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World Journal of Surgery

Published in:

01-05-2010

Clinical Significance of B7-H1 and B7-1 Expressions in Pancreatic Carcinoma

Authors: Liancai Wang, Qingyong Ma, Xiangli Chen, Kun Guo, Junhui Li, Min Zhang

Published in: World Journal of Surgery | Issue 5/2010

Abstract

Background

Cancer cells develop mechanisms to evade immune cells and achieve progression. Aberrant B7-H1 and B7-1 expressions may help pancreatic carcinoma (PC) cells escape immune attack; these molecules can be considered as prognostic markers for patients with PC who have undergone radical resection.

Methods

We recruited 81 patients who had undergone radical surgical resection for PC between 1999 and 2007. To investigate the prognostic factors, we evaluated the B7-H1 and B7-1 protein expressions in the tissue specimens of these 81 patients by immunohistochemistry and analyzed the clinical and pathological features of these specimens.

Results

B7-H1 was expressed mainly in pancreatic islets, and no B7-1 expression was detected in normal pancreatic tissues. B7-H1 and B7-1 expressions were higher in pancreatic carcinoma tissues than in normal pancreatic tissues (P < 0.05). B7-H1 and B7-1 significantly correlated with the pathological grade and tumor-node-metastasis (TNM) stage, respectively (P < 0.05). Furthermore, B7-1-negative or B7-H1-positive statuses were prognostic indicators of poor disease-specific survival (P < 0.05), but only combined B7-1/B7-H1 expression retained the prognostic potential after adjusting by Cox proportional hazards regression models (P < 0.05).

Conclusions

Both B7-H1 and B7-1 are expressed in PC; these molecules are important markers for PC progression. Furthermore, combined B7-1/B7-H1 expression can serve as an independent prognostic marker for PC.

Ichikawa M, Chen L (2005) Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms. Front Biosci 10:2856–2860CrossRefPubMed

Geng L, Huang D, Liu J et al (2008) B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression. J Cancer Res Clin Oncol 134:1021–1027CrossRefPubMed

Choi IH, Zhu G, Sica GL et al (2003) Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J Immunol 171:4650–4654PubMed

Krambeck AE, Dong H, Thompson RH et al (2007) Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Clin Cancer Res 13:1749–1756CrossRefPubMed

Ghebeh H, Tulbah A, Mohammed S et al (2007) Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells. Int J Cancer 121:751–758CrossRefPubMed

Dong H, Strome SE, Salomao DR et al (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8:793–800PubMed

Strome SE, Dong H, Tamura H et al (2003) B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res 63:6501–6505PubMed

Chen L (2004) Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 4:336–347CrossRefPubMed

Curiel TJ, Wei S, Dong H et al (2003) Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 9:562–567CrossRefPubMed

10.

Hirano F, Kaneko K, Tamura H et al (2005) Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 65:1089–1096PubMed

11.

Lukens JR, Cruise MW, Lassen MG et al (2008) Blockade of PD-1/B7-H1 interaction restores effector CD8+ t cell responses in a hepatitis C virus core murine model. J Immunol 180:4875–4884PubMed

12.

Blank C, Kuball J, Voelkl S et al (2006) Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. Int J Cancer 119:317–327CrossRefPubMed

13.

Brown JA, Dorfman DM, Ma FR et al (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170:1257–1266PubMed

14.

Hicks C, Keoshkerian E, Gaudry L et al (2001) CD80 (B7-1) expression on human acute myeloid leukemic cells cultured with GM-CSF, IL-3 and IL-6. Cancer Immunol Immunother 50:173–180CrossRefPubMed

15.

Tirapu I, Huarte E, Guiducci C et al (2006) Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Res 66:2442–2450CrossRefPubMed

16.

Esposito I, Friess H, Buchler MW (2001) Molecular mechanisms in chronic pancreatitis. Zentralbl Chir 126:867–872CrossRefPubMed

17.

Yadav D, Fine C, Azuma M et al (2007) B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol Immunol 44:2616–2624CrossRefPubMed

18.

Putzer BM, Rodicker F, Hitt MM et al (2002) Improved treatment of pancreatic cancer by IL-12 and B7.1 costimulation: antitumor efficacy and immunoregulation in a nonimmunogenic tumor model. Mol Ther 5:405–412CrossRefPubMed

19.

Antonia SJ, Munoz-Antonia T, Soldevila G et al (1995) B7-1 expression by a non-antigen presenting cell-derived tumor. Cancer Res 55:2253–2256PubMed

20.

Nagakawa T, Kayahara M, Ueno K et al (1992) A clinicopathologic study on neural invasion in cancer of the pancreatic head. Cancer 69:930–935CrossRefPubMed

21.

Zou W (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 5:263–274CrossRefPubMed

22.

Dunn GP, Koebel CM, Schreiber RD (2006) Interferons, immunity and cancer immunoediting. Nat Rev Immunol 6:836–848CrossRefPubMed

23.

Azuma T, Yao S, Zhu G et al (2008) B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111:3635–3643CrossRefPubMed

24.

DiPaola RS, Plante M, Kaufman H et al (2006) A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer. J Transl Med 4:1CrossRefPubMed

25.

Chen M, Si H, Si L et al. (2000) Immunocytochemistry study of b7.1 in six tumor cell lines. Teratog Carcinog Mutagen 219–220

26.

Loos M, Giese NA, Kleeff J et al (2008) Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer. Cancer Lett 268:98–109CrossRefPubMed

27.

Marco GS, Colucci JA, Fernandes FB et al (2008) Diabetes induces changes of catecholamines in primary mesangial cells. Int J Biochem Cell Biol 40:747–754CrossRefPubMed

28.

Tentolouris N, Argyrakopoulou G, Katsilambros N (2008) Perturbed autonomic nervous system function in metabolic syndrome. Neuromolecular Med 10:169–178CrossRefPubMed

29.

Hong SP, Jeong MG, Lim DY (2007) Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla. J Cardiol 50:351–362PubMed

30.

Straub RH, Harle P (2005) Stress, hormones, and neuronal signals in the pathophysiology of rheumatoid arthritis. The negative impact on chronic inflammation. Med Klin (Munich) 100:794–803CrossRef

31.

Reiche EM, Morimoto HK, Nunes SM (2005) Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry 17:515–527CrossRefPubMed

32.

Reiche EM, Nunes SO, Morimoto HK (2004) Stress, depression, the immune system, and cancer. Lancet Oncol 5:617–625CrossRefPubMed

Title: Clinical Significance of B7-H1 and B7-1 Expressions in Pancreatic Carcinoma
Authors: Liancai Wang
Qingyong Ma
Xiangli Chen
Kun Guo
Junhui Li
Min Zhang
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 5/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0448-x

ACC 2024 Congress

Springer Medicine

Clinical Significance of B7-H1 and B7-1 Expressions in Pancreatic Carcinoma

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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