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Published in:

01-08-2011

Expression and Function of a Large Non-coding RNA Gene XIST in Human Cancer

Published in: World Journal of Surgery | Issue 8/2011

Abstract

Background

X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males. X inactive-specific transcript expression has been found to be dysregulated in a variety of human cancers when compared to normal cells; meanwhile, the inactivated X chromosome has been noted to be conspicuously absent in human cancer specimens, whereas X chromosome duplications are widely noted. The specific pathways whereby changes in X chromosome status and XIST expression occur in cancer remain incompletely described. Nevertheless, a role for XIST in BRCA1-mediated epigenetic activity has been proposed.

Methods

Here we review the data regarding XIST expression and X chromosome status in a variety of female, male, and non–sex-related human cancers.

Conclusions

It is not yet known whether X chromosome duplication, XIST dysregulation, and over-expression of X-linked genes represent important factors in tumorgenesis or are simply a consequence of overall epigenetic instability in these cancers.

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Title: Expression and Function of a Large Non-coding RNA Gene XIST in Human Cancer
Publication date: 01-08-2011
Published in: World Journal of Surgery / Issue 8/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0951-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Expression and Function of a Large Non-coding RNA Gene XIST in Human Cancer

Abstract

Background

Methods

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Conclusions

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