Skip to main content
Top
Published in: Abdominal Radiology 2/2015

01-02-2015

Does abdominal pain duration affect the accuracy of first-line MRI for pediatric appendicitis?

Authors: Jeffrey L. Koning, John H. Naheedy, Peter G. Kruk

Published in: Abdominal Radiology | Issue 2/2015

Login to get access

Abstract

Purpose

To compare the accuracy of first-line MRI for pediatric appendicitis between children with different durations of abdominal pain.

Materials and methods

Between November 2012 and September 2013, 364 pediatric patients underwent MRI for clinically suspected appendicitis. Patients were stratified into one group with pain lasting less than or equal to 1 day and pain longer than 1 day.

Results

In patients with early abdominal pain, appendicitis occurred in 83 of 208 patients (39.9%) vs. 49 of 156 patients with pain longer than 1 day (31.4%, p = 0.09). Sensitivity and specificity of MRI in patients with early abdominal pain were 97.6% (95% CI [91.6%–99.3%]) and 94.4% (95% CI [88.9%–97.3%]), respectively, vs. 93.9% (95% CI [83.5%–97.9%]) and 97.2% (95% CI [92.1%–99.4%]), respectively, in patients with pain longer than 1 day in duration (p = 0.36 and p = 0.35 for sensitivity and specificity, respectively).

Conclusions

First-line MRI is accurate for acute appendicitis in children presenting with early abdominal pain, and may be appropriate as the initial examination in children. Further prospective studies are needed to compare MRI vs. ultrasound as the initial examination in children with early abdominal pain to help further delineate a diagnostic imaging algorithm.
Literature
1.
go back to reference Guthery SL, Hutchings C, Dean JM, Hoff C (2004) National estimates of hospital utilization by children with gastrointestinal disorders: analysis of the 1997 kids’ inpatient database. J Pediatr 144(5):589–594PubMedCrossRef Guthery SL, Hutchings C, Dean JM, Hoff C (2004) National estimates of hospital utilization by children with gastrointestinal disorders: analysis of the 1997 kids’ inpatient database. J Pediatr 144(5):589–594PubMedCrossRef
2.
go back to reference Wagner JM, McKinney WP, Carpenter JL (1996) Does this patient have appendicitis? JAMA 276(19):1589–1594PubMedCrossRef Wagner JM, McKinney WP, Carpenter JL (1996) Does this patient have appendicitis? JAMA 276(19):1589–1594PubMedCrossRef
3.
go back to reference Dixon JM, Elton RA, Rainey JB, Macleod DA (1991) Rectal examination in patients with pain in the right lower quadrant of the abdomen. BMJ 302(6773):386–388PubMedCentralPubMedCrossRef Dixon JM, Elton RA, Rainey JB, Macleod DA (1991) Rectal examination in patients with pain in the right lower quadrant of the abdomen. BMJ 302(6773):386–388PubMedCentralPubMedCrossRef
4.
go back to reference Maxwell JM, Ragland JJ (1991) Appendicitis. Improvements in diagnosis and treatment. Am Surg 57(5):282–285PubMed Maxwell JM, Ragland JJ (1991) Appendicitis. Improvements in diagnosis and treatment. Am Surg 57(5):282–285PubMed
5.
go back to reference Hardin DM Jr (1999) Acute appendicitis: review and update. Am Fam Physician 60(7):2027–2034PubMed Hardin DM Jr (1999) Acute appendicitis: review and update. Am Fam Physician 60(7):2027–2034PubMed
6.
go back to reference Brender JD, Marcuse EK, Koepsell TD, Hatch EI (1985) Childhood appendicitis: factors associated with perforation. Pediatrics 76(2):301–306PubMed Brender JD, Marcuse EK, Koepsell TD, Hatch EI (1985) Childhood appendicitis: factors associated with perforation. Pediatrics 76(2):301–306PubMed
7.
go back to reference Stone HH, Sanders SL, Martin JD Jr (1971) Perforated appendicitis in children. Surgery 69(5):673–679PubMed Stone HH, Sanders SL, Martin JD Jr (1971) Perforated appendicitis in children. Surgery 69(5):673–679PubMed
8.
go back to reference Graham JM, Pokorny WJ, Harberg FJ (1980) Acute appendicitis in preschool age children. Am J Surg 139(2):247–250PubMedCrossRef Graham JM, Pokorny WJ, Harberg FJ (1980) Acute appendicitis in preschool age children. Am J Surg 139(2):247–250PubMedCrossRef
9.
go back to reference Scher KS, Coil JA Jr (1980) Appendicitis: factors that influence the frequency of perforation. South Med J 73(12):1561–1563PubMedCrossRef Scher KS, Coil JA Jr (1980) Appendicitis: factors that influence the frequency of perforation. South Med J 73(12):1561–1563PubMedCrossRef
10.
go back to reference Eldar S, Nash E, Sabo E, et al. (1997) Delay of surgery in acute appendicitis. Am J Surg 173(3):194–198PubMedCrossRef Eldar S, Nash E, Sabo E, et al. (1997) Delay of surgery in acute appendicitis. Am J Surg 173(3):194–198PubMedCrossRef
11.
go back to reference Graff L, Russell J, Seashore J, et al. (2000) False-negative and false-positive errors in abdominal pain evaluation: failure to diagnose acute appendicitis and unnecessary surgery. Acad Emerg Med 7(11):1244–1255PubMedCrossRef Graff L, Russell J, Seashore J, et al. (2000) False-negative and false-positive errors in abdominal pain evaluation: failure to diagnose acute appendicitis and unnecessary surgery. Acad Emerg Med 7(11):1244–1255PubMedCrossRef
12.
go back to reference Saito JM, Yan Y, Evashwick TW, Warner BW, Tarr PI (2013) Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis. Pediatrics 131(1):e37–e44PubMedCentralPubMedCrossRef Saito JM, Yan Y, Evashwick TW, Warner BW, Tarr PI (2013) Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis. Pediatrics 131(1):e37–e44PubMedCentralPubMedCrossRef
13.
go back to reference Raval MV, Deans KJ, Rangel SJ, Kelleher KJ, Moss RL (2012) Factors associated with imaging modality choice in children with appendicitis. J Surg Res 177(1):131–136PubMedCrossRef Raval MV, Deans KJ, Rangel SJ, Kelleher KJ, Moss RL (2012) Factors associated with imaging modality choice in children with appendicitis. J Surg Res 177(1):131–136PubMedCrossRef
14.
go back to reference Aspelund G, Fingeret A, Gross E, et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133(4):586–593PubMedCrossRef Aspelund G, Fingeret A, Gross E, et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133(4):586–593PubMedCrossRef
15.
go back to reference Hernanz-Schulman M (2010) CT and US in the diagnosis of appendicitis: an argument for CT. Radiology 255(1):3–7PubMedCrossRef Hernanz-Schulman M (2010) CT and US in the diagnosis of appendicitis: an argument for CT. Radiology 255(1):3–7PubMedCrossRef
16.
go back to reference Bachur RG, Dayan PS, Bajaj L, et al. (2012) The effect of abdominal pain duration on the accuracy of diagnostic imaging for pediatric appendicitis. Ann Emerg Med 60(5):582–90.e3. Bachur RG, Dayan PS, Bajaj L, et al. (2012) The effect of abdominal pain duration on the accuracy of diagnostic imaging for pediatric appendicitis. Ann Emerg Med 60(5):582–90.e3.
17.
go back to reference Herliczek TW, Swenson DW, Mayo-Smith WW (2013) Utility of MRI after inconclusive ultrasound in pediatric patients with suspected appendicitis: retrospective review of 60 consecutive patients. AJR Am J Roentgenol 200(5):969–973PubMedCrossRef Herliczek TW, Swenson DW, Mayo-Smith WW (2013) Utility of MRI after inconclusive ultrasound in pediatric patients with suspected appendicitis: retrospective review of 60 consecutive patients. AJR Am J Roentgenol 200(5):969–973PubMedCrossRef
18.
go back to reference Moore MM, Gustas CN, Choudhary AK, et al. (2012) MRI for clinically suspected pediatric appendicitis: an implemented program. Pediatr Radiol 42(9):1056–1063PubMedCrossRef Moore MM, Gustas CN, Choudhary AK, et al. (2012) MRI for clinically suspected pediatric appendicitis: an implemented program. Pediatr Radiol 42(9):1056–1063PubMedCrossRef
19.
go back to reference Johnson AK, Filippi CG, Andrews T, et al. (2012) Ultrafast 3-T MRI in the evaluation of children with acute lower abdominal pain for the detection of appendicitis. AJR Am J Roentgenol 198(6):1424–1430PubMedCrossRef Johnson AK, Filippi CG, Andrews T, et al. (2012) Ultrafast 3-T MRI in the evaluation of children with acute lower abdominal pain for the detection of appendicitis. AJR Am J Roentgenol 198(6):1424–1430PubMedCrossRef
20.
go back to reference Cobben L, Groot I, Kingma L, et al. (2009) A simple MRI protocol in patients with clinically suspected appendicitis: results in 138 patients and effect on outcome of appendectomy. Eur Radiol 19(5):1175–1183PubMedCrossRef Cobben L, Groot I, Kingma L, et al. (2009) A simple MRI protocol in patients with clinically suspected appendicitis: results in 138 patients and effect on outcome of appendectomy. Eur Radiol 19(5):1175–1183PubMedCrossRef
21.
go back to reference Hormann M, Paya K, Eibenberger K, et al. (1998) MR imaging in children with nonperforated acute appendicitis: value of unenhanced MR imaging in sonographically selected cases. AJR Am J Roentgenol 171(2):467–470PubMedCrossRef Hormann M, Paya K, Eibenberger K, et al. (1998) MR imaging in children with nonperforated acute appendicitis: value of unenhanced MR imaging in sonographically selected cases. AJR Am J Roentgenol 171(2):467–470PubMedCrossRef
22.
go back to reference Bayraktutan U, Oral A, Kantarci M, et al. (2013) Diagnostic performance of diffusion-weighted MR imaging in detecting acute appendicitis in children: comparison with conventional MRI and surgical findings. J Magn Reson Imaging. 39:1518–1524 Bayraktutan U, Oral A, Kantarci M, et al. (2013) Diagnostic performance of diffusion-weighted MR imaging in detecting acute appendicitis in children: comparison with conventional MRI and surgical findings. J Magn Reson Imaging. 39:1518–1524
23.
go back to reference Koning JL, Naheedy JH, Kruk PG (2014) Diagnostic performance of contrast-enhanced MR for acute appendicitis and alternative causes of abdominal pain in children. Pediatr Radiol 44(8):948–955PubMedCrossRef Koning JL, Naheedy JH, Kruk PG (2014) Diagnostic performance of contrast-enhanced MR for acute appendicitis and alternative causes of abdominal pain in children. Pediatr Radiol 44(8):948–955PubMedCrossRef
24.
go back to reference Orth RC, Guillerman RP, Zhang W, Masand P, Bisset GS 3rd (2014) Prospective comparison of MR imaging and US for the diagnosis of pediatric appendicitis. Radiology 17:132206 Orth RC, Guillerman RP, Zhang W, Masand P, Bisset GS 3rd (2014) Prospective comparison of MR imaging and US for the diagnosis of pediatric appendicitis. Radiology 17:132206
25.
go back to reference Aspelund G, Fingeret A, Gross E, et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133(4):586–593PubMedCrossRef Aspelund G, Fingeret A, Gross E, et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133(4):586–593PubMedCrossRef
26.
go back to reference Incesu L, Coskun A, Selcuk MB, et al. (1997) Acute appendicitis: MR imaging and sonographic correlation. AJR Am J Roentgenol 168(3):669–674PubMedCrossRef Incesu L, Coskun A, Selcuk MB, et al. (1997) Acute appendicitis: MR imaging and sonographic correlation. AJR Am J Roentgenol 168(3):669–674PubMedCrossRef
27.
go back to reference Nikolaidis P, Hwang CM, Miller FH, Papanicolaou N (2004) The nonvisualized appendix: incidence of acute appendicitis when secondary inflammatory changes are absent. AJR Am J Roentgenol 183(4):889–892PubMedCrossRef Nikolaidis P, Hwang CM, Miller FH, Papanicolaou N (2004) The nonvisualized appendix: incidence of acute appendicitis when secondary inflammatory changes are absent. AJR Am J Roentgenol 183(4):889–892PubMedCrossRef
28.
go back to reference Trout AT, Towbin AJ, Zhang B (2014) Journal club: the pediatric appendix: defining normal. AJR Am J Roentgenol 202(5):936–945PubMedCrossRef Trout AT, Towbin AJ, Zhang B (2014) Journal club: the pediatric appendix: defining normal. AJR Am J Roentgenol 202(5):936–945PubMedCrossRef
29.
go back to reference Luckmann R, Davis P (1991) The epidemiology of acute appendicitis in California: racial, gender, and seasonal variation. Epidemiology 2(5):323–330PubMedCrossRef Luckmann R, Davis P (1991) The epidemiology of acute appendicitis in California: racial, gender, and seasonal variation. Epidemiology 2(5):323–330PubMedCrossRef
Metadata
Title
Does abdominal pain duration affect the accuracy of first-line MRI for pediatric appendicitis?
Authors
Jeffrey L. Koning
John H. Naheedy
Peter G. Kruk
Publication date
01-02-2015
Publisher
Springer US
Published in
Abdominal Radiology / Issue 2/2015
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-014-0223-9

Other articles of this Issue 2/2015

Abdominal Radiology 2/2015 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.