Published in:
01-04-2009
Overview of the Molecular Surgeon Symposium on Personalized Genomic Medicine and Surgery
Published in: World Journal of Surgery | Issue 4/2009
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The Michael E. DeBakey Department Surgery at Baylor College of Medicine, Houston, Texas, was awarded a R13 grant (CA132572) from the National Institutes of Health and proudly hosted “Molecular Surgeon Symposium on Personalized Genomic Medicine and Surgery” at the Baylor College of Medicine campus on April 12, 2008. The overall goal of this interdisciplinary scientific symposium was to bring together outstanding surgeons, physicians, and scientists from diverse fields with a common interest in genomics and cancer. Nineteen invited speakers presented and discussed their latest advances in multiple research topics, including genome DNA sequence and analysis, models of personalized genomic research, tissue banking, biomarkers and pathways, gene polymorphism, molecular imaging, ethical considerations, protein quantification, gene therapy, and many critical genes and their functions (PDX-1, ZIP4, GATA6, K-ras, CXCR2, RET, mesothelin, TGF-β and non-coding RNA genes; Table 1). The symposium also provided a unique opportunity for trainees, including postdoctoral fellows, clinical residents and fellows, medical students, graduate students, and other scientists, to interact with these outstanding investigators in the area of cancer genomics and genetics. At the symposium’s conclusion, participants achieved the following specific objectives: (1) understand the impact and opportunities of personalized genomics on cancer research; (2) discuss recent scientific advances related to molecular pathogenesis, diagnosis, and therapy for cancer; (3) determine the future directions of personalized genomic research in medicine and surgery; and (4) establish a collaborative network in cancer genomic research.
Table 1
Invited speakers at the Molecular Surgeon Symposium on Personalized Genomic Medicine and Surgery
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Speaker
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Institution and position
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Presentation
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|---|---|---|
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Richard A. Gibbs, Ph.D.
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Wofford Cain Professor, Department of Molecular and Human Genetics, Director, Human Genome Sequencing Center, Baylor College of Medicine
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Personal genomes and genetic diagnosis
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F. Charles Brunicardi, M.D.
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DeBakey/Bard Chair Professor of Surgery, and Chair of Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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PDX-1 as a prototype for personalized genomic medicine and surgery
|
|
William E. Fisher, M.D.
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Associate Professor of Surgery, Director of the Elkins Pancreas Center Michael E. DeBakey Department of Surgery, Baylor College of Medicine
|
Building an ideal tissue resource for genomic research
|
|
Marie-Claude Gingras, Ph.D.
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Assistant Professor, Department of Molecular and Human Genetics, Human Genome Sequence Center, Baylor College of Medicine
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Using 454 pyrosequencing technology for mutation discovery in cancer
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|
Sean J. Mulvihill, M.D.
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Ross Anderson Presidential Endowed Chair in Surgery, Professor of Surgery, Chairman of Department of Surgery, Senior Director for Clinical Affairs – Huntsman Cancer Institute, University of Utah School of Medicine
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Biomarker discovery through pathway analysis
|
|
Donghui Li, Ph.D.
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Associate Professor, Department of GI Medical Oncology, Virginia Harris Cockrell Cancer Research Center, University of Texas M. D. Anderson Cancer Center
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DNA repair gene polymorphism and pancreatic cancer survival
|
|
Min Li, Ph.D.
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Assistant Professor of Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Zinc transporter ZIP4 and pancreatic cancer
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Eva M. Sevick-Muraca, Ph.D.
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Professor and Division Head, Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine
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In vivo molecular imaging of gene expression using NIR fluorescent and PET agents
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|
David H. Berger, M.D., M.H.C.M.
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Professor and Vice Chair, Chief of Division of General Surgery and Surgical Oncology, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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GATA6: a new molecular target in colorectal cancer
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|
Changyi Chen, M.D., Ph.D.
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Molecular Surgery Chair Professor of Surgery and Molecular and Cellular Biology, Director of the Molecular Surgeon Research Center, Vice Chair for Research, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Non-coding RNA genes and pancreatic cancer
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|
A. James Moser, M.D.
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Assistant Professor of Surgery, Department of Surgery, University of Pittsburgh Medical Center
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Clinical and translational research at the UPMC pancreatic cancer center
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Xiaoliu “Shaun” Zhang, Ph.D.
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Associate Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
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Oncolytic agents targeting K-ras mutations in pancreatic cancer
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O. Joe Hines, M.D.
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Associate Professor of Surgery, Department of Surgery, University of California, Los Angeles
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Role of CXCR2 and RET in pancreatic cancer
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Qizhi Yao, M.D., Ph.D.
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Professor of Surgery and Molecular Virology, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Mesothelin and pancreatic cancer
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Daniel Albo, M.D., Ph.D.
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Associate Professor of Surgery, Division of General Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Genomics in colorectal cancer: present and future directions
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Xia Lin, Ph.D.
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Assistant Professor of Surgery, Division of General Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Turning off TGFbeta signaling via phosphatase PPM1A
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Amy McGuire, Ph.D.
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Assistant Professor, Center for Ethics and Health Policies, Baylor College of Medicine
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Personalized genomic medicine: ethical considerations
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Gustavo E. Ayala, M.D.
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Professor of Pathology, Department of Pathology, Baylor College of Medicine
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From genomics to novel methods of protein quantification
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Nancy Smyth Templeton, Ph.D.
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Assistant professor of Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
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Nonviral delivery for genomic therapy of cancer
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