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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 5/2017

Open Access 01-05-2017 | Original Article

Left ventricular function in response to dipyridamole stress: head-to-head comparison between 82Rubidium PET and 99mTc-sestamibi SPECT ECG-gated myocardial perfusion imaging

Authors: Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares Jr., Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J. Verberne

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2017

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Abstract

Purpose

Myocardial perfusion imaging (MPI) with 99mTc-sestamibi (sestamibi) SPECT and rubidium-82 (82Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose.

Materials and methods

A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and 82Rb MPI after a single dipyridamole stress dose. Sestamibi and 82Rb summed rest (SRS), stress (SSS) and difference (SDS) scores, and LV end-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were compared.

Results

Bland-Altman analysis showed that with increasing ESV and EDV the difference between the two perfusion tracers increased both at rest and post-stress. The mean difference in EDV and ESV between the two perfusion tracers at rest could both be independently explained by the 82Rb SDS and the sestamibi SRS. The combined models explained approximately 30% of the variation in these volumes between the two perfusion tracers (R2 = 0.261, p = 0.005; R2 = 0.296, p < 0.001, for EDV and ESV respectively). However, the mean difference in LVEF between sestamibi and 82Rb showed no significant trend post-stress (R2 = 0.001, p = 0.70) and only a modest linear increase with increasing LVEF values at rest (R2 = 0.032, p = 0.009).

Conclusions

Differences in left ventricular volumes between sestamibi and 82Rb MPI increase with increasing volumes. However, these differences did only marginally affect LVEF between sestamibi and 82Rb. In clinical practice these results should be taken into account when comparing functional derived parameters between sestamibi and 82Rb MPI.
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Metadata
Title
Left ventricular function in response to dipyridamole stress: head-to-head comparison between 82Rubidium PET and 99mTc-sestamibi SPECT ECG-gated myocardial perfusion imaging
Authors
Maria Clementina Giorgi
Jose Claudio Meneghetti
Jose Soares Jr.
Marisa Izaki
Andréa Falcão
Rodrigo Imada
William Chalela
Marco Antonio de Oliveira
Cesar Nomura
Hein J. Verberne
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2017
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3588-x

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