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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2020 | Prostate Cancer | Original Article

Digital versus analogue PET in [⁶⁸Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison

Authors: Ian Alberts, George Prenosil, Christos Sachpekidis, Thilo Weitzel, Kuangyu Shi, Axel Rominger, Ali Afshar-Oromieh

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2020

Abstract

Purpose

Digital PET/CT scanners represent a significant step forward in molecular imaging. We report here the clinical impact of digital PET in PSMA-PET/CT.

Methods

In this retrospective study, 88 consecutive patients who underwent [⁶⁸Ga]Ga-PSMA-11 PET/CT on a digital PET/CT (dPET/CT) scanner for recurrent prostate cancer (PC) were included in a first cohort. In a second step, 88 individuals who underwent an analogue [⁶⁸Ga]Ga-PSMA-11 PET/CT (aPET/CT) were selected after they were matched to the first cohort for clinical parameters. Following consensus read by two nuclear medicine physicians, the number and type of PC lesions as well as benign, PSMA-positive lesions were recorded. The results were complemented by extensive [⁶⁸Ga]Ga phantom measurements to determine imaging characteristics of both scanners.

Results

dPET/CT revealed a greater number of PC lesions compared to aPET/CT (326 versus 142) as well as a proportional increase in benign causes of tracer-uptake (144 versus 65). A greater number of scans were noted as pathological for PC on dPET/CT (74/88) compared to aPET/CT (64/88, p < 0.05). The PSMA positivity rate for PC was significantly higher in dPET/CT for the lowest PSA values (PSA < 2.0 ng/ml, p < 0.05).

Conclusion

dPET/CT detected more PC lesions compared to aPET/CT. A significantly higher rate of pathological PET/CTs was noted in the group with the lowest PSA values. A higher number of benign PSMA-positive lesions were also noted in dPET/CT. The differences could be plausibly explained by the measured imaging characteristics of the scanners.

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Title: Digital versus analogue PET in [68Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison
Authors: Ian Alberts
George Prenosil
Christos Sachpekidis
Thilo Weitzel
Kuangyu Shi
Axel Rominger
Ali Afshar-Oromieh
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Prostate Cancer
Prostate Cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2020
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04630-y

ACC 2024 Congress

Springer Medicine

Digital versus analogue PET in [⁶⁸Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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