, Jochberger S, Laimer T et al (2011) Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers. Crit Care 15:R10CrossRefPubMedPubMedCentral Baelani I, Jochberger S, Laimer T et al (2011) Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers. Crit Care 15:R10CrossRefPubMedPubMedCentral
14.
go back to reference Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495CrossRefPubMed Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495CrossRefPubMed
15.
go back to reference Andrews B, Semler MW, Muchemwa L et al (2017) Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial. JAMA 318:1233–1240CrossRefPubMedPubMedCentral Andrews B, Semler MW, Muchemwa L et al (2017) Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial. JAMA 318:1233–1240CrossRefPubMedPubMedCentral
16.
go back to reference Ndayizeye L, Ngarambe C, Smart B et al (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160:1645–1656CrossRefPubMed Ndayizeye L, Ngarambe C, Smart B et al (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160:1645–1656CrossRefPubMed
18.
go back to reference WHO (2017) WHO model list of essential medicines. WHO, Geneva WHO (2017) WHO model list of essential medicines. WHO, Geneva
19.
go back to reference WHO (2017) The selection and use of essential medicine, executive summary. WHO, Geneva WHO (2017) The selection and use of essential medicine, executive summary. WHO, Geneva
20.
go back to reference Petroze RT, Nzayisenga A, Rusanganwa V et al (2012) Comprehensive national analysis of emergency and essential surgical capacity in Rwanda. Br J Surg 99:436–443CrossRefPubMed Petroze RT, Nzayisenga A, Rusanganwa V et al (2012) Comprehensive national analysis of emergency and essential surgical capacity in Rwanda. Br J Surg 99:436–443CrossRefPubMed
21.
go back to reference Barr J, Fraser GL, Puntillo K et al (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. Am J Health Syst Pharm 70:53–58PubMed Barr J, Fraser GL, Puntillo K et al (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. Am J Health Syst Pharm 70:53–58PubMed
22.
go back to reference Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377CrossRefPubMed Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377CrossRefPubMed
23.
go back to reference Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228CrossRefPubMed Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228CrossRefPubMed
Metadata
Title
Critical Care Management of Peritonitis in a Low-Resource Setting
Authors
Jennifer Rickard
Christian Ngarambe
Leonard Ndayizeye
Blair Smart
Robert Riviello
Jean Paul Majyambere
Publication date
01-10-2018
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 10/2018
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-018-4598-6

Other articles of this Issue 10/2018

World Journal of Surgery 10/2018 Go to the issue