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International Orthopaedics

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01-11-2018 | Original Paper

Altering polymerization temperature of antibiotic-laden cement can increase porosity and subsequent antibiotic elution

Authors: Jeffrey Sundblad, Mary Nixon, Nancy Jackson, Rahul Vaidya, David Markel

Published in: International Orthopaedics | Issue 11/2018

Abstract

Purpose

To examine the role of polymerization temperature on the cement porosity and antibiotic elution to optimize antibiotic release from antibiotic-laden cement (ABLC).

Methods

Elution profiles of vancomycin and tobramycin from ABLC discs prepared with low- and high-dose antibiotic dosages, cured at 8, 21, and 37 °C, and placed in phosphate buffered saline (PBS) at 37 °C were examined. Samples were collected at one, four, eight, 24, 72, 168, 336, and 1008 hours to calculate the quantity of antibiotic eluted. Porosity was determined by MicroCT analysis.

Results

ABLC porosity and antibiotic elution were increased up to five times the amount eluted from room temperature discs (p < 0.05). Low-dose ABLC group saw decreased but similar porosity at 8 °C and 21 °C compared to cement cured at 37 °C (p < 0.001). High-dose ABLC group porosities were all significantly different (p < 0.02).

Conclusions

Altering the polymerization temperature of ABLC led to more porous constructs yielding increased antibiotic elution.

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Title: Altering polymerization temperature of antibiotic-laden cement can increase porosity and subsequent antibiotic elution
Authors: Jeffrey Sundblad
Mary Nixon
Nancy Jackson
Rahul Vaidya
David Markel
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 11/2018
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-018-4135-0

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Springer Medicine

Altering polymerization temperature of antibiotic-laden cement can increase porosity and subsequent antibiotic elution

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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