Skip to main content
Top
Published in: World Journal of Surgery 7/2003

01-07-2003 | Original Scientific Reports

Selective Hepatic Vascular Exclusion versus Pringle Maneuver in Major Liver Resections: Prospective Study

Authors: Vassilios E. Smyrniotis, M.D., Ph.D., Georgia G. Kostopanagiotou, M.D., Ph.D., John C. Contis, M.D., Ph.D., Charalampos I. Farantos, M.D., Dionisios C. Voros, M.D., Ph.D., Dimitrios C. Kannas, M.D., Ph.D., John S. Koskinas, M.D., Ph.D.

Published in: World Journal of Surgery | Issue 7/2003

Login to get access

Abstract

Selective hepatic vascular exclusion (SHVE) and the Pringle maneuver are two methods used to control bleeding during hepatectomy. They are compared in a prospective randomized study, where 110 patients undergoing major liver resection were randomly allocated to the SHVE group or the Pringle group. Data regarding the intraoperative and postoperative courses of the patients are analyzed. Intraoperative blood loss and transfusion requirements were significantly decreased in the SHVE group, and postoperative liver function was better in that group. Although there was no difference between the two groups regarding the postoperative complications rate, patients offered the Pringle maneuver had a significantly longer hospital stay. The application of SHVE did not prolong the warm ischemia time or the total operating time. It is evident from the present study that SHVE performed by experienced surgeons is as safe as the Pringle maneuver and is well tolerated by the patients. It is much more effective than the Pringle maneuver for controlling intraoperative bleeding, and it is associated with better postoperative liver function and shorter hospital stay.
Literature
1.
go back to reference Gozzetti, G, Mazziotti, A, Grazi, GL, et al. 1995Liver resection without blood transfusionBr. J. Surg.8211051110PubMed Gozzetti, G, Mazziotti, A, Grazi, GL,  et al. 1995Liver resection without blood transfusionBr. J. Surg.8211051110PubMed
2.
go back to reference Yamamoto, J, Kosuge, T, Takayama, T, et al. 1994Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomySurgery115303309PubMed Yamamoto, J, Kosuge, T, Takayama, T,  et al. 1994Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomySurgery115303309PubMed
3.
go back to reference Shimada, M, Matsumata, T, Akazawa, K, et al. 1994Estimation of risk of major complications after hepatic resectionAm. J. Surg.167399403PubMed Shimada, M, Matsumata, T, Akazawa, K,  et al. 1994Estimation of risk of major complications after hepatic resectionAm. J. Surg.167399403PubMed
4.
go back to reference Cunningham, JD, Fong, Y, Shriven, C, et al. 1994One hundred consecutive hepatic resections: blood loss, transfusion and operative techniqueArch. Surg.12910501056PubMed Cunningham, JD, Fong, Y, Shriven, C,  et al. 1994One hundred consecutive hepatic resections: blood loss, transfusion and operative techniqueArch. Surg.12910501056PubMed
5.
go back to reference Berney, T, Mentha, G, Morel, P 1998Total vascular exclusion of the liver for the resection of lesions in contact with the vena cava or the hepatic veinsBr. J. Surg.85485488CrossRefPubMed Berney, T, Mentha, G, Morel, P 1998Total vascular exclusion of the liver for the resection of lesions in contact with the vena cava or the hepatic veinsBr. J. Surg.85485488CrossRefPubMed
6.
go back to reference Miyazaki, M, Ho, H, Nakagawa, K, et al. 1999Aggressive surgical resection for hepatic metastases involving the inferior vena cavaAm. J. Surg.177294298CrossRefPubMed Miyazaki, M, Ho, H, Nakagawa, K,  et al. 1999Aggressive surgical resection for hepatic metastases involving the inferior vena cavaAm. J. Surg.177294298CrossRefPubMed
7.
go back to reference Habib, NA, Michail, NE, Boyle, T, et al. 1994Resection of the inferior vena cava during hepatectomy for liver tumorsBr. J. Surg.8110231024PubMed Habib, NA, Michail, NE, Boyle, T,  et al. 1994Resection of the inferior vena cava during hepatectomy for liver tumorsBr. J. Surg.8110231024PubMed
8.
go back to reference Delva, E, Camus, Y, Nordlinger, B, et al. 1989Vascular occlusions for liver resections: operative management and tolerance to hepatic ischemia: 142 casesAnn. Surg.209211218PubMed Delva, E, Camus, Y, Nordlinger, B,  et al. 1989Vascular occlusions for liver resections: operative management and tolerance to hepatic ischemia: 142 casesAnn. Surg.209211218PubMed
9.
go back to reference Huguet, C, Gavelli, A, Chieco, PA, et al. 1992Liver ischemia for hepatic resection: where is the limit?Surgery111251259PubMed Huguet, C, Gavelli, A, Chieco, PA,  et al. 1992Liver ischemia for hepatic resection: where is the limit?Surgery111251259PubMed
10.
go back to reference Elias, D, Desruennes, E, Lasser, P 1991Prolonged intermittent clamping of the portal triad during hepatectomyBr. J. Surg.784244PubMed Elias, D, Desruennes, E, Lasser, P 1991Prolonged intermittent clamping of the portal triad during hepatectomyBr. J. Surg.784244PubMed
11.
go back to reference Hannoun, L, Borie, D, Delva, E, et al. 1993Liver resection with normothermic ischaemia exceeding 1 hBr. J. Surg.8011611165PubMed Hannoun, L, Borie, D, Delva, E,  et al. 1993Liver resection with normothermic ischaemia exceeding 1 hBr. J. Surg.8011611165PubMed
12.
go back to reference Man, K, Fan, ST, Ng, IOL, et al. 1997Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized studyAnn. Surg.226704713CrossRefPubMed Man, K, Fan, ST, Ng, IOL,  et al. 1997Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized studyAnn. Surg.226704713CrossRefPubMed
13.
go back to reference Man, K, Fan, ST, Ng, IOL, et al. 1999Tolerance of the liver to intermittent Pringle maneuver in hepatectomy for liver tumorsArch. Surg.134533539CrossRefPubMed Man, K, Fan, ST, Ng, IOL,  et al. 1999Tolerance of the liver to intermittent Pringle maneuver in hepatectomy for liver tumorsArch. Surg.134533539CrossRefPubMed
14.
go back to reference Belghiti, J, Noun, R, Malafosse, R, et al. 1999Continuous versus intermittent portal triad clamping for liver resection: a controlled studyAnn. Surg.229369375CrossRefPubMed Belghiti, J, Noun, R, Malafosse, R,  et al. 1999Continuous versus intermittent portal triad clamping for liver resection: a controlled studyAnn. Surg.229369375CrossRefPubMed
15.
go back to reference Wu, CC, Hwang, CR, Liu, TJ, et al. 1996Effects and limitations of prolonged intermittent ischaemia for hepatic resection of the cirrhotic liverBr. J. Surg.83121124 Wu, CC, Hwang, CR, Liu, TJ,  et al. 1996Effects and limitations of prolonged intermittent ischaemia for hepatic resection of the cirrhotic liverBr. J. Surg.83121124
16.
go back to reference Grazi, GL, Mazzioti, A, Jovine, E, et al. 1997Total vascular exclusion of the liver during hepatic surgery: selective use, extensive use, or abuse?Arch. Surg.13211041109PubMed Grazi, GL, Mazzioti, A, Jovine, E,  et al. 1997Total vascular exclusion of the liver during hepatic surgery: selective use, extensive use, or abuse?Arch. Surg.13211041109PubMed
17.
go back to reference Cherqui, D, Malassagne, B, Colau, PI, et al. 1999Hepatic vascular exclusion with preservation of caval flow for liver resectionsAnn. Surg.2302430CrossRefPubMed Cherqui, D, Malassagne, B, Colau, PI,  et al. 1999Hepatic vascular exclusion with preservation of caval flow for liver resectionsAnn. Surg.2302430CrossRefPubMed
18.
go back to reference Belghiti, J, Noun, R, Zante, E, et al. 1996Portal triad clamping or hepatic vascular exclusion for major liver resection: a controlled studyAnn. Surg.224155161CrossRefPubMed Belghiti, J, Noun, R, Zante, E,  et al. 1996Portal triad clamping or hepatic vascular exclusion for major liver resection: a controlled studyAnn. Surg.224155161CrossRefPubMed
19.
go back to reference Torzilli, G, Makuuchi, M, Midorikawa, Y, et al. 2001Liver resection without total vascular exclusion: hazardous or beneficial? An analysis of our experienceAnn. Surg.233167175CrossRefPubMed Torzilli, G, Makuuchi, M, Midorikawa, Y,  et al. 2001Liver resection without total vascular exclusion: hazardous or beneficial? An analysis of our experienceAnn. Surg.233167175CrossRefPubMed
20.
go back to reference Smyrniotis, VE, Kostopanagiotou, GG, Gamaletsos, EL, et al. 2002Total versus selective hepatic vascular exclusion in major liver resectionsAm. J. Surg.183173178CrossRefPubMed Smyrniotis, VE, Kostopanagiotou, GG, Gamaletsos, EL,  et al. 2002Total versus selective hepatic vascular exclusion in major liver resectionsAm. J. Surg.183173178CrossRefPubMed
21.
go back to reference Staren, ED, Gambla, M, Deziel, DJ, et al. 1997Intraoperative ultrasound in the management of liver neoplasmsAm. Surg.63591597PubMed Staren, ED, Gambla, M, Deziel, DJ,  et al. 1997Intraoperative ultrasound in the management of liver neoplasmsAm. Surg.63591597PubMed
22.
23.
go back to reference Peralta, C, Hotter, G, Closa, D, et al. 1997Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: role of nitric oxide and adenosineHepatology25934937PubMed Peralta, C, Hotter, G, Closa, D,  et al. 1997Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: role of nitric oxide and adenosineHepatology25934937PubMed
24.
go back to reference Lai, ECS, Fan, ST, Lo, CM, et al. 1996Anterior approach for difficult major right hepatectomyWorld J. Surg.20314318CrossRefPubMed Lai, ECS, Fan, ST, Lo, CM,  et al. 1996Anterior approach for difficult major right hepatectomyWorld J. Surg.20314318CrossRefPubMed
25.
go back to reference Yamamoto, J, Kosuge, T, Shimada, K, et al. 1999Anterior transhepatic approach for isolated resection of the caudate lobe of the liverWorld J. Surg.2397101CrossRefPubMed Yamamoto, J, Kosuge, T, Shimada, K,  et al. 1999Anterior transhepatic approach for isolated resection of the caudate lobe of the liverWorld J. Surg.2397101CrossRefPubMed
26.
go back to reference Hatano, Y, Murakawa, M, Segawa, H, et al. 1990Venous air embolism during hepatic resectionAnesthesiology7312821285PubMed Hatano, Y, Murakawa, M, Segawa, H,  et al. 1990Venous air embolism during hepatic resectionAnesthesiology7312821285PubMed
27.
go back to reference Emre, S, Schwartz, M, Katz, E, et al. 1993Liver resection under total vascular isolation: variations on a themeAnn. Surg.2171519PubMed Emre, S, Schwartz, M, Katz, E,  et al. 1993Liver resection under total vascular isolation: variations on a themeAnn. Surg.2171519PubMed
28.
go back to reference Huguet, C, Addario-Chieco, P, Gavelli, A, et al. 1992Technique of hepatic vascular exclusion for extensive liver resectionAm. J. Surg.163602605PubMed Huguet, C, Addario-Chieco, P, Gavelli, A,  et al. 1992Technique of hepatic vascular exclusion for extensive liver resectionAm. J. Surg.163602605PubMed
29.
go back to reference Yamaoka, Y, Ozawa, K, Kumada, K, et al. 1992Total vascular exclusion for hepatic resection in cirrhotic patients: application of venovenous bypassArch. Surg.127276280PubMed Yamaoka, Y, Ozawa, K, Kumada, K,  et al. 1992Total vascular exclusion for hepatic resection in cirrhotic patients: application of venovenous bypassArch. Surg.127276280PubMed
30.
go back to reference Cosmo, GA, Adducci, E, Gualtieri, EM 2000Haemodynamic and metabolic changes during major liver resection with use of hepatic total vascular exclusionInt. Surg.85243247PubMed Cosmo, GA, Adducci, E, Gualtieri, EM 2000Haemodynamic and metabolic changes during major liver resection with use of hepatic total vascular exclusionInt. Surg.85243247PubMed
31.
go back to reference Elias, D, Lasser, P, Debaene, B, et al. 1995Intermittent vascular exclusion of the liver (without vena cava clamping) during major hepatectomyBr. J. Surg.8215351539PubMed Elias, D, Lasser, P, Debaene, B,  et al. 1995Intermittent vascular exclusion of the liver (without vena cava clamping) during major hepatectomyBr. J. Surg.8215351539PubMed
32.
go back to reference Malassagne, B, Cherqui, D, Alon, R, et al. 1998Safety of selective vascular clamping for major hepatectomiesJ. Am. Coll. Surg.187482486CrossRefPubMed Malassagne, B, Cherqui, D, Alon, R,  et al. 1998Safety of selective vascular clamping for major hepatectomiesJ. Am. Coll. Surg.187482486CrossRefPubMed
33.
go back to reference Midorikawa, Y, Kubota, K, Takayama, T, et al. 1999A comparative study of postoperative complications after hepatectomy in patients with and without chronic liver diseaseSurgery126484494CrossRefPubMed Midorikawa, Y, Kubota, K, Takayama, T,  et al. 1999A comparative study of postoperative complications after hepatectomy in patients with and without chronic liver diseaseSurgery126484494CrossRefPubMed
34.
go back to reference Nakamura, S, Sakaguchi, S, Kitazawa, T, et al. 1990Hepatic vein reconstruction for preserving remnant liver functionArch. Surg.12514551459PubMed Nakamura, S, Sakaguchi, S, Kitazawa, T,  et al. 1990Hepatic vein reconstruction for preserving remnant liver functionArch. Surg.12514551459PubMed
35.
go back to reference Nakamura, S, Sakaguchi, S, Hachiya, T, et al. 1993Significance of hepatic vein reconstruction in hepatectomySurgery1145964PubMed Nakamura, S, Sakaguchi, S, Hachiya, T,  et al. 1993Significance of hepatic vein reconstruction in hepatectomySurgery1145964PubMed
36.
go back to reference Takayama, T, Nakatsuka, T, Yamamoto, J, et al. 1996Re-reconstruction of a single remnant hepatic veinBr. J. Surg.83762763 Takayama, T, Nakatsuka, T, Yamamoto, J,  et al. 1996Re-reconstruction of a single remnant hepatic veinBr. J. Surg.83762763
37.
go back to reference Smyrniotis, V, Arkadopoulos, N, Kehagias, D, et al. 2002Liver resection with repair of major hepatic veinsAm. J. Surg.1835861CrossRefPubMed Smyrniotis, V, Arkadopoulos, N, Kehagias, D,  et al. 2002Liver resection with repair of major hepatic veinsAm. J. Surg.1835861CrossRefPubMed
38.
go back to reference Jones, RMcL Moulton, CE Hardy, KJ .1998Central venous pressure and its effect on blood loss during liver resectionBr. J. Surg.8510581060CrossRefPubMed Jones, RMcL Moulton, CE Hardy, KJ .1998Central venous pressure and its effect on blood loss during liver resectionBr. J. Surg.8510581060CrossRefPubMed
39.
go back to reference Melendez, JA, Arslan, V, Fischer, ME, et al. 1998Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion and the risk of postoperative renal dysfunctionJ. Am. Coll. Surg.187620625CrossRefPubMed Melendez, JA, Arslan, V, Fischer, ME,  et al. 1998Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion and the risk of postoperative renal dysfunctionJ. Am. Coll. Surg.187620625CrossRefPubMed
Metadata
Title
Selective Hepatic Vascular Exclusion versus Pringle Maneuver in Major Liver Resections: Prospective Study
Authors
Vassilios E. Smyrniotis, M.D., Ph.D.
Georgia G. Kostopanagiotou, M.D., Ph.D.
John C. Contis, M.D., Ph.D.
Charalampos I. Farantos, M.D.
Dionisios C. Voros, M.D., Ph.D.
Dimitrios C. Kannas, M.D., Ph.D.
John S. Koskinas, M.D., Ph.D.
Publication date
01-07-2003
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 7/2003
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-003-6978-8

Other articles of this Issue 7/2003

World Journal of Surgery 7/2003 Go to the issue