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01-08-2009 | Review

The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer

Authors: Tsukasa Seya, Misako Matsumoto

Published in: Cancer Immunology, Immunotherapy | Issue 8/2009

Abstract

Infection with RNA viruses presents a typical pattern of virus products, double-stranded RNA (dsRNA), and induces the maturation of antigen-presenting dendritic cell (mDC). There are several dsRNA sensors that are differentially distributed on the cell membrane and in the cytoplasm and are variably expressed depending on the cell type. Among these sensors, TLR3 links to the adaptor TICAM-1 (TRIF), which is characterized by its unique multipronged signaling cascades for cytokine/chemokine production, apoptosis and autophagy in both immune and tumor cells. In the context of mDC maturation, various cellular events are further induced in response to dsRNA; these include cross-priming followed by CD8+ CTL induction, NK activation and proliferation of CD4+ T cells including Th1, Th2, Treg and Th17 cells. In this review, we focus on the potential role of dsRNA in modulating the inflammatory milieu around mDCs and tumor-associated antigens to drive specific cellular effectors against the tumor.

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Title: The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer
Authors: Tsukasa Seya
Misako Matsumoto
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Cancer Immunology, Immunotherapy / Issue 8/2009
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-008-0652-9

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