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Abdominal Radiology

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Open Access 01-03-2019 | Hepatobiliary

Radiofrequency ablation following artificial ascites and pleural effusion creation may improve outcomes for hepatocellular carcinoma in high-risk locations

Authors: Yi-Chung Hsieh, Jenny L. Limquiaco, Chen-Chun Lin, Wei-Ting Chen, Shi-Ming Lin

Published in: Abdominal Radiology | Issue 3/2019

Abstract

Purpose

To investigate the outcomes of radiofrequency ablation (RFA) following artificial ascites (AA) and artificial pleural effusion (AP) creation for hepatocellular carcinoma (HCC) in high-risk locations.

Materials and methods

Eligible patients were divided into 2 study periods (non-AAAP and AAAP groups) with AAAP performed in the latter period. Local tumor progression, primary technique effectiveness and complications were compared between patients with and without AAAP. Cumulative probability of local tumor progression and overall survival were estimated with Kaplan–Meier curves.

Results

One hundred thirty-eight patients with 195 tumors were evaluated. AAAP was performed in 48 patients with 76 tumors. Local tumor progression rates at 12 and 24 months were 9.3% and 22.2% in the non-AAAP group versus 5.5% and 9% in the AAAP group (p < 0.0001). Primary technique effectiveness was achieved in 76.5% of the non-AAAP group versus 89.5% of the AAAP group (p = 0.046). Night (7.6%) major complications occurred in the non-AAAP group and 2 (2.6%) cases occurred in the AAAP group. Therapy-oriented severity grading system after RFA was lower in the AAAP group (p = 0.02). Overall survival rates at 12 and 24 months were 85.6% and 77.7% in the non-AAAP group versus 97.2% and 89.7% in the AAAP group (p = 0.033).

Conclusion

RFA following AA and AP for high-risk located HCC may improve outcomes.

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Title: Radiofrequency ablation following artificial ascites and pleural effusion creation may improve outcomes for hepatocellular carcinoma in high-risk locations
Authors: Yi-Chung Hsieh
Jenny L. Limquiaco
Chen-Chun Lin
Wei-Ting Chen
Shi-Ming Lin
Publication date: 01-03-2019
Publisher: Springer US
Published in: Abdominal Radiology / Issue 3/2019
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-018-1831-6

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