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Published in: Abdominal Radiology 7/2015

01-10-2015

Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case–control study

Authors: Xiang Fei, Wen-Ping Lu, Yu-Kun Luo, Jian-Hon Xu, Yan-Mi Li, Huai-Yin Shi, Zi-Yu Jiao, Hong-tian Li

Published in: Abdominal Radiology | Issue 7/2015

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Abstract

Purpose

The aim of this study was to find the independent risk factors related with gallbladder (GB) adenoma compared to cholesterol polyp by contrast-enhanced ultrasound (CEUS).

Materials and methods

Between January 2010 and September 2014, a total of 122 consecutive patients undergoing cholecystectomy for GB polypoid lesions were enrolled. Before cholecystectomy, each patient underwent conventional US and CEUS examination and all image features were documented. The patients were divided into adenoma group and cholesterol polyp group according to the pathological findings. All the image features between two groups were statistically compared.

Results

There were differences in patient age, lesion size, echogenicity, and vascularity of lesion between two groups (P < 0.05). There were differences in stalk width and enhancement intensity between the two groups (P < 0.05). Multiple logistic regression analysis proved that enhancement intensity, stalk of lesion, and vascularity were the independent risk factors related with GB adenoma (P < 0.05).

Conclusions

CEUS could offer useful information to distinguish adenoma from cholesterol polyp. The treatment algorithm for gallbladder polyp lesions would likely benefit from CEUS as a routine imaging investigation, especially in cases where the polyp is larger than 1 cm.
Literature
1.
go back to reference Myers RP, Shaffer EA, Beck PL (2002) Gallbladder polyps: epidemiology, natural history and management. Can J Gastroenterol 16(3):187–194PubMed Myers RP, Shaffer EA, Beck PL (2002) Gallbladder polyps: epidemiology, natural history and management. Can J Gastroenterol 16(3):187–194PubMed
2.
go back to reference Inui Kazuo, Yoshino Juniji, Miyoshi Hironao (2011) Diagnosis of gallbladder tumors. Intern Med 50(11):1133–1136CrossRefPubMed Inui Kazuo, Yoshino Juniji, Miyoshi Hironao (2011) Diagnosis of gallbladder tumors. Intern Med 50(11):1133–1136CrossRefPubMed
3.
4.
go back to reference Lee KF, Wong J, Li JC, Lai PB (2004) Polypoid lesions of the gallbladder. Am J Surg 188(2):186–190CrossRefPubMed Lee KF, Wong J, Li JC, Lai PB (2004) Polypoid lesions of the gallbladder. Am J Surg 188(2):186–190CrossRefPubMed
6.
go back to reference Sugiyama M, Xie XY, Atomi Y, et al. (1999) Differential diagnosis of small polypoid lesions of the gallbladder: the value of endoscopic ultrasonography. Ann Surg 229(4):498–504PubMedCentralCrossRefPubMed Sugiyama M, Xie XY, Atomi Y, et al. (1999) Differential diagnosis of small polypoid lesions of the gallbladder: the value of endoscopic ultrasonography. Ann Surg 229(4):498–504PubMedCentralCrossRefPubMed
7.
go back to reference Terzi C, Sokmen S, Seckin S, et al. (2000) Polypoid lesions of the gallbladder: report of 100 cases with special reference to operative indications. Surgery 127(6):622–627CrossRefPubMed Terzi C, Sokmen S, Seckin S, et al. (2000) Polypoid lesions of the gallbladder: report of 100 cases with special reference to operative indications. Surgery 127(6):622–627CrossRefPubMed
8.
go back to reference Aldridge MC, Bismuth H (1990) Gallbladder cancer: the polyp-cancer sequence. Br J Surg 77(4):363–364CrossRefPubMed Aldridge MC, Bismuth H (1990) Gallbladder cancer: the polyp-cancer sequence. Br J Surg 77(4):363–364CrossRefPubMed
9.
10.
go back to reference Kubota K, Bandai Y, Noie T, et al. (1995) How should polypoid lesions of the gallbladder be treated in the era of laparoscopic cholecystectomy? Surgery 117(5):481–487CrossRefPubMed Kubota K, Bandai Y, Noie T, et al. (1995) How should polypoid lesions of the gallbladder be treated in the era of laparoscopic cholecystectomy? Surgery 117(5):481–487CrossRefPubMed
11.
go back to reference Akyurek N, Salman B, Irkorucu O, Sare M, Tatlicioqlu E (2005) Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature. HPB 7(2):155–158PubMedCentralCrossRefPubMed Akyurek N, Salman B, Irkorucu O, Sare M, Tatlicioqlu E (2005) Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature. HPB 7(2):155–158PubMedCentralCrossRefPubMed
12.
go back to reference Azuma T, Yoshikawa T, Araida T, Takasaki K (2001) Differential diagnosis of polypoid lesions of the gallbladder by endoscopic ultrasonography. Am J Surg 181(1):65–70CrossRefPubMed Azuma T, Yoshikawa T, Araida T, Takasaki K (2001) Differential diagnosis of polypoid lesions of the gallbladder by endoscopic ultrasonography. Am J Surg 181(1):65–70CrossRefPubMed
13.
go back to reference Desautels SG, Slivka A, Hutson WR, et al. (1999) Postcholecystectomy Pain Syndrome: pathophysiology of Abdominal Pain in Sphincter of Oddi Type III. Gastroenterology 116(4):900–905CrossRefPubMed Desautels SG, Slivka A, Hutson WR, et al. (1999) Postcholecystectomy Pain Syndrome: pathophysiology of Abdominal Pain in Sphincter of Oddi Type III. Gastroenterology 116(4):900–905CrossRefPubMed
14.
go back to reference Nuzzo G, Giuliante F, Giovannini I, et al. (2005) Bile duct injury during laparoscopic cholecystectomy. Arch Surg 140(10):986–992CrossRefPubMed Nuzzo G, Giuliante F, Giovannini I, et al. (2005) Bile duct injury during laparoscopic cholecystectomy. Arch Surg 140(10):986–992CrossRefPubMed
15.
go back to reference Numata K, Morimoto M, Suqimori K, et al. (2007) Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med 26(6):763–774PubMed Numata K, Morimoto M, Suqimori K, et al. (2007) Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med 26(6):763–774PubMed
16.
go back to reference Inoue T, Kitano M, Kudo M, et al. (2007) Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography. Ultrasound Med Biol 33(3):353–361CrossRefPubMed Inoue T, Kitano M, Kudo M, et al. (2007) Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography. Ultrasound Med Biol 33(3):353–361CrossRefPubMed
17.
go back to reference Shin SR, Lee JK, Lee KH, et al. (2009) Can the growth rate of a gallbladder polyp predict a neoplastic polyp? J Clin Gastroenterol 43(9):865–868CrossRefPubMed Shin SR, Lee JK, Lee KH, et al. (2009) Can the growth rate of a gallbladder polyp predict a neoplastic polyp? J Clin Gastroenterol 43(9):865–868CrossRefPubMed
18.
go back to reference Claudon M, Cosgrove D, Albrecht T, et al. (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - update 2008. Ultraschall Med 29(1):28–44CrossRefPubMed Claudon M, Cosgrove D, Albrecht T, et al. (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - update 2008. Ultraschall Med 29(1):28–44CrossRefPubMed
19.
go back to reference Forsberg F, Merton DA, Liu JB, Needleman L, Goldberg BB (1998) Clinical applications of ultrasound contrast agents. Ultrasonics 36(1–5):695–701CrossRefPubMed Forsberg F, Merton DA, Liu JB, Needleman L, Goldberg BB (1998) Clinical applications of ultrasound contrast agents. Ultrasonics 36(1–5):695–701CrossRefPubMed
20.
go back to reference Goldberg BB, Liu JB, Frosberg F (1994) Ultrasound contrast agents: a review. Ultrasound Med Biol 20(4):319–333CrossRefPubMed Goldberg BB, Liu JB, Frosberg F (1994) Ultrasound contrast agents: a review. Ultrasound Med Biol 20(4):319–333CrossRefPubMed
21.
go back to reference Frauscher F, Pallwein L, Klauser A, et al. (2005) Ultrasound contrast agents and prostate cancer. Radiologe 45(6):544–551CrossRefPubMed Frauscher F, Pallwein L, Klauser A, et al. (2005) Ultrasound contrast agents and prostate cancer. Radiologe 45(6):544–551CrossRefPubMed
22.
go back to reference Tsuji S, Sofuni A, Moriyasu F, et al. (2012) Contrast-enhanced ultrasonography in the diagnosis of gallbladder disease. Hepatogastroenteroloyg 59(114):336–340 Tsuji S, Sofuni A, Moriyasu F, et al. (2012) Contrast-enhanced ultrasonography in the diagnosis of gallbladder disease. Hepatogastroenteroloyg 59(114):336–340
23.
go back to reference Hattori M, Inui K, Yoshino J, et al. (2007) Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions. Nihon Shokakibyo Gakkai Zasshi 104(6):790–798PubMed Hattori M, Inui K, Yoshino J, et al. (2007) Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions. Nihon Shokakibyo Gakkai Zasshi 104(6):790–798PubMed
24.
go back to reference Inoue T, Kitano M, Sakamoto H, et al. (2007) Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography. Ultrasound in Med Biol 33(3):353–361CrossRef Inoue T, Kitano M, Sakamoto H, et al. (2007) Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography. Ultrasound in Med Biol 33(3):353–361CrossRef
25.
go back to reference Xie XH, Xu HX, Xie XY, et al. (2009) Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound. Eur Radiol 20(1):239–248CrossRefPubMed Xie XH, Xu HX, Xie XY, et al. (2009) Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound. Eur Radiol 20(1):239–248CrossRefPubMed
26.
go back to reference Meacock LM, Sellars ME, Sidhu PS (2010) Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol 83(991):615–627PubMedCentralCrossRefPubMed Meacock LM, Sellars ME, Sidhu PS (2010) Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol 83(991):615–627PubMedCentralCrossRefPubMed
27.
go back to reference Corwin MT, Siewert B, Sheiman RG, Kane RA (2011) Incidentally detected gallbladder polyps: is follow-up necessary?—long-term Clinical and US Analysis of 346 Patients. Radiology 258(1):277–282CrossRefPubMed Corwin MT, Siewert B, Sheiman RG, Kane RA (2011) Incidentally detected gallbladder polyps: is follow-up necessary?—long-term Clinical and US Analysis of 346 Patients. Radiology 258(1):277–282CrossRefPubMed
28.
go back to reference Sugiyama M, Atomi Y, Kuroda A, Muto T, Wada N (1995) Large cholesterol polyps of the gallbladder: diagnosis by means of US and endoscopic US. Radiology 196(2):493–497CrossRefPubMed Sugiyama M, Atomi Y, Kuroda A, Muto T, Wada N (1995) Large cholesterol polyps of the gallbladder: diagnosis by means of US and endoscopic US. Radiology 196(2):493–497CrossRefPubMed
29.
go back to reference Numata K, Oka H, Morimoto M, et al. (2007) Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med 26(6):763–774PubMed Numata K, Oka H, Morimoto M, et al. (2007) Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med 26(6):763–774PubMed
30.
go back to reference Kwon W, Jang JY, Lee SE, Hwang DW, Kim SW (2009) Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer. J Korean Med Sci 24(3):481–487PubMedCentralCrossRefPubMed Kwon W, Jang JY, Lee SE, Hwang DW, Kim SW (2009) Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer. J Korean Med Sci 24(3):481–487PubMedCentralCrossRefPubMed
32.
go back to reference Liu LN, Xu HX, Lu MD, et al. (2012) Contrast-enhanced ultrasound in the diagnosis of gallbladder diseases: a multi-center experience. PLoS One 7(10):1–13 Liu LN, Xu HX, Lu MD, et al. (2012) Contrast-enhanced ultrasound in the diagnosis of gallbladder diseases: a multi-center experience. PLoS One 7(10):1–13
33.
go back to reference Xie XH, Xu HX, Xie XY, et al. (2010) Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound. Eur Radiol 20(1):239–248CrossRefPubMed Xie XH, Xu HX, Xie XY, et al. (2010) Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound. Eur Radiol 20(1):239–248CrossRefPubMed
Metadata
Title
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case–control study
Authors
Xiang Fei
Wen-Ping Lu
Yu-Kun Luo
Jian-Hon Xu
Yan-Mi Li
Huai-Yin Shi
Zi-Yu Jiao
Hong-tian Li
Publication date
01-10-2015
Publisher
Springer US
Published in
Abdominal Radiology / Issue 7/2015
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-015-0485-x

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