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International Orthopaedics

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01-04-2019 | Dysphagia | Review Article

Evidence-based use of arthroplasty in cervical degenerative disc disease

Authors: Andrei F. Joaquim, Melvin C. Makhni, K. Daniel Riew

Published in: International Orthopaedics | Issue 4/2019

Abstract

Introduction

Cervical disc arthroplasty (CDA) was developed to decrease the rate of symptomatic adjacent-level disease while preserving motion in the cervical spine.

Methods

The objectives of this paper are to provide criteria for proper patient selection as well as to present a comprehensive literature review of the current evidence for CDA, including randomized studies, the most recent meta-analysis findings, and long-term follow-up clinical trials as well.

Results

Currently, there are several prospective randomized controlled studies of level I of evidence attesting to the safety and efficacy of CDA in the management of cervical spondylotic disease (CSD) for one- or two-level degenerative diseases. These as well as recent meta-analyses suggest that CDA is potentially similar or even superior to anterior cervical discectomy and fusion (ACDF) when considering several outcomes, including dysphagia and re-operation rate over medium-term follow-up. Less robust studies have also reported satisfactory clinical and radiological outcomes of CDA for hybrid procedures (ACDF combined with CDA), non-contiguous disease, and even for multilevel disease (more than 2 levels).

Conclusions

Based on this evidence we conclude that CDA is a safe and effective alternative to ACDF in properly selected patients for one- or two-level diseases. Defining superiority of specific implants and detailing optimal surgical indications will require further well-designed long-term studies.

Smith GW, Robinson RA (1958) The treatment of certain cervical-spine disorders by anterior removal of the 3 intervertebral disc and interbody fusion. J Bone Joint Surg Am 40-A:607–624CrossRefPubMed

Nanda A, Sharma M, Sonig A, Ambekar S, Bollam P (2014) Surgical complications of anterior cervical diskectomy and fusion for cervical degenerative disk disease: a single surgeon’s experience of 1576 patients. World Neurosurg 82(6):1380–1387CrossRefPubMed

Jacobs W, Willems PC, Kruyt M, van Limbeek J, Pavlov P, Bartels R et al (2011) Systematic review of anterior interbody fusion techniques for single- and double-level cervical degenerative disc disease. Spine 36(14):E950–E960CrossRefPubMed

Luo J, Wang H, Peng J, Deng Z, Zhang Z, Liu S et al (2018) Rate of adjacent segment degeneration of cervical disc arthroplasty versus fusion meta-analysis of randomized controlled trials. World Neurosurg 113:225–231CrossRefPubMed

Nunley PD, Coric D, Frank KA, Stone MB (2018) Cervical disc arthroplasty: current evidence and real-world application. Neurosurgery

Mummaneni PV, Burkus JK, Haid RW, Traynelis VC, Zdeblick TA (2007) Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion: a randomized controlled clinical trial. J Neurosurg Spine 6(3):198–209CrossRefPubMed

Murrey D, Janssen M, Delamarter R et al (2009) Results of the prospective, randomized, controlled multicenter Food and Drug Administration investigational device exemption study of the ProDisc-C total disc replacement versus anterior discectomy and fusion for the treatment of 1-level symptomatic cervical disc disease. Spine J 9(4):275–286CrossRefPubMed

Heller JG, Sasso RC, Papadopoulos SM et al (2009) Comparison of BRYAN cervical disc arthroplasty with anterior cervical decompression and fusion: clinical and radiographic results of a randomized, controlled, clinical trial. Spine (Phila Pa 1976) 34(2):101–107CrossRef

Burkus JK, Haid RW, Traynelis VC, Mummaneni PV (2010) Long-term clinical and radiographic outcomes of cervical disc replacement with the Prestige disc: results from a prospective randomized controlled clinical trial. J Neurosurg Spine 13(3):308–318CrossRefPubMed

10.

Delamarter RB, Murrey D, Janssen ME et al (2010) Results at 24 months from the prospective, randomized, multicenter Investigational Device Exemption trial of ProDisc-C versus anterior cervical discectomy and fusion with 4-year follow-up and continued access patients. SAS J 4(4):122–128CrossRefPubMedPubMedCentral

11.

Coric D, Nunley PD, Guyer RD et al (2011) Prospective, randomized, multicenter study of cervical arthroplasty: 269 patients from the Kineflex|C artificial disc investigational device exemption study with a minimum 2-year follow-up: clinical article. J Neurosurg Spine 15(4):348–358CrossRefPubMed

12.

Sasso RC, Anderson PA, Riew KD, Heller JG (2011) Results of cervical arthroplasty compared with anterior discectomy and fusion: four-year clinical outcomes in a prospective, randomized controlled trial. J Bone Joint Surg Am 93-A(18):1684–1692CrossRef

13.

Phillips FM, Lee JY, Geisler FH et al (2013) A prospective, randomized, controlled clinical investigation comparing PCM cervical disc arthroplasty with anterior cervical discectomy and fusion. 2-year results from the US FDA IDE clinical trial. Spine (Phila Pa 1976) 38(15):E907–E918CrossRef

14.

Vaccaro A, Beutler W, Peppelman W et al (2013) Clinical outcomes with selectively constrained SECURE-C cervical disc arthroplasty: two-year results from a prospective, randomized, controlled, multicenter investigational device exemption study. Spine (Phila Pa 1976) 38(26):2227–2239CrossRef

15.

Zigler JE, Delamarter R, Murrey D, Spivak J, Janssen M (2013) ProDisc-C and anterior cervical discectomy and fusion as surgical treatment for singlelevel cervical symptomatic degenerative disc disease. Spine 38(3):203–209CrossRefPubMed

16.

Burkus JK, Traynelis VC, Haid RW, Mummaneni PV (2014) Clinical and radiographic analysis of an artificial cervical disc: 7-year follow-up from the Prestige prospective randomized controlled clinical trial: clinical article. J Neurosurg Spine 21(4):516–528CrossRefPubMed

17.

Hisey MS, Bae HW, Davis R, et al (2014) Multi-center, prospective, randomized, controlled investigational device exemption clinical trial comparing Mobi-C Cervical Artificial Disc to anterior discectomy and fusion in the treatment of symptomatic degenerative disc disease in the cervical spine. Int J Spine Surg 8

18.

Janssen ME, Zigler JE, Spivak JM, Delamarter RB, Darden BV, Kopjar B (2015) ProDisc-C total disc replacement versus anterior cervical discectomy and fusion for single-level symptomatic cervical disc disease. J Bone Joint Surg 97(21):1738–1747CrossRefPubMed

19.

Phillips FM, Geisler FH, Gilder KM, Reah C, Howell KM, Mcafee PC (2015) Long term outcomes of the US FDA IDE prospective, randomized controlled clinical trial comparing PCM cervical disc arthroplasty with anterior cervical discectomy and fusion. Spine 40(10):674–683CrossRefPubMed

20.

Gornet MF, Burkus JK, Shaffrey ME, Argires PJ, Nian H, Harrell FE (2015) Cervical disc arthroplasty with PRESTIGE LP disc versus anterior cervical discectomy and fusion: a prospective, multicenter investigational device exemption study. J Neurosurg Spine 23(5):558–573CrossRefPubMed

21.

Hisey MS, Bae HW, Davis RJ et al (2015) Prospective, randomized comparison of cervical total disk replacement versus anterior cervical fusion. J Spinal Disord Tech 28(4):E237–E243CrossRefPubMed

22.

Hisey M, Zigler J, Jackson R et al (2016) Prospective, randomized comparison of one-level Mobi-C cervical total disc replacement vs. anterior cervical discectomy and fusion: results at 5-year follow-up. Int J Spine Surg 10:1–9CrossRef

23.

Gornet M, Burkus JK, Shaffrey M, Nian H, Harrell F (2016) Cervical disc arthroplasty with prestige LP disc versus anterior cervical discectomy and fusion: seven-year outcomes. Int J Spine Surg 10:1–22CrossRef

24.

Janssen ME, Zigler JE, Spivak JM, Delamarter RB, Darden BV 2nd, Kopjar B (2015) ProDisc-C total disc replacement versus anterior cervical discectomy and fusion for single-level symptomatic cervical disc disease: seven-year follow-up of the prospective randomized U.S. Food and Drug Administration Investigational Device Exemption Study. J Bone Joint Surg Am 97(21):1738–1747CrossRefPubMed

25.

Ghobrial GM, Lavelle WF, Florman JE, Riew KD, Levi AD (2018) Symptomatic adjacent level disease requiring surgery: analysis of 10-year results from a prospective, randomized, clinical trial comparing cervical disc arthroplasty to anterior cervical fusion. Neurosurgery

26.

Davis RJ, Kim KD, Hisey MS et al (2013) Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. J Neurosurg Spine 19(5):532–545CrossRefPubMed

27.

Davis R, Nunley PD, Kim K et al (2014) Two-level total disc replacement with Mobi-C(r) over 3-years. Coluna/Columna 12(2):97–103CrossRef

28.

Davis RJ, Nunley PD, Kim KD et al (2015) Two-level total disc replacement with Mobi-C cervical artificial disc versus anterior discectomy and fusion: a prospective, randomized, controlled multicenter clinical trial with 4-year follow up results. J Neurosurg Spine 22(1):15–25CrossRefPubMed

29.

Radcliff K, Coric D, Albert T (2016) Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. J Neurosurg Spine 25(2):213–224CrossRefPubMed

30.

Gornet MF, Lanman TH, Burkus JK et al (2017) Cervical disc arthroplasty with the Prestige LP disc versus anterior cervical discectomy and fusion, at 2 levels: results of a prospective, multicenter randomized controlled clinical trial at 24 months. J Neurosurg Spine 26(6):653–667CrossRefPubMed

31.

Lanman TH, Burkus JK, Dryer RG, Gornet MF, McConnell J, Hodges SD (2017) Long-term clinical and radiographic outcomes of the Prestige LP artificial cervical disc replacement at 2 levels: results from a prospective randomized controlled clinical trial. J Neurosurg Spine 27(1):7–19CrossRefPubMed

32.

Lanman TH, Burkus JK, Dryer RG, Gornet MF, McConnell J, Hodges SD (2017) Long term clinical and radiographic outcomes of the Prestige LP artificial cervical discreplacement at 2 levels: results from a prospective randomized controlled clinical trial. J Neurosurg Spine 27(1):7–19CrossRefPubMed

33.

Sekhon LH, Sears W, Duggal N (2005) Cervical arthroplasty after previous surgery: results of treating 24 discs in 15 patients. J Neurosurg Spine 3:335–341CrossRefPubMed

34.

Huppert J, Beaurain J, Steib JP, Bernard P, Dufour T, Hovorka I et al (2011) Comparison between single- and multi-level patients: clinical and radiological outcomes 2 years after cervical disc replacement. Eur Spine J 20:1417–1426CrossRefPubMedPubMedCentral

35.

Kim HK, Kim MH, Cho DS, Kim SH (2009) Surgical outcome of cervical arthroplasty using Bryan®. J Korean Neurosurg Soc 46:532–537CrossRefPubMedPubMedCentral

36.

Luo J, Wang H, Peng J, Deng Z, Zhang Z, Liu S, Wang D, Gong M, Tang S (2018) Rate of adjacent segment degeneration of cervical disc arthroplasty versus fusion meta-analysis of randomized controlled trials. World Neurosurg 13:225–231CrossRef

37.

Dong L, Xu Z, Chen X, Wang D, Li D, Liu T, Hao D (2017) The change of adjacent segment after cervical disc arthroplasty compared with anterior cervical discectomy and fusion: a meta-analysis of randomized controlled trials. Spine J 17(10):1549–1558CrossRefPubMed

38.

Zhu Y, Zhang B, Liu H, Wu Y, Zhu Q (2016) Cervical disc arthroplasty versus anterior cervical discectomy and fusion for incidence of symptomatic adjacent segment disease: a meta-analysis of prospective randomized controlled trials. Spine (Phila Pa 1976) 41(19):1493–1502CrossRef

39.

Zhao H, Duan LJ, Gao YS, Yang YD, Tang XS, Zhao DY, Xiong Y, Hu ZG, Li CH, Yu X (2018) What is the superior surgical strategy for bi-level cervical spondylosis-anterior cervical disc replacement or anterior cervical decompression and fusion?: a meta-analysis from 11 studies. Medicine (Baltimore) 97(13):e0005CrossRef

40.

Rihn JA, Kane J, Albert TJ, Vaccaro AR, Hilibrand AS (2011) What is the incidence and severity of dysphagia after anterior cervical surgery? Clin Orthop Relat Res 469(3):658–665CrossRefPubMed

41.

Joaquim AF, Murar J, Savage JW, Patel AA (2014) Dysphagia after anterior cervical spine surgery: a systematic review of potential preventative measures. Spine J 14(9):2246–2260CrossRefPubMed

42.

Smucker JD, Bassuener SR, Sasso RC, Riew KD (2017) Comparison of long-term differences in dysphagia: cervical arthroplasty and anterior cervical fusion. Clin Spine Surg 30(8):E1160–E1164CrossRefPubMed

43.

Joaquim AF, Riew KD (2017) Multilevel cervical arthroplasty: current evidence. A systematic review. Neurosurg Focus 42(2):E4CrossRefPubMed

44.

Alvin MD, Mroz TE (2014) The Mobi-C cervical disc for one-level and two-level cervical disc replacement: a review of the literature. Med Devices (Auckl) 7:397–403

45.

Delamarter RB, Zigler J (2013) Five-year reoperation rates, cervical total disc replacement versus fusion, results of a prospective randomized clinical trial. Spine (Phila Pa 1976) 38(9):711–717CrossRef

46.

Blumenthal SL, Ohnmeiss DD, Guyer RD, Zigler JE (2013) Reoperations in cervical total disc replacement compared with anterior cervical fusion: results compiled from multiple prospective food and drug administration investigational device exemption trials conducted at a single site. Spine (Phila Pa 1976) 38(14):1177–1182CrossRef

47.

Jackson RJ, Davis RJ, Hoffman GA et al (2016) Subsequent surgery rates after cervical total disc replacement using a Mobi-C Cervical Disc Prosthesis versus anterior cervical discectomy and fusion: a prospective randomized clinical trial with 5-year follow-up. J Neurosurg Spine 24(5):734–745CrossRefPubMed

48.

Coric D, Guyer RD, Nunley PD et al (2018) Prospective, randomized multicenter study of cervical arthroplasty versus anterior cervical discectomy and fusion: 5-year results with a metal-on-metal artificial disc. J Neurosurg Spine 28(3):252–261CrossRefPubMed

49.

Loumeau TP, Darden BV, Kesman TJ et al (2016) A RCT comparing 7-year clinical outcomes of one level symptomatic cervical disc disease (SCDD) following ProDisc-C total disc arthroplasty (TDA) versus anterior cervical discectomy and fusion (ACDF). Eur Spine J 25(7):2263–2270CrossRefPubMed

50.

Gorrnet MF, Buttermann GR, Wohns R et al (2018) Safety and efficiency of cervical disc arthroplasty in ambulatory surgery centers vs. hospital settings. Int J Spine Surg 2(5):557–564CrossRef

51.

Fernström U (1966) Arthroplasty with intercorporal endoprothesis in herniated disc and in painful disc. Acta Chir Scand Suppl 357:154–159PubMed

52.

Hilibrand AS, Carlson GD, Palumbo MA, Jones PK, Bohlman HH (1999) Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am 81(4):519–528CrossRefPubMed

53.

Zeng J, Liu H, Chen H, et al. Effect of prosthesis width and depth on heterotopic ossification after cervical disc arthroplasty. Spine (Phila Pa 1976). 2018

54.

Zeng J, Liu H, Chen H et al (2018) Comparison of heterotopic ossification after fixed- and mobile-core cervical disc arthroplasty. World Neurosurg S1878-8750(18):32121–32121

55.

Chang PY, Chang HK, Wu JC et al (2016) Differences between C3-4 and other subaxial levels of cervical disc arthroplasty: more heterotopic ossification at the 5-year follow-up. J Neurosurg Spine 24(5):752–759CrossRefPubMed

56.

Lei T, Liu Y, Wang H et al (2016) Clinical and radiological analysis of Bryan cervical disc arthroplasty: eight-year follow-up results compared with anterior cervical discectomy and fusion. Int Orthop 40(6):1197–1203CrossRefPubMed

57.

Song Q, He D, Han X, Zhang N, Wang J, Tian W (2018) Clinical and radiological outcomes of cervical disc arthroplasty: ten year follow-up study. Int Orthop 42(10):2389–2396CrossRefPubMed

58.

Yang YC, Nie L, Cheng L, Hou Y (2009) Clinical and radiographic reports following cervical arthroplasty: a 24-month follow-up. Int Orthop 33(4):1037–1042CrossRefPubMed

59.

Cheng L, Nie L, Zhang L, Hou Y (2009) Fusion versus Bryan Cervical Disc in two-level cervical disc disease: a prospective, randomised study. Int Orthop 33(5):1347–1351CrossRefPubMed

60.

Pointillart V, Castelain JE, Coudert P, Cawley DT, Gille O, Vital JM (2018) Outcomes of the Bryan cervical disc replacement: fifteen year follow-up. Int Orthop 42(4):851–857CrossRefPubMed

Title: Evidence-based use of arthroplasty in cervical degenerative disc disease
Authors: Andrei F. Joaquim
Melvin C. Makhni
K. Daniel Riew
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keywords: Dysphagia
Dysphagia
Dysphagia
Published in: International Orthopaedics / Issue 4/2019
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-018-04281-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Evidence-based use of arthroplasty in cervical degenerative disc disease

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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