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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2016

01-11-2016 | Image of the Month

Paraneoplastic syndrome demonstrated on 99mTc-HMDP bone scan

Authors: Sophie Lancelot, Francesco Giammarile, Agnes Tescaru

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2016

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Abstract

A 23-year-old man, with no relevant medical history, presented with inflammatory peripheral and axial polyarthritis, wrist pain, and persistent low-grade fever for the past 4 months. A bone scintigraphy showed intense periosteal early and delayed uptake in long bones, with normal uptake in the spine, pelvis, and rib cage, and no clear focus of hypermetabolism. CT scan revealed a mediastinal mass. A biopsy of the mass demonstrated Hodgkin lymphoma with bulky disease. This paraneoplastic syndrome as the first sign of intrathoracic Hodgkin’s disease is rare.
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Atkinson MK, McElwain TJ, Peckham MJ, Thomas PP. Hypertrophic pulmonary osteoarthropathy in Hodgkin’s disease: reversal with chemotherapy. Cancer. 1976;38:1729–34.CrossRefPubMed
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Vandemergel X, Blocklet D, Decaux G. Periostitis and hypertrophic osteoarthropathy: etiologies and bone scan patterns in 115 cases. Eur J Intern Med. 2004;15:375–80.CrossRefPubMed
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Ulusakarya A, Gumus Y, Brahimi N, Delmas-Marsalet B, Almohamad W, Misra SC, et al. Symptoms in cancer patients and an unusual tumor: Case 1. Regression of hypertrophic pulmonary osteoarthropathy following chemotherapy for lung metastases of a nasopharyngeal carcinoma. J Clin Oncol. 2005;23:9422–3.CrossRefPubMed
Metadata
Title
Paraneoplastic syndrome demonstrated on 99mTc-HMDP bone scan
Authors
Sophie Lancelot
Francesco Giammarile
Agnes Tescaru
Publication date
01-11-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3471-9

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