Skip to main content
Top
Published in: Abdominal Radiology 1/2013

Open Access 01-02-2013

Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease

Authors: Stijn J. B. Van Weyenberg, Koen Bouman, Maarten A. J. M. Jacobs, Brendan P. Halloran, Donald L. Van der Peet, Chris J. J. Mulder, Cornelis Van Kuijk, Jan Hein T. M. Van Waesberghe

Published in: Abdominal Radiology | Issue 1/2013

Login to get access

Abstract

Purpose

To evaluate the diagnostic accuracy of MR enteroclysis and to compare it to video capsule endoscopy (VCE) in the analysis of suspected small-bowel disease.

Methods

We performed a retrospective analysis of 77 patients who underwent both MR enteroclysis and VCE and compared the findings of these studies with the findings of enteroscopy, surgery, or with the results of clinical follow-up lasting ≥2 years.

Results

Findings included malignant neoplasms (n = 13), benign neoplasms (n = 10), refractory celiac disease (n = 4), Crohn’s disease (n = 2) and miscellaneous conditions (n = 10). Specificity of MR enteroclysis was higher than that of VCE (0.97 vs. 0.84, P = 0.047), whereas sensitivity was similar (0.79 vs. 0.74, P = 0.591). In 2/32 (6.3%) patients with both negative VCE and negative MR enteroclysis a positive diagnosis was established, compared to 5/11 (45.5%) patients in whom VCE was positive and MR enteroclysis was negative (likelihood ratio 8.1; P = 0.004), 9/11 (81.8%) patients in whom MR enteroclysis was positive and VCE was negative (likelihood ratio 23.5; P < 0.0001), and all 23 patients in whom both VCE and MR enteroclysis showed abnormalities (likelihood ratio 60.8; P < 0.0001).

Conclusions

VCE and MR enteroclysis are complementary modalities. In our study-population, MR enteroclysis was more specific than VCE, while both produced the same sensitivity.
Literature
1.
go back to reference Swaminath A, Legnani P, Kornbluth A (2010) Video capsule endoscopy in inflammatory bowel disease: past, present, and future redux. Inflamm Bowel Dis 16:1254–1262PubMedCrossRef Swaminath A, Legnani P, Kornbluth A (2010) Video capsule endoscopy in inflammatory bowel disease: past, present, and future redux. Inflamm Bowel Dis 16:1254–1262PubMedCrossRef
2.
go back to reference Horsthuis K, Bipat S, Stokkers PC, Stoker J (2009) Magnetic resonance imaging for evaluation of disease activity in Crohn’s disease: a systematic review. Eur Radiol 19:1450–1460PubMedCrossRef Horsthuis K, Bipat S, Stokkers PC, Stoker J (2009) Magnetic resonance imaging for evaluation of disease activity in Crohn’s disease: a systematic review. Eur Radiol 19:1450–1460PubMedCrossRef
3.
go back to reference Fisher L, Lee Krinsky M, Anderson MA, et al. (2010) The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc 72:471–479PubMedCrossRef Fisher L, Lee Krinsky M, Anderson MA, et al. (2010) The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc 72:471–479PubMedCrossRef
4.
go back to reference Buckley O, Brien JO, Ward E, et al. (2008) The imaging of coeliac disease and its complications. Eur J Radiol 65:483–490PubMedCrossRef Buckley O, Brien JO, Ward E, et al. (2008) The imaging of coeliac disease and its complications. Eur J Radiol 65:483–490PubMedCrossRef
5.
go back to reference Rondonotti E, Villa F, Saladino V, de Franchis R (2009) Enteroscopy in the diagnosis and management of celiac disease. Gastrointest Endosc Clin N Am 19:445–460PubMedCrossRef Rondonotti E, Villa F, Saladino V, de Franchis R (2009) Enteroscopy in the diagnosis and management of celiac disease. Gastrointest Endosc Clin N Am 19:445–460PubMedCrossRef
6.
go back to reference Soyer P, Boudiaf M, Fishman EK, et al. (2011) Imaging of malignant neoplasms of the mesenteric small bowel: new trends and perspectives. Crit Rev Oncol Hematol 80:10–30PubMedCrossRef Soyer P, Boudiaf M, Fishman EK, et al. (2011) Imaging of malignant neoplasms of the mesenteric small bowel: new trends and perspectives. Crit Rev Oncol Hematol 80:10–30PubMedCrossRef
7.
go back to reference Graca BM, Freire PA, Brito JB, et al. (2010) Gastroenterologic and radiologic approach to obscure gastrointestinal bleeding: how, why, and when? Radiographics 30:235–252PubMedCrossRef Graca BM, Freire PA, Brito JB, et al. (2010) Gastroenterologic and radiologic approach to obscure gastrointestinal bleeding: how, why, and when? Radiographics 30:235–252PubMedCrossRef
8.
go back to reference Van Weyenberg SJ, Van Waesberghe JH, Ell C, Pohl J (2009) Enteroscopy and its relationship to radiological small bowel imaging. Gastrointest Endosc Clin N Am 19:389–407PubMedCrossRef Van Weyenberg SJ, Van Waesberghe JH, Ell C, Pohl J (2009) Enteroscopy and its relationship to radiological small bowel imaging. Gastrointest Endosc Clin N Am 19:389–407PubMedCrossRef
9.
go back to reference Leighton JA (2011) The role of endoscopic imaging of the small bowel in clinical practice. Am J Gastroenterol 106:27–36 (quiz 37)PubMedCrossRef Leighton JA (2011) The role of endoscopic imaging of the small bowel in clinical practice. Am J Gastroenterol 106:27–36 (quiz 37)PubMedCrossRef
10.
11.
go back to reference Akerman PA, Cantero D (2009) Spiral enteroscopy and push enteroscopy. Gastrointest Endosc Clin N Am 19:357–369PubMedCrossRef Akerman PA, Cantero D (2009) Spiral enteroscopy and push enteroscopy. Gastrointest Endosc Clin N Am 19:357–369PubMedCrossRef
12.
go back to reference May A (2009) Balloon enteroscopy: single- and double-balloon enteroscopy. Gastrointest Endosc Clin N Am 19:349–356PubMedCrossRef May A (2009) Balloon enteroscopy: single- and double-balloon enteroscopy. Gastrointest Endosc Clin N Am 19:349–356PubMedCrossRef
13.
go back to reference Dionisio PM, Gurudu SR, Leighton JA, et al. (2010) Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol 105:1240–1248 (quiz 1249)PubMedCrossRef Dionisio PM, Gurudu SR, Leighton JA, et al. (2010) Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol 105:1240–1248 (quiz 1249)PubMedCrossRef
14.
go back to reference Khalife S, Soyer P, Alatawi A, et al. (2010) Obscure gastrointestinal bleeding: preliminary comparison of 64-section CT enteroclysis with video capsule endoscopy. Eur Radiol 21:79–86PubMedCrossRef Khalife S, Soyer P, Alatawi A, et al. (2010) Obscure gastrointestinal bleeding: preliminary comparison of 64-section CT enteroclysis with video capsule endoscopy. Eur Radiol 21:79–86PubMedCrossRef
15.
go back to reference Laine L, Sahota A, Shah A (2010) Does capsule endoscopy improve outcomes in obscure gastrointestinal bleeding? Randomized trial versus dedicated small bowel radiography. Gastroenterology 138:1673–1680 (e1671; quiz e1611–1672)PubMedCrossRef Laine L, Sahota A, Shah A (2010) Does capsule endoscopy improve outcomes in obscure gastrointestinal bleeding? Randomized trial versus dedicated small bowel radiography. Gastroenterology 138:1673–1680 (e1671; quiz e1611–1672)PubMedCrossRef
16.
go back to reference Nutter M, Dunston D, Ieyoub J, et al. (2010) A retrospective analysis comparing small bowel follow-through with wireless capsule endoscopy in the evaluation of obscure gastrointestinal bleeding. Gastroenterol Nurs 33:298–302PubMedCrossRef Nutter M, Dunston D, Ieyoub J, et al. (2010) A retrospective analysis comparing small bowel follow-through with wireless capsule endoscopy in the evaluation of obscure gastrointestinal bleeding. Gastroenterol Nurs 33:298–302PubMedCrossRef
17.
go back to reference Postgate A, Hyer W, Phillips R, et al. (2009) Feasibility of video capsule endoscopy in the management of children with Peutz–Jeghers syndrome: a blinded comparison with barium enterography for the detection of small bowel polyps. J Pediatr Gastroenterol Nutr 49:417–423PubMedCrossRef Postgate A, Hyer W, Phillips R, et al. (2009) Feasibility of video capsule endoscopy in the management of children with Peutz–Jeghers syndrome: a blinded comparison with barium enterography for the detection of small bowel polyps. J Pediatr Gastroenterol Nutr 49:417–423PubMedCrossRef
18.
go back to reference Bocker U, Dinter D, Litterer C, et al. (2010) Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield. Scand J Gastroenterol 45:490–500PubMedCrossRef Bocker U, Dinter D, Litterer C, et al. (2010) Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield. Scand J Gastroenterol 45:490–500PubMedCrossRef
19.
go back to reference Crook DW, Knuesel PR, Froehlich JM, et al. (2009) Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease. Eur J Gastroenterol Hepatol 21:54–65PubMedCrossRef Crook DW, Knuesel PR, Froehlich JM, et al. (2009) Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease. Eur J Gastroenterol Hepatol 21:54–65PubMedCrossRef
20.
go back to reference Van Weyenberg SJ, Meijerink MR, Jacobs MA, et al. (2011) MR enteroclysis in refractory celiac disease: proposal and validation of a severity scoring system. Radiology 259:151–161PubMedCrossRef Van Weyenberg SJ, Meijerink MR, Jacobs MA, et al. (2011) MR enteroclysis in refractory celiac disease: proposal and validation of a severity scoring system. Radiology 259:151–161PubMedCrossRef
21.
go back to reference Van Weyenberg SJ, Meijerink MR, Jacobs MA, et al. (2010) MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology 254:765–773PubMedCrossRef Van Weyenberg SJ, Meijerink MR, Jacobs MA, et al. (2010) MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology 254:765–773PubMedCrossRef
22.
go back to reference Masselli G, Polettini E, Casciani E, et al. (2009) Small-bowel neoplasms: prospective evaluation of MR enteroclysis. Radiology 251:743–750PubMedCrossRef Masselli G, Polettini E, Casciani E, et al. (2009) Small-bowel neoplasms: prospective evaluation of MR enteroclysis. Radiology 251:743–750PubMedCrossRef
23.
go back to reference Yamamoto H, Sekine Y, Sato Y, et al. (2001) Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc 53:216–220PubMedCrossRef Yamamoto H, Sekine Y, Sato Y, et al. (2001) Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc 53:216–220PubMedCrossRef
24.
go back to reference Nakamura M, Ohmiya N, Shirai O, et al. (2010) Route selection for double-balloon endoscopy, based on capsule transit time, in obscure gastrointestinal bleeding. J Gastroenterol 45:592–599PubMedCrossRef Nakamura M, Ohmiya N, Shirai O, et al. (2010) Route selection for double-balloon endoscopy, based on capsule transit time, in obscure gastrointestinal bleeding. J Gastroenterol 45:592–599PubMedCrossRef
25.
go back to reference Postgate A, Despott E, Burling D, et al. (2008) Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy. Gastrointest Endosc 68:1209–1214PubMedCrossRef Postgate A, Despott E, Burling D, et al. (2008) Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy. Gastrointest Endosc 68:1209–1214PubMedCrossRef
26.
go back to reference Lee MM, Jacques A, Lam E, et al. (2010) Factors associated with incomplete small bowel capsule endoscopy studies. World J Gastroenterol 16:5329–5333PubMedCrossRef Lee MM, Jacques A, Lam E, et al. (2010) Factors associated with incomplete small bowel capsule endoscopy studies. World J Gastroenterol 16:5329–5333PubMedCrossRef
27.
go back to reference Westerhof J, Weersma RK, Koornstra JJ (2009) Risk factors for incomplete small-bowel capsule endoscopy. Gastrointest Endosc 69:74–80PubMedCrossRef Westerhof J, Weersma RK, Koornstra JJ (2009) Risk factors for incomplete small-bowel capsule endoscopy. Gastrointest Endosc 69:74–80PubMedCrossRef
28.
go back to reference Van Weyenberg SJ, Van Turenhout ST, Bouma G, et al. (2010) Double-balloon endoscopy as the primary method for small-bowel video capsule endoscope retrieval. Gastrointest Endosc 71:535–541PubMedCrossRef Van Weyenberg SJ, Van Turenhout ST, Bouma G, et al. (2010) Double-balloon endoscopy as the primary method for small-bowel video capsule endoscope retrieval. Gastrointest Endosc 71:535–541PubMedCrossRef
29.
go back to reference Roorda AK, Kupec JT, Ostrinsky Y, et al. (2010) Endoscopic approach to capsule endoscope retention. Expert Rev Gastroenterol Hepatol 4:713–721PubMedCrossRef Roorda AK, Kupec JT, Ostrinsky Y, et al. (2010) Endoscopic approach to capsule endoscope retention. Expert Rev Gastroenterol Hepatol 4:713–721PubMedCrossRef
30.
go back to reference Voderholzer WA, Ortner M, Rogalla P, Beinholzl J, Lochs H (2003) Diagnostic yield of wireless capsule enteroscopy in comparison with computed tomography enteroclysis. Endoscopy 35:1009–1014PubMedCrossRef Voderholzer WA, Ortner M, Rogalla P, Beinholzl J, Lochs H (2003) Diagnostic yield of wireless capsule enteroscopy in comparison with computed tomography enteroclysis. Endoscopy 35:1009–1014PubMedCrossRef
31.
go back to reference Triester SL, Leighton JA, Leontiadis GI, et al. (2006) A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol 101:954–964PubMedCrossRef Triester SL, Leighton JA, Leontiadis GI, et al. (2006) A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol 101:954–964PubMedCrossRef
32.
go back to reference Solem CA, Loftus EV Jr, Fletcher JG, et al. (2008) Small-bowel imaging in Crohn’s disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc 68:255–266PubMedCrossRef Solem CA, Loftus EV Jr, Fletcher JG, et al. (2008) Small-bowel imaging in Crohn’s disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc 68:255–266PubMedCrossRef
33.
go back to reference Hara AK, Leighton JA, Heigh RI, et al. (2006) Crohn disease of the small bowel: preliminary comparison among CT enterography, capsule endoscopy, small-bowel follow-through, and ileoscopy. Radiology 238:128–134PubMedCrossRef Hara AK, Leighton JA, Heigh RI, et al. (2006) Crohn disease of the small bowel: preliminary comparison among CT enterography, capsule endoscopy, small-bowel follow-through, and ileoscopy. Radiology 238:128–134PubMedCrossRef
34.
go back to reference Eliakim R, Suissa A, Yassin K, Katz D, Fischer D (2004) Wireless capsule video endoscopy compared to barium follow-through and computerised tomography in patients with suspected Crohn’s disease—final report. Dig Liver Dis 36:519–522PubMedCrossRef Eliakim R, Suissa A, Yassin K, Katz D, Fischer D (2004) Wireless capsule video endoscopy compared to barium follow-through and computerised tomography in patients with suspected Crohn’s disease—final report. Dig Liver Dis 36:519–522PubMedCrossRef
35.
go back to reference Eliakim R, Fischer D, Suissa A, et al. (2003) Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol 15:363–367PubMedCrossRef Eliakim R, Fischer D, Suissa A, et al. (2003) Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol 15:363–367PubMedCrossRef
36.
go back to reference Dubcenco E, Jeejeebhoy KN, Petroniene R, et al. (2005) Capsule endoscopy findings in patients with established and suspected small-bowel Crohn’s disease: correlation with radiologic, endoscopic, and histologic findings. Gastrointest Endosc 62:538–544PubMedCrossRef Dubcenco E, Jeejeebhoy KN, Petroniene R, et al. (2005) Capsule endoscopy findings in patients with established and suspected small-bowel Crohn’s disease: correlation with radiologic, endoscopic, and histologic findings. Gastrointest Endosc 62:538–544PubMedCrossRef
37.
go back to reference Costamagna G, Shah SK, Riccioni ME, et al. (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:999–1005PubMedCrossRef Costamagna G, Shah SK, Riccioni ME, et al. (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:999–1005PubMedCrossRef
38.
go back to reference Albert JG, Martiny F, Krummenerl A, et al. (2005) Diagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis. Gut 54:1721–1727PubMedCrossRef Albert JG, Martiny F, Krummenerl A, et al. (2005) Diagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis. Gut 54:1721–1727PubMedCrossRef
39.
go back to reference Rajesh A, Sandrasegaran K, Jennings SG, et al. (2009) Comparison of capsule endoscopy with enteroclysis in the investigation of small bowel disease. Abdom Imaging 34:459–466PubMedCrossRef Rajesh A, Sandrasegaran K, Jennings SG, et al. (2009) Comparison of capsule endoscopy with enteroclysis in the investigation of small bowel disease. Abdom Imaging 34:459–466PubMedCrossRef
40.
go back to reference van Turenhout ST, Jacobs MA, van Weyenberg SJ, et al. (2010) Diagnostic yield of capsule endoscopy in a tertiary hospital in patients with obscure gastrointestinal bleeding. J Gastrointestin Liver Dis 19:141–145PubMed van Turenhout ST, Jacobs MA, van Weyenberg SJ, et al. (2010) Diagnostic yield of capsule endoscopy in a tertiary hospital in patients with obscure gastrointestinal bleeding. J Gastrointestin Liver Dis 19:141–145PubMed
41.
go back to reference Maglinte DD, Sandrasegaran K, Chiorean M, et al. (2007) Radiologic investigations complement and add diagnostic information to capsule endoscopy of small-bowel diseases. AJR Am J Roentgenol 189:306–312PubMedCrossRef Maglinte DD, Sandrasegaran K, Chiorean M, et al. (2007) Radiologic investigations complement and add diagnostic information to capsule endoscopy of small-bowel diseases. AJR Am J Roentgenol 189:306–312PubMedCrossRef
Metadata
Title
Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease
Authors
Stijn J. B. Van Weyenberg
Koen Bouman
Maarten A. J. M. Jacobs
Brendan P. Halloran
Donald L. Van der Peet
Chris J. J. Mulder
Cornelis Van Kuijk
Jan Hein T. M. Van Waesberghe
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Abdominal Radiology / Issue 1/2013
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-012-9892-4

Other articles of this Issue 1/2013

Abdominal Radiology 1/2013 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.