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Published in:

01-04-2006

Does Resection Line Involvement Affect Prognosis in Early Gastric Cancer Patients? An Italian Multicentric Study

Authors: Paolo Morgagni, MD, Domenico Garcea, MD, Daniele Marrelli, MD, Giovanni de Manzoni, MD, Giovanni Natalini, MD, Hayato Kurihara, MD, Alberto Marchet, MD, Giovanni Vittimberga, MD, Luca Saragoni, MD, Franco Roviello, MD, Alberto Di Leo, MD, Francesco De Santis, MD, Valerio Panizza, MD, Donato Nitti, MD

Published in: World Journal of Surgery | Issue 4/2006

Abstract

Background

Resection line involvement has been indicated as an important prognostic factor for gastric cancer. Its late detection renders the choice of treatment difficult for surgeons.

Materials and Methods

We describe the multicenter experience of a group of 11 patients with early gastric carcinoma (EGC) and positive resection confirmed at histological examination who did not undergo surgical retreatment for reasons of associated disease, surgical considerations on duodenal stump, or patient refusal.

Results

The gastric margin was involved in 4 patients, and 7 patients had duodenal resection line involvement. No surgical complications or postoperative deaths were observed. Five and 8-year survival was 100% and 86%, respectively. The only patient who relapsed did not have lymph node involvement and died from liver metastases, without local recurrence.

Conclusions

It is sometimes difficult to accurately define the resection line in gastric cancer surgery, especially in the early stages of disease, but because of the strongly negative prognostic value of an infiltrated margin, frozen sections are recommended if neoplastic invasion is suspected and a new resection is always recommended if possible. Nevertheless, the good prognosis of resected EGC patients with resection line involvement must be considered before submitting patients with associated diseases to radical surgical retreatment.

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Title: Does Resection Line Involvement Affect Prognosis in Early Gastric Cancer Patients? An Italian Multicentric Study
Authors: Paolo Morgagni, MD
Domenico Garcea, MD
Daniele Marrelli, MD
Giovanni de Manzoni, MD
Giovanni Natalini, MD
Hayato Kurihara, MD
Alberto Marchet, MD
Giovanni Vittimberga, MD
Luca Saragoni, MD
Franco Roviello, MD
Alberto Di Leo, MD
Francesco De Santis, MD
Valerio Panizza, MD
Donato Nitti, MD
Publication date: 01-04-2006
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 4/2006
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-005-7975-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Does Resection Line Involvement Affect Prognosis in Early Gastric Cancer Patients? An Italian Multicentric Study

Abstract

Background

Materials and Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Materials and Methods

Results

Conclusions

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