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European Journal of Nuclear Medicine and Molecular Imaging

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01-07-2019 | Lung Cancer | Image of the Month

FAPI-PET/CT improves staging in a lung cancer patient with cerebral metastasis

Authors: Frederik L. Giesel, Claus Peter Heussel, Thomas Lindner, Manuel Röhrich, Hendrik Rathke, Hans-Ulrich Kauczor, Jürgen Debus, Uwe Haberkorn, Clemens Kratochwil

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2019

Excerpt

FDG-PET/CT is the current mainstay of lung cancer staging and presents favorable sensitivity and specificity in comparison to morphological diagnostic means especially for mediastinal lymph-node assessment. However, high physiological uptake in the brain requires additional cerebral magnetic resonance imaging to complete M-staging. Although not a major limitation, the dependency of FDG on blood sugar and the need of preparatory fasting and to recline during the 1-h uptake phase is inconvenient, hampering smooth patient workflow [1]. …

Flechsig P, Mehndiratta A, Haberkorn U, Kratochwil C, Giesel FL. PET/MRI and PET/CT in lung lesions and thoracic malignancies. Semin Nucl Med. 2015;45(4):268–81. https://doi.org/10.1053/j.semnuclmed.2015.03.004.CrossRefPubMed

Lindner T, Loktev A, Altmann A, et al. Development of quinoline-based theranostic ligands for the targeting of fibroblast activation protein. J Nucl Med. 2018;59(9):1415–22. https://doi.org/10.2967/jnumed.118.210443.CrossRefPubMed

Loktev A, Lindner T, Mier W, et al. A tumor-imaging method targeting cancer-associated fibroblasts. J Nucl Med. 2018;59(9):1423–9. https://doi.org/10.2967/jnumed.118.210435.CrossRefPubMedPubMedCentral

Giesel F, Kratochwil C, Lindner T, et al. FAPI-PET/CT: biodistribution and preliminary dosimetry estimate of two DOTA-containing FAP-targeting agents in patients with various cancers. J Nucl Med. 2019;60(3):386–392. https://doi.org/10.2967/jnumed.118.215913.

Kratochwil C, Flechsig P, Lindner T, et al. FAPI-PET/CT: mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer. J Nucl Med 2019 6. doi: https://doi.org/10.2967/jnumed.119.227967.

Title: FAPI-PET/CT improves staging in a lung cancer patient with cerebral metastasis
Authors: Frederik L. Giesel
Claus Peter Heussel
Thomas Lindner
Manuel Röhrich
Hendrik Rathke
Hans-Ulrich Kauczor
Jürgen Debus
Uwe Haberkorn
Clemens Kratochwil
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Lung Cancer
Metastasis
Lung Cancer
Lung Cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04346-z

Keynote webinar | Spotlight on sleep in brain health

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FAPI-PET/CT improves staging in a lung cancer patient with cerebral metastasis

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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