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Published in: World Journal of Surgery 5/2011

01-05-2011

Surgical Experience of 204 Cases of Adult Choledochal Cyst Disease over 14 Years

Authors: Min-Jeong Cho, Shin Hwang, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Sung-Koo Lee, Myung-Hwan Kim, Sang-Soo Lee, Do-Hyun Park, Sung-Gyu Lee

Published in: World Journal of Surgery | Issue 5/2011

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Abstract

Background

This study presents our 14-year surgical experience with adult choledochal cyst disease (CCD), focusing on the clinical outcomes after surgical treatment.

Methods

Medical records of 204 adult patients who had undergone surgery for CCD were reviewed retrospectively.

Results

Median patient age was 40.2 years, and 157 (77%) of the patients were female. Todani classification was type I in 116 patients (56.9%), type II in 1 patient (0.5%), type IVa in 86 patients (42.2%), and type V in 1 patient (0.5%). Extrahepatic cyst excision and hepaticojejunostomy were performed in 185 patients (90.7%). Major perioperative complications occurred in 5 patients (2.5%), resulting in no mortality. Late complications occurred in 48 patients (23.6%). Concurrent cancer was diagnosed in 20 patients (9.8%). Mean age of patients with or without biliary cancer was 48.1 ± 13.2 years and 39.1 ± 11.8 years, respectively (P = 0.001). Anomalous union of the pancreaticobiliary duct was more frequently associated with gallbladder cancer than with bile duct cancer. De novo malignancy at the cyst remnant occurred in 2 patients (1%). The survival outcomes in CCD patients with concurrent biliary cancer were comparable to those in cancer patients without CCD.

Conclusions

As a result of diverse features of adult CCD, various clinical problems occurred after surgical excision. Surgical treatment for adult patients with CCDs having complex features should be individualized to maintain a balance between risk of surgery and potential risk of late complications.
Literature
1.
go back to reference Todani T, Watanabe Y, Narusue M et al (1997) Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg 134:263–269CrossRef Todani T, Watanabe Y, Narusue M et al (1997) Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg 134:263–269CrossRef
2.
go back to reference Yamaguchi M (1980) Congenital choledochal cyst: analysis of 1,433 patients in the Japanese literature. Am J Surg 140:653–657PubMedCrossRef Yamaguchi M (1980) Congenital choledochal cyst: analysis of 1,433 patients in the Japanese literature. Am J Surg 140:653–657PubMedCrossRef
3.
go back to reference Wiseman K, Buczkowski AK, Chung SW et al (2005) Epidemiology, presentation, diagnosis, and outcomes of choledochal cysts in adults in an urban environment. Am J Surg 189:527–531PubMedCrossRef Wiseman K, Buczkowski AK, Chung SW et al (2005) Epidemiology, presentation, diagnosis, and outcomes of choledochal cysts in adults in an urban environment. Am J Surg 189:527–531PubMedCrossRef
4.
go back to reference Singhavejsakul J, Ukarapol N (2008) Choledochal cysts in children: epidemiology and outcomes. World J Surg 32:1385–1388PubMedCrossRef Singhavejsakul J, Ukarapol N (2008) Choledochal cysts in children: epidemiology and outcomes. World J Surg 32:1385–1388PubMedCrossRef
5.
go back to reference Singham J, Schaeffer D, Yoshida E et al (2007) Choledochal cysts: analysis of disease pattern and optimal treatment in adult and paediatric patients. HPB 9:383–387PubMedCrossRef Singham J, Schaeffer D, Yoshida E et al (2007) Choledochal cysts: analysis of disease pattern and optimal treatment in adult and paediatric patients. HPB 9:383–387PubMedCrossRef
6.
go back to reference Dhupar R, Gulack B, Geller DA et al (2009) The changing presentation of choledochal cyst disease: an incidental diagnosis. HPB Surg 2009:103739PubMedCrossRef Dhupar R, Gulack B, Geller DA et al (2009) The changing presentation of choledochal cyst disease: an incidental diagnosis. HPB Surg 2009:103739PubMedCrossRef
7.
go back to reference Lipsett PA, Pitt HA, Colombani PM et al (1994) Choledochal cyst disease: a changing pattern of presentation. Ann Surg 220:644–652PubMedCrossRef Lipsett PA, Pitt HA, Colombani PM et al (1994) Choledochal cyst disease: a changing pattern of presentation. Ann Surg 220:644–652PubMedCrossRef
8.
go back to reference Lipsett PA, Pitt HA (2003) Surgical treatment of choledochal cysts. J Hepatobiliary Pancreat Surg 10:352–359PubMedCrossRef Lipsett PA, Pitt HA (2003) Surgical treatment of choledochal cysts. J Hepatobiliary Pancreat Surg 10:352–359PubMedCrossRef
9.
go back to reference Park DH, Kim MH, Lee SK et al (2005) Can MRCP replace the diagnostic role of ERCP for patients with choledochal cysts? Gastrointest Endosc 62:360–366PubMedCrossRef Park DH, Kim MH, Lee SK et al (2005) Can MRCP replace the diagnostic role of ERCP for patients with choledochal cysts? Gastrointest Endosc 62:360–366PubMedCrossRef
10.
go back to reference Lee HK, Park SJ, Yi BH et al (2009) Imaging features of adult choledochal cysts: a pictorial review. Korean J Radiol 10:71–80PubMedCrossRef Lee HK, Park SJ, Yi BH et al (2009) Imaging features of adult choledochal cysts: a pictorial review. Korean J Radiol 10:71–80PubMedCrossRef
11.
go back to reference Cha SW, Park MS, Kim KW et al (2008) Choledochal cyst and anomalous pancreaticobiliary ductal union in adults: radiological spectrum and complications. J Comput Assist Tomogr 32:17–22PubMedCrossRef Cha SW, Park MS, Kim KW et al (2008) Choledochal cyst and anomalous pancreaticobiliary ductal union in adults: radiological spectrum and complications. J Comput Assist Tomogr 32:17–22PubMedCrossRef
12.
go back to reference Trinidad-Hernandez M, Rivera-Perez VS, Hermosillo-Sandoval JM (2007) Adult choledochal cyst. Am J Surg 193:221–222PubMedCrossRef Trinidad-Hernandez M, Rivera-Perez VS, Hermosillo-Sandoval JM (2007) Adult choledochal cyst. Am J Surg 193:221–222PubMedCrossRef
13.
go back to reference Palanivelu C, Rangarajan M, Parthasarathi R et al (2008) Laparoscopic management of choledochal cysts: technique and outcomes—a retrospective study of 35 patients from a tertiary center. J Am Coll Surg 207:839–846PubMedCrossRef Palanivelu C, Rangarajan M, Parthasarathi R et al (2008) Laparoscopic management of choledochal cysts: technique and outcomes—a retrospective study of 35 patients from a tertiary center. J Am Coll Surg 207:839–846PubMedCrossRef
14.
go back to reference Jang JY, Kim SW, Han HS et al (2006) Totally laparoscopic management of choledochal cysts using a four-hole method. Surg Endosc 20:1762–1765PubMedCrossRef Jang JY, Kim SW, Han HS et al (2006) Totally laparoscopic management of choledochal cysts using a four-hole method. Surg Endosc 20:1762–1765PubMedCrossRef
15.
go back to reference Komi N, Tamura T, Miyoshi Y et al (1984) Nationwide survey of cases of choledochal cyst. Analysis of coexistent anomalies, complications and surgical treatment in 645 cases. Surg Gastroenterol 3:69–73PubMed Komi N, Tamura T, Miyoshi Y et al (1984) Nationwide survey of cases of choledochal cyst. Analysis of coexistent anomalies, complications and surgical treatment in 645 cases. Surg Gastroenterol 3:69–73PubMed
16.
go back to reference Yu ZL, Zhang LJ, Fu JZ et al (2004) Anomalous pancreaticobiliary junction: image analysis and treatment principles. Hepatobiliary Pancreat Dis Int 3:136–139PubMed Yu ZL, Zhang LJ, Fu JZ et al (2004) Anomalous pancreaticobiliary junction: image analysis and treatment principles. Hepatobiliary Pancreat Dis Int 3:136–139PubMed
17.
go back to reference Ono Y, Kaneko K, Tainaka T et al (2008) Pancreaticobiliary maljunction without bile duct dilatation in children: distinction from choledochal cyst. J Pediatr Gastroenterol Nutr 46:555–560PubMedCrossRef Ono Y, Kaneko K, Tainaka T et al (2008) Pancreaticobiliary maljunction without bile duct dilatation in children: distinction from choledochal cyst. J Pediatr Gastroenterol Nutr 46:555–560PubMedCrossRef
18.
go back to reference Imazu M, Iwai N, Tokiwa K et al (2001) Factors of biliary carcinogenesis in choledochal cysts. Eur J Pediatr Surg 11:24–27PubMedCrossRef Imazu M, Iwai N, Tokiwa K et al (2001) Factors of biliary carcinogenesis in choledochal cysts. Eur J Pediatr Surg 11:24–27PubMedCrossRef
19.
go back to reference Shimotake T, Iwai N, Yanagihara J et al (1995) Innervation patterns in congenital biliary dilatation. Eur J Pediatr Surg 5:265–270PubMedCrossRef Shimotake T, Iwai N, Yanagihara J et al (1995) Innervation patterns in congenital biliary dilatation. Eur J Pediatr Surg 5:265–270PubMedCrossRef
20.
21.
go back to reference Chaudhary A, Dhar P, Sachdev A et al (1996) Choledochal cysts—differences in children and adults. Br J Surg 83:186–188PubMedCrossRef Chaudhary A, Dhar P, Sachdev A et al (1996) Choledochal cysts—differences in children and adults. Br J Surg 83:186–188PubMedCrossRef
22.
go back to reference Nagorney DM, McIlrath DC, Adson MA (1984) Choledochal cysts in adults: clinical management. Surgery 96:656–663PubMed Nagorney DM, McIlrath DC, Adson MA (1984) Choledochal cysts in adults: clinical management. Surgery 96:656–663PubMed
23.
go back to reference Watanabe Y, Toki A, Todani T (1999) Bile duct cancer developed after cyst excision for choledochal cyst. J Hepatobiliary Pancreat Surg 6:207–212PubMedCrossRef Watanabe Y, Toki A, Todani T (1999) Bile duct cancer developed after cyst excision for choledochal cyst. J Hepatobiliary Pancreat Surg 6:207–212PubMedCrossRef
24.
go back to reference Kang CM, Kim KS, Choi JS et al (2007) Gallbladder carcinoma associated with anomalous pancreaticobiliary duct junction. Can J Gastroenterol 21:383–387PubMed Kang CM, Kim KS, Choi JS et al (2007) Gallbladder carcinoma associated with anomalous pancreaticobiliary duct junction. Can J Gastroenterol 21:383–387PubMed
25.
go back to reference Song HK, Kim MH, Myung SJ et al (1999) Choledochal cyst associated with the anomalous union of pancreaticobiliary duct (AUPBD) has a more grave clinical course than choledochal cyst alone. Korean J Intern Med 14:1–8PubMed Song HK, Kim MH, Myung SJ et al (1999) Choledochal cyst associated with the anomalous union of pancreaticobiliary duct (AUPBD) has a more grave clinical course than choledochal cyst alone. Korean J Intern Med 14:1–8PubMed
26.
go back to reference Kobayashi S, Asano T, Yamasaki M et al (1999) Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery 126:939–944PubMedCrossRef Kobayashi S, Asano T, Yamasaki M et al (1999) Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery 126:939–944PubMedCrossRef
27.
go back to reference Shah OJ, Shera AH, Zargar SA et al (2009) Choledochal cysts in children and adults with contrasting profiles: 11-year experience at a tertiary care center in Kashmir. World J Surg 33:2403–2411PubMedCrossRef Shah OJ, Shera AH, Zargar SA et al (2009) Choledochal cysts in children and adults with contrasting profiles: 11-year experience at a tertiary care center in Kashmir. World J Surg 33:2403–2411PubMedCrossRef
28.
go back to reference Ono S, Sakai K, Kimura O et al (2008) Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg 43:E17–E19PubMedCrossRef Ono S, Sakai K, Kimura O et al (2008) Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg 43:E17–E19PubMedCrossRef
29.
go back to reference Ishibashi T, Kasahara K, Yasuda Y et al (1997) Malignant change in the biliary tract after excision of choledochal cyst. Br J Surg 84:1687–1691PubMedCrossRef Ishibashi T, Kasahara K, Yasuda Y et al (1997) Malignant change in the biliary tract after excision of choledochal cyst. Br J Surg 84:1687–1691PubMedCrossRef
30.
go back to reference Jordan PH Jr, Goss JA Jr, Rosenberg WR et al (2004) Some considerations for management of choledochal cysts. Am J Surg 187:790–795PubMedCrossRef Jordan PH Jr, Goss JA Jr, Rosenberg WR et al (2004) Some considerations for management of choledochal cysts. Am J Surg 187:790–795PubMedCrossRef
31.
go back to reference Kim JH, Choi TY, Han JH et al (2008) Risk factors of postoperative anastomotic stricture after excision of choledochal cysts with hepaticojejunostomy. J Gastrointest Surg 12:822–828PubMedCrossRef Kim JH, Choi TY, Han JH et al (2008) Risk factors of postoperative anastomotic stricture after excision of choledochal cysts with hepaticojejunostomy. J Gastrointest Surg 12:822–828PubMedCrossRef
32.
go back to reference Ando H, Kaneko K, Ito T et al (1996) Complete excision of the intrapancreatic portion of choledochal cysts. J Am Coll Surg 183:317–321PubMed Ando H, Kaneko K, Ito T et al (1996) Complete excision of the intrapancreatic portion of choledochal cysts. J Am Coll Surg 183:317–321PubMed
33.
go back to reference Miyano T, Yamataka A, Kato Y et al (1995) Choledochal cysts: special emphasis on the usefulness of intraoperative endoscopy. J Pediatr Surg 30:482–484PubMedCrossRef Miyano T, Yamataka A, Kato Y et al (1995) Choledochal cysts: special emphasis on the usefulness of intraoperative endoscopy. J Pediatr Surg 30:482–484PubMedCrossRef
34.
go back to reference Nakayama H, Masuda H, Ugajin W et al (2000) Left hepatic lobectomy for type IV-A choledochal cyst. Am Surg 66:1020–1022PubMed Nakayama H, Masuda H, Ugajin W et al (2000) Left hepatic lobectomy for type IV-A choledochal cyst. Am Surg 66:1020–1022PubMed
35.
go back to reference Kanoh K, Shimura T, Tsutsumi S et al (2002) Left hepatectomy for the choledochal cyst (type IV-A) with intrahepatic stenosis: report of a case. Hepatogastroenterology 49:144–147PubMed Kanoh K, Shimura T, Tsutsumi S et al (2002) Left hepatectomy for the choledochal cyst (type IV-A) with intrahepatic stenosis: report of a case. Hepatogastroenterology 49:144–147PubMed
36.
go back to reference Kawarada Y, Das BC, Tabata M et al (2009) Surgical treatment of type IV choledochal cysts. J Hepatobiliary Pancreat Surg 16:684–687PubMedCrossRef Kawarada Y, Das BC, Tabata M et al (2009) Surgical treatment of type IV choledochal cysts. J Hepatobiliary Pancreat Surg 16:684–687PubMedCrossRef
37.
go back to reference Millwala F, Segev DL, Thuluvath PJ (2008) Caroli’s disease and outcomes after liver transplantation. Liver Transpl 14:11–17PubMedCrossRef Millwala F, Segev DL, Thuluvath PJ (2008) Caroli’s disease and outcomes after liver transplantation. Liver Transpl 14:11–17PubMedCrossRef
38.
go back to reference De Kerckhove L, De Meyer M, Verbaandert C et al (2006) The place of liver transplantation in Caroli’s disease and syndrome. Transpl Int 19:381–388PubMedCrossRef De Kerckhove L, De Meyer M, Verbaandert C et al (2006) The place of liver transplantation in Caroli’s disease and syndrome. Transpl Int 19:381–388PubMedCrossRef
39.
40.
go back to reference Sikora SS, Singh RK (2006) Surgical strategies in patients with gallbladder cancer: nihilism to optimism. J Surg Oncol 93:670–681PubMedCrossRef Sikora SS, Singh RK (2006) Surgical strategies in patients with gallbladder cancer: nihilism to optimism. J Surg Oncol 93:670–681PubMedCrossRef
41.
go back to reference Jang JY, Kim SW, Park DJ et al (2005) Actual long-term outcome of extrahepatic bile duct cancer after surgical resection. Ann Surg 241:77–84PubMed Jang JY, Kim SW, Park DJ et al (2005) Actual long-term outcome of extrahepatic bile duct cancer after surgical resection. Ann Surg 241:77–84PubMed
42.
go back to reference Lee SG, Song GW, Hwang S et al (2010) Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 17:476–489PubMedCrossRef Lee SG, Song GW, Hwang S et al (2010) Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 17:476–489PubMedCrossRef
Metadata
Title
Surgical Experience of 204 Cases of Adult Choledochal Cyst Disease over 14 Years
Authors
Min-Jeong Cho
Shin Hwang
Young-Joo Lee
Ki-Hun Kim
Chul-Soo Ahn
Deok-Bog Moon
Sung-Koo Lee
Myung-Hwan Kim
Sang-Soo Lee
Do-Hyun Park
Sung-Gyu Lee
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 5/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-011-1009-7

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