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01-11-2007

Clinical Significance of Perioperative Immunonutrition for Patients with Esophageal Cancer

Authors: Hiroya Takeuchi, Shunji Ikeuchi, Yoshiki Kawaguchi, Yuko Kitagawa, Yoh Isobe, Kiyoshi Kubochi, Masaki Kitajima, Sumio Matsumoto

Published in: World Journal of Surgery | Issue 11/2007

Abstract

Background

We hypothesized that preoperative and/or postoperative enteral immune-enhanced formulas that are supplemented with arginine, omega-3 fatty acids, and RNA may reduce postoperative complications in patients undergoing esophagectomy for thoracic esophageal squamous cell carcinoma (ESCC).

Methods

Forty patients who underwent esophagectomy were divided into three groups: group A (n = 20) received a control enteral diet (Erental) through the jejunostomy after surgery. group B (n = 6) received an enteral diet supplemented with immune-enhancing substrates (Impact) containing arginine, omega-3 fatty acids, and RNA after surgery. group C (n = 14) received the impact before and after surgery.

Results

Lymphocyte counts in group C on postoperative day (POD) 7 were somewhat higher than that in group A (p = 0.07) and significantly higher than in group B (p = 0.03). Furthermore the incidence of incisional wound infection in group C was significantly lower than that in group A (p = 0.03). Moreover, the duration of postoperative systemic inflammatory response syndrome (SIRS) was significantly shorter in group C than in group A (p < 0.05).

Conclusions

This study reveals that the perioperative immune-enhanced formula may be superior to postoperative control enteral formulas in terms of reducing surgical wound infection and postoperative SIRS, which may result in serious postoperative complications for patients who have undergone esophagectomy.

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Title: Clinical Significance of Perioperative Immunonutrition for Patients with Esophageal Cancer
Authors: Hiroya Takeuchi
Shunji Ikeuchi
Yoshiki Kawaguchi
Yuko Kitagawa
Yoh Isobe
Kiyoshi Kubochi
Masaki Kitajima
Sumio Matsumoto
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 11/2007
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-007-9219-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical Significance of Perioperative Immunonutrition for Patients with Esophageal Cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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