Skip to main content
Top
Published in: World Journal of Surgery 12/2016

01-12-2016 | Original Scientific Report with Video

Robotic Enucleation for Benign or Borderline Tumours of the Pancreas: A Retrospective Analysis and Comparison from a High-Volume Centre in Asia

Authors: Jia-Bin Jin, Kai Qin, Hua Li, Zhi-Chong Wu, Qian Zhan, Xia-Xing Deng, Hao Chen, Bai-Yong Shen, Cheng-hong Peng, Hong-Wei Li

Published in: World Journal of Surgery | Issue 12/2016

Login to get access

Abstract

Background

Enucleation is increasingly performed for benign or borderline tumours of the pancreas because it is a parenchyma-sparing and less invasive procedure compared to conventional pancreatectomy, which reduces the risk of exocrine and endocrine insufficiency. This study retrospectively evaluated and compared the pre-, intra-, and post-operative clinical characteristics after open and robotic approaches for pancreatic enucleation.

Methods

Fifty-six cases of enucleation for benign or borderline tumours of the pancreas treated from March 2010 to July 2015 were identified by a retrospective search. These included 25 patients who underwent an open approach and 31 patients who underwent a robotic approach. The clinical characteristics were extracted and compared.

Results

The two groups had a similar location and pathology of the tumour. The robotic group had a significantly shorter operation time and significantly less blood loss than the open group. The rates of clinical pancreatic fistula (PF) formation and major complications were similar. The robotic approach could be applied for a tumour on the right side of the pancreas without increasing the incidence of clinical PF or other major complications. The patients with clinical PF had a significantly shorter distance between the lesion and the main pancreatic duct (MPD).

Conclusion

Robotic enucleation appears to be a feasible and safe approach for benign or borderline tumours of the pancreas and was associated with similarly favourable surgical outcomes as the open approach. Identifying and avoiding the MPD is an important step during enucleation.
Appendix
Available only for authorised users
Literature
1.
go back to reference Hüttner FJ, Koessler-Ebs J, Hackert T, Ulrich A, Büchler MW, Diener MK (2015) Meta-analysis of surgical outcome after enucleation versus standard resection for pancreatic neoplasms. Br J Surg 102(9):1026–1036CrossRefPubMed Hüttner FJ, Koessler-Ebs J, Hackert T, Ulrich A, Büchler MW, Diener MK (2015) Meta-analysis of surgical outcome after enucleation versus standard resection for pancreatic neoplasms. Br J Surg 102(9):1026–1036CrossRefPubMed
2.
go back to reference Cauley CE, Pitt HA, Ziegler KM, Nakeeb A, Schmidt CM, Zyromski NJ, House MG, Lillemoe KD (2012) Pancreatic enucleation: improved outcomes compared to resection. J Gastrointest Surg 16(7):1347–1353CrossRefPubMed Cauley CE, Pitt HA, Ziegler KM, Nakeeb A, Schmidt CM, Zyromski NJ, House MG, Lillemoe KD (2012) Pancreatic enucleation: improved outcomes compared to resection. J Gastrointest Surg 16(7):1347–1353CrossRefPubMed
3.
go back to reference Hackert T, Hinz U, Fritz S, Strobel O, Schneider L, Hartwig W, Buchler MW, Werner J (2011) Enucleation in pancreatic surgery: indications, technique, and outcome compared to standard pancreatic resections. Langenbecks Arch Surg 396(8):1197–1203CrossRefPubMed Hackert T, Hinz U, Fritz S, Strobel O, Schneider L, Hartwig W, Buchler MW, Werner J (2011) Enucleation in pancreatic surgery: indications, technique, and outcome compared to standard pancreatic resections. Langenbecks Arch Surg 396(8):1197–1203CrossRefPubMed
4.
go back to reference Zhang T, Xu J, Wang T, Liao Q, Dai M, Zhao Y (2013) Enucleation of pancreatic lesions: indications, outcomes, and risk factors for clinical pancreatic fistula. J Gastrointest Surg 17(12):2099–2104CrossRefPubMed Zhang T, Xu J, Wang T, Liao Q, Dai M, Zhao Y (2013) Enucleation of pancreatic lesions: indications, outcomes, and risk factors for clinical pancreatic fistula. J Gastrointest Surg 17(12):2099–2104CrossRefPubMed
5.
go back to reference Heeger K, Falconi M, Partelli S, Waldmann J, Crippa S, Fendrich V, Bartsch DK (2014) Increased rate of clinically relevant pancreatic fistula after deep enucleation of small pancreatic tumors. Langenbecks Arch Surg 399(3):315–321CrossRefPubMed Heeger K, Falconi M, Partelli S, Waldmann J, Crippa S, Fendrich V, Bartsch DK (2014) Increased rate of clinically relevant pancreatic fistula after deep enucleation of small pancreatic tumors. Langenbecks Arch Surg 399(3):315–321CrossRefPubMed
6.
go back to reference Song KB, Kim SC, Hwang DW, Lee JH, Lee DJ, Lee JW, Jun ES, Sin SH, Kim HE, Park KM, Lee YJ (2015) Enucleation for benign or low-grade malignant lesions of the pancreas: single-center experience with 65 consecutive patients. Surgery 158(5):1203–1210CrossRefPubMed Song KB, Kim SC, Hwang DW, Lee JH, Lee DJ, Lee JW, Jun ES, Sin SH, Kim HE, Park KM, Lee YJ (2015) Enucleation for benign or low-grade malignant lesions of the pancreas: single-center experience with 65 consecutive patients. Surgery 158(5):1203–1210CrossRefPubMed
7.
go back to reference Strobel O, Cherrez A, Hinz U, Mayer P, Kaiser J, Fritz S, Schneider L, Klauss M, Buchler MW, Hackert T (2015) Risk of pancreatic fistula after enucleation of pancreatic tumours. Br J Surg 102(10):1258–1266CrossRefPubMed Strobel O, Cherrez A, Hinz U, Mayer P, Kaiser J, Fritz S, Schneider L, Klauss M, Buchler MW, Hackert T (2015) Risk of pancreatic fistula after enucleation of pancreatic tumours. Br J Surg 102(10):1258–1266CrossRefPubMed
8.
go back to reference Costi R, Randone B, Mal F, Basato S, Levard H, Gayet B (2013) A critical appraisal of laparoscopic pancreatic enucleations: right-sided procedures (Pancreatic Head, Uncus) are not mini-invasive surgery. Surg Laparosc Endosc Percutan Tech 23(6):524–531CrossRefPubMed Costi R, Randone B, Mal F, Basato S, Levard H, Gayet B (2013) A critical appraisal of laparoscopic pancreatic enucleations: right-sided procedures (Pancreatic Head, Uncus) are not mini-invasive surgery. Surg Laparosc Endosc Percutan Tech 23(6):524–531CrossRefPubMed
9.
go back to reference Wang K, Wu W, Cong L, Xing X, Zhao Y (2014) Laparoscopic enucleation of insulinoma in a patient with annular pancreas: a rare case. J Gastrointest Surg 18(4):878–879CrossRefPubMed Wang K, Wu W, Cong L, Xing X, Zhao Y (2014) Laparoscopic enucleation of insulinoma in a patient with annular pancreas: a rare case. J Gastrointest Surg 18(4):878–879CrossRefPubMed
10.
go back to reference Zureikat AH, Moser AJ, Boone BA, Bartlett DL, Zenati M, Zeh HJ 3rd (2013) 250 robotic pancreatic resections: safety and feasibility. Ann Surg 258(4):554–559 discussion 559–562 PubMedPubMedCentral Zureikat AH, Moser AJ, Boone BA, Bartlett DL, Zenati M, Zeh HJ 3rd (2013) 250 robotic pancreatic resections: safety and feasibility. Ann Surg 258(4):554–559 discussion 559–562 PubMedPubMedCentral
11.
go back to reference Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138(1):8–13CrossRefPubMed Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138(1):8–13CrossRefPubMed
12.
go back to reference Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral
13.
go back to reference Cherif R, Gaujoux S, Sauvanet A (2012) Enucleation of pancreatic lesions through laparotomy. J Visc Surg 149(6):395–399CrossRefPubMed Cherif R, Gaujoux S, Sauvanet A (2012) Enucleation of pancreatic lesions through laparotomy. J Visc Surg 149(6):395–399CrossRefPubMed
14.
go back to reference Compton CC, Byrd DR, Garcia-Aguilar J, et al (2012) Exocrine and endocrine pancreas. In: AJCC cancer staging atlas, pp 297–308 Compton CC, Byrd DR, Garcia-Aguilar J, et al (2012) Exocrine and endocrine pancreas. In: AJCC cancer staging atlas, pp 297–308
16.
go back to reference Iacono C, Ruzzenente A, Bortolasi L, Guglielmi A (2014) Central pancreatectomy: the Dagradi Serio Iacono operation. Evolution of a surgical technique from the pioneers to the robotic approach. World J Gastroenterol 20(42):15674–15681CrossRefPubMedPubMedCentral Iacono C, Ruzzenente A, Bortolasi L, Guglielmi A (2014) Central pancreatectomy: the Dagradi Serio Iacono operation. Evolution of a surgical technique from the pioneers to the robotic approach. World J Gastroenterol 20(42):15674–15681CrossRefPubMedPubMedCentral
17.
go back to reference Stevanovic D, Stojanovic D, Mitrovic N, Jasarovic D, Milenkovic S, Bokun-Vukasinovic Z, Radovanovic D (2015) The laparoscopic enucleation for branch duct type intraductal papillary mucinous neoplasms located at the body of pancreas: a case report. Srp Arh Celok Lek 143(5–6):332–336CrossRefPubMed Stevanovic D, Stojanovic D, Mitrovic N, Jasarovic D, Milenkovic S, Bokun-Vukasinovic Z, Radovanovic D (2015) The laparoscopic enucleation for branch duct type intraductal papillary mucinous neoplasms located at the body of pancreas: a case report. Srp Arh Celok Lek 143(5–6):332–336CrossRefPubMed
18.
19.
go back to reference Del Chiaro M, Verbeke C, Salvia R, Kloppel G, Werner J, McKay C, Friess H, Manfredi R, Van Cutsem E, Lohr M, Segersvard R (2013) European experts consensus statement on cystic tumours of the pancreas. Dig Liver Dis 45(9):703–711CrossRefPubMed Del Chiaro M, Verbeke C, Salvia R, Kloppel G, Werner J, McKay C, Friess H, Manfredi R, Van Cutsem E, Lohr M, Segersvard R (2013) European experts consensus statement on cystic tumours of the pancreas. Dig Liver Dis 45(9):703–711CrossRefPubMed
20.
go back to reference Tanaka M, Fernandez-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12(3):183–197CrossRefPubMed Tanaka M, Fernandez-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12(3):183–197CrossRefPubMed
22.
go back to reference Mauriello C, Napolitano S, Gambardella C, Candela G, De Vita F, Orditura M, Sciascia V, Tartaglia E, Lanza M, Santini L, Conzo G (2015) Conservative management and parenchyma-sparing resections of pancreatic neuroendocrine tumors: literature review. Int J Surg 21:S10–S14CrossRefPubMed Mauriello C, Napolitano S, Gambardella C, Candela G, De Vita F, Orditura M, Sciascia V, Tartaglia E, Lanza M, Santini L, Conzo G (2015) Conservative management and parenchyma-sparing resections of pancreatic neuroendocrine tumors: literature review. Int J Surg 21:S10–S14CrossRefPubMed
23.
go back to reference Kulke MH, Shah MH, Benson AB 3rd, Bergsland E, Berlin JD, Blaszkowsky LS, Emerson L, Engstrom PF, Fanta P, Giordano T, Goldner WS, Halfdanarson TR, Heslin MJ, Kandeel F, Kunz PL, Kuvshinoff BW 2nd, Lieu C, Moley JF, Munene G, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Vauthey JN, Wolfgang C, Yao JC, Burns J, Freedman-Cass D (2015) Neuroendocrine tumors, version 1.2015. J Natl Compr Canc Netw 13(1):78–108PubMed Kulke MH, Shah MH, Benson AB 3rd, Bergsland E, Berlin JD, Blaszkowsky LS, Emerson L, Engstrom PF, Fanta P, Giordano T, Goldner WS, Halfdanarson TR, Heslin MJ, Kandeel F, Kunz PL, Kuvshinoff BW 2nd, Lieu C, Moley JF, Munene G, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Vauthey JN, Wolfgang C, Yao JC, Burns J, Freedman-Cass D (2015) Neuroendocrine tumors, version 1.2015. J Natl Compr Canc Netw 13(1):78–108PubMed
24.
go back to reference Ferrone CR, Tang LH, Tomlinson J, Gonen M, Hochwald SN, Brennan MF, Klimstra DS, Allen PJ (2007) Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified? J Clin Oncol 25(35):5609–5615CrossRefPubMed Ferrone CR, Tang LH, Tomlinson J, Gonen M, Hochwald SN, Brennan MF, Klimstra DS, Allen PJ (2007) Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified? J Clin Oncol 25(35):5609–5615CrossRefPubMed
25.
go back to reference Parekh JR, Wang SC, Bergsland EK, Venook AP, Warren RS, Kim GE, Nakakura EK (2012) Lymph node sampling rates and predictors of nodal metastasis in pancreatic neuroendocrine tumor resections: the UCSF experience with 149 patients. Pancreas 41(6):840–844CrossRefPubMed Parekh JR, Wang SC, Bergsland EK, Venook AP, Warren RS, Kim GE, Nakakura EK (2012) Lymph node sampling rates and predictors of nodal metastasis in pancreatic neuroendocrine tumor resections: the UCSF experience with 149 patients. Pancreas 41(6):840–844CrossRefPubMed
26.
go back to reference Chen S, Chen JZ, Zhan Q, Deng XX, Shen BY, Peng CH, Li HW (2015) Robot-assisted laparoscopic versus open pancreaticoduodenectomy: a prospective, matched, mid-term follow-up study. Surg Endosc 29(12):3698–3711CrossRefPubMed Chen S, Chen JZ, Zhan Q, Deng XX, Shen BY, Peng CH, Li HW (2015) Robot-assisted laparoscopic versus open pancreaticoduodenectomy: a prospective, matched, mid-term follow-up study. Surg Endosc 29(12):3698–3711CrossRefPubMed
27.
go back to reference Faitot F, Gaujoux S, Barbier L, Novaes M, Dokmak S, Aussilhou B, Couvelard A, Rebours V, Ruszniewski P, Belghiti J, Sauvanet A (2015) Reappraisal of pancreatic enucleations: a single-center experience of 126 procedures. Surgery 158(1):201–210CrossRefPubMed Faitot F, Gaujoux S, Barbier L, Novaes M, Dokmak S, Aussilhou B, Couvelard A, Rebours V, Ruszniewski P, Belghiti J, Sauvanet A (2015) Reappraisal of pancreatic enucleations: a single-center experience of 126 procedures. Surgery 158(1):201–210CrossRefPubMed
Metadata
Title
Robotic Enucleation for Benign or Borderline Tumours of the Pancreas: A Retrospective Analysis and Comparison from a High-Volume Centre in Asia
Authors
Jia-Bin Jin
Kai Qin
Hua Li
Zhi-Chong Wu
Qian Zhan
Xia-Xing Deng
Hao Chen
Bai-Yong Shen
Cheng-hong Peng
Hong-Wei Li
Publication date
01-12-2016
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 12/2016
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-016-3655-2

Other articles of this Issue 12/2016

World Journal of Surgery 12/2016 Go to the issue