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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-06-2020 | Glioblastoma | Image of the Month

Tumor uptake in glioblastoma multiforme after IV injection of [¹⁷⁷Lu]Lu-PSMA-617

Authors: Jolanta Kunikowska, Ingeborga Charzyńska, Radosław Kuliński, Dariusz Pawlak, Michał Maurin, Leszek Królicki

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2020

Excerpt

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with limited treatment options in case of recurrence. Prostate-specific membrane antigen (PSMA) expression was demonstrated in microvascular endothelium of GBM and in vivo confirmed by [⁶⁸Ga]Ga-PSMA-11 PET/CT in primary as well in recurrence tumor [1‐4]. This knowledge opens a new way for targeted, PSMA-based treatment. However, it was suggested that uptake not in tumor cells, but in microvascular endothelium, could be characterized by quick washout. …

Wernicke AG, Edgar MA, Lavi E, et al. Prostate-specific membrane antigen as a potential novel vascular target for treatment of glioblastoma multiforme. Arch Pathol Lab Med. 2011;135:1486–9.CrossRef

Marafi F, Sasikumar A, Fathallah W, Esmail A. 18F-PSMA 1007 Brain PET/CT imaging in glioma recurrence. Clin Nucl Med. 2020;45:e61–2. https://doi.org/10.1097/RLU.0000000000002668.CrossRefPubMed

Kunikowska J, Królicki B, Królicki L. Glioblastoma multiforme: another potential application for ⁶⁸Ga-PSMA PET/CT as a guide for targeted therapy. Eur J Nucl Med Mol Imaging. 2018;45:886–7. https://doi.org/10.1007/s00259-018-3934-2.CrossRefPubMed

Kunikowska J, Kuliński R, Muylle K, Koziara H. Królicki L ⁶⁸Ga PSMA-11 PET/CT: a new imaging option for recurrent glioblastoma multiforme? Clin Nucl Med. 2020;45:11–8. https://doi.org/10.1097/RLU.0000000000002806.CrossRefPubMed

Giammarile F, Muylle K, Delgado Bolton R, Kunikowska J, Haberkorn U, Oyen W. Dosimetry in clinical radionuclide therapy: the devil is in the detail. Eur J Nucl Med Mol Imaging. 2017;44:2137–9. https://doi.org/10.1007/s00259-017-3820-3 Erratum in: Eur J Nucl Med Mol Imaging. 2018;45:676. doi: 10.1007/s00259-017-3921-z.CrossRefPubMed

Title: Tumor uptake in glioblastoma multiforme after IV injection of [177Lu]Lu-PSMA-617
Authors: Jolanta Kunikowska
Ingeborga Charzyńska
Radosław Kuliński
Dariusz Pawlak
Michał Maurin
Leszek Królicki
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Glioblastoma
Glioblastoma
Glioblastoma
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2020
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-020-04715-z

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Tumor uptake in glioblastoma multiforme after IV injection of [¹⁷⁷Lu]Lu-PSMA-617

Excerpt

Keynote webinar | Spotlight on sleep in brain health

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