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World Journal of Surgery
Published in: World Journal of Surgery 4/2009

01-04-2009

Developing a Tissue Resource to Characterize the Genome of Pancreatic Cancer

Authors: Georgios Voidonikolas, Marie-Claude Gingras, Sally Hodges, Amy L. McGuire, Changyi Chen, Richard A. Gibbs, F. Charles Brunicardi, William E. Fisher

Published in: World Journal of Surgery | Issue 4/2009

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Abstract

With recent advances in DNA sequencing technology, medicine is entering an era in which a personalized genomic approach to diagnosis and treatment of disease is feasible. However, discovering the role of altered DNA sequences in various disease states will be a challenging task. The genomic approach offers great promise for diseases, such as pancreatic cancer, in which the effect of current diagnostic and treatment modalities is disappointing. To facilitate the characterization of the genome of pancreatic cancer, high-quality and well-annotated tissue repositories are needed. This article summarizes the basic principles that guide the creation of such a repository, including sample processing and preservation techniques, sample size and composition, and collection of clinical data elements.
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Metadata
Title
Developing a Tissue Resource to Characterize the Genome of Pancreatic Cancer
Authors
Georgios Voidonikolas
Marie-Claude Gingras
Sally Hodges
Amy L. McGuire
Changyi Chen
Richard A. Gibbs
F. Charles Brunicardi
William E. Fisher
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 4/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-008-9877-1

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