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Published in: European Journal of Nuclear Medicine and Molecular Imaging 4/2016

01-04-2016 | Original Article

A randomized, double-blind, crossover comparison of novel continuous bed motion versus traditional bed position whole-body PET/CT imaging

Authors: Imke Schatka, Desiree Weiberg, Stephanie Reichelt, Nicole Owsianski-Hille, Thorsten Derlin, Georg Berding, Frank M. Bengel

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2016

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Abstract

Purpose

Continuous bed motion has recently been introduced for whole-body PET/CT, and represents a paradigm shift towards individualized and flexible acquisition without the limitations of bed position-based planning. Increased patient comfort due to lack of abrupt table position changes may be another albeit still unproven advantage. For robust clinical implementation, image quality and quantitative accuracy should at least be equal to the prior standard of bed position-based step-and-shoot imaging.

Methods

The study included 68 consecutive patients referred for whole-body PET/CT for various malignancies. The patients underwent traditional step-and-shoot and novel continuous bed motion acquisition in the same session in a randomized crossover design. The patients and two independent observers were blinded to the sequence of scan techniques. Patient comfort/satisfaction was examined using a standardized questionnaire. SUVs were compared for reference tissue (liver, muscle) and tumour lesions. PET image quality and misalignment with CT images were evaluated on a scale of 1 – 4.

Results

Patients preferred continuous bed motion over step-and-shoot (P = 0.0001). It was considered to be more relaxing (38 % vs. 8 %), quieter (34 % vs. 8 %), and more fluid (64 % vs. 8 %). Image quality, SUV and CT misalignment did not differ between the techniques. Continuous bed motion resulted in better end-plane image quality (P < 0.0001). Regardless of the technique, second examinations had significantly higher tumour lesion SUVmax values (P = 0.0002), and a higher CT misalignment score (P = 0.0017).

Conclusion

Oncological PET/CT with continuous bed motion enhances patient comfort and is associated with image quality at least comparable to that with traditional bed position-based step-and-shoot acquisition.qq
Literature
1.
go back to reference Bengel FM, Ziegler SI, Avril N, Weber W, Laubenbacher C, Schwaiger M. Whole-body positron emission tomography in clinical oncology: comparison between attenuation-corrected and uncorrected images. Eur J Nucl Med. 1997;24:1091–8.PubMed Bengel FM, Ziegler SI, Avril N, Weber W, Laubenbacher C, Schwaiger M. Whole-body positron emission tomography in clinical oncology: comparison between attenuation-corrected and uncorrected images. Eur J Nucl Med. 1997;24:1091–8.PubMed
2.
go back to reference Dahlbom M, Hoffman EJ, Hoh CK, et al. Whole-body positron emission tomography: Part I. Methods and performance characteristics. J Nucl Med. 1992;33:1191–9.PubMed Dahlbom M, Hoffman EJ, Hoh CK, et al. Whole-body positron emission tomography: Part I. Methods and performance characteristics. J Nucl Med. 1992;33:1191–9.PubMed
3.
go back to reference Dahlbom M, Reed J, Young J. Implementation of true continuous bed motion in 2-D and 3-D whole-body PET scanning. IEEE Trans Nucl Sci. 2001;48:1465–9.CrossRef Dahlbom M, Reed J, Young J. Implementation of true continuous bed motion in 2-D and 3-D whole-body PET scanning. IEEE Trans Nucl Sci. 2001;48:1465–9.CrossRef
4.
go back to reference Ceccarini G, Flavell RR, Butelman ER, Synan M, Willnow TE, Bar-Dagan M, et al. PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab. 2009;10:148–59.PubMedCentralCrossRefPubMed Ceccarini G, Flavell RR, Butelman ER, Synan M, Willnow TE, Bar-Dagan M, et al. PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab. 2009;10:148–59.PubMedCentralCrossRefPubMed
5.
go back to reference Marik J, Tartis MS, Zhang H, Fung JY, Kheirolomoom A, Sutcliffe JL, et al. Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP). Nucl Med Biol. 2007;34:165–71.PubMedCentralCrossRefPubMed Marik J, Tartis MS, Zhang H, Fung JY, Kheirolomoom A, Sutcliffe JL, et al. Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP). Nucl Med Biol. 2007;34:165–71.PubMedCentralCrossRefPubMed
6.
go back to reference Achenbach S, Marwan M, Ropers D, Schepis T, Pflederer T, Anders K, et al. Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition. Eur Heart J. 2010;31:340–6.CrossRefPubMed Achenbach S, Marwan M, Ropers D, Schepis T, Pflederer T, Anders K, et al. Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition. Eur Heart J. 2010;31:340–6.CrossRefPubMed
7.
go back to reference Brauck K, Zenge MO, Vogt FM, Quick HH, Stock F, Trarbach T, et al. Feasibility of whole-body MR with T2- and T1-weighted real-time steady-state free precession sequences during continuous table movement to depict metastases. Radiology. 2008;246:910–6.CrossRefPubMed Brauck K, Zenge MO, Vogt FM, Quick HH, Stock F, Trarbach T, et al. Feasibility of whole-body MR with T2- and T1-weighted real-time steady-state free precession sequences during continuous table movement to depict metastases. Radiology. 2008;246:910–6.CrossRefPubMed
8.
go back to reference Braun H, Ziegler S, Lentschig MG, Quick HH. Implementation and performance evaluation of simultaneous PET/MR whole-body imaging with continuous table motion. J Nucl Med. 2014;55:161–8.CrossRefPubMed Braun H, Ziegler S, Lentschig MG, Quick HH. Implementation and performance evaluation of simultaneous PET/MR whole-body imaging with continuous table motion. J Nucl Med. 2014;55:161–8.CrossRefPubMed
9.
go back to reference Osborne DR, Acuff S, Cruise S, Syed M, Neveu M, Stuckey A, et al. Quantitative and qualitative comparison of continuous bed motion and traditional step and shoot PET/CT. Am J Nucl Med Mol Imaging. 2015;5:56–64.PubMedCentralPubMed Osborne DR, Acuff S, Cruise S, Syed M, Neveu M, Stuckey A, et al. Quantitative and qualitative comparison of continuous bed motion and traditional step and shoot PET/CT. Am J Nucl Med Mol Imaging. 2015;5:56–64.PubMedCentralPubMed
10.
go back to reference Panin VY, Smith AM, Hu J, Kehren F, Casey ME. Continuous bed motion on clinical scanner: design, data correction, and reconstruction. Phys Med Biol. 2014;59:6153–74.CrossRefPubMed Panin VY, Smith AM, Hu J, Kehren F, Casey ME. Continuous bed motion on clinical scanner: design, data correction, and reconstruction. Phys Med Biol. 2014;59:6153–74.CrossRefPubMed
11.
go back to reference Ben-Haim S, Kacperski K, Hain S, Van Gramberg D, Hutton BF, Erlandsson K, et al. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging. 2010;37:1710–21.PubMedCentralCrossRefPubMed Ben-Haim S, Kacperski K, Hain S, Van Gramberg D, Hutton BF, Erlandsson K, et al. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging. 2010;37:1710–21.PubMedCentralCrossRefPubMed
12.
go back to reference Boiselle PM, Dippolito G, Copeland J, Kang H, Ahmed M, Weeks D, et al. Multiplanar and 3D imaging of the central airways: comparison of image quality and radiation dose of single-detector row CT and multi-detector row CT at differing tube currents in dogs. Radiology. 2003;228:107–11.CrossRefPubMed Boiselle PM, Dippolito G, Copeland J, Kang H, Ahmed M, Weeks D, et al. Multiplanar and 3D imaging of the central airways: comparison of image quality and radiation dose of single-detector row CT and multi-detector row CT at differing tube currents in dogs. Radiology. 2003;228:107–11.CrossRefPubMed
13.
go back to reference Fahey F, Zukotynski K, Zurakowski D, Markelewicz R, Falone A, Vitello M, et al. Beyond current guidelines: reduction in minimum administered radiopharmaceutical activity with preserved diagnostic image quality in pediatric hepatobiliary scintigraphy. Eur J Nucl Med Mol Imaging. 2014;41:2346–53.CrossRefPubMed Fahey F, Zukotynski K, Zurakowski D, Markelewicz R, Falone A, Vitello M, et al. Beyond current guidelines: reduction in minimum administered radiopharmaceutical activity with preserved diagnostic image quality in pediatric hepatobiliary scintigraphy. Eur J Nucl Med Mol Imaging. 2014;41:2346–53.CrossRefPubMed
14.
go back to reference Pichler BJ, Wehrl HF, Judenhofer MS. Latest advances in molecular imaging instrumentation. J Nucl Med. 2008;49 Suppl 2:5S–23. Pichler BJ, Wehrl HF, Judenhofer MS. Latest advances in molecular imaging instrumentation. J Nucl Med. 2008;49 Suppl 2:5S–23.
15.
go back to reference Achenbach S, Marwan M, Schepis T, Pflederer T, Bruder H, Allmendinger T, et al. High-pitch spiral acquisition: a new scan mode for coronary CT angiography. J Cardiovasc Comput Tomogr. 2009;3:117–21.CrossRefPubMed Achenbach S, Marwan M, Schepis T, Pflederer T, Bruder H, Allmendinger T, et al. High-pitch spiral acquisition: a new scan mode for coronary CT angiography. J Cardiovasc Comput Tomogr. 2009;3:117–21.CrossRefPubMed
16.
go back to reference Kalender WA, Seissler W, Klotz E, Vock P. Spiral volumetric CT with single-breath-hold technique, continuous transport, and continuous scanner rotation. Radiology. 1990;176:181–3.CrossRefPubMed Kalender WA, Seissler W, Klotz E, Vock P. Spiral volumetric CT with single-breath-hold technique, continuous transport, and continuous scanner rotation. Radiology. 1990;176:181–3.CrossRefPubMed
17.
go back to reference Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50 Suppl 1:122S–50. Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50 Suppl 1:122S–50.
18.
go back to reference Weber WA, Gatsonis CA, Mozley PD, Hanna LG, Shields AF, Aberle DR, et al. Repeatability of 18F-FDG PET/CT in advanced non-small cell lung cancer: prospective assessment in 2 multicenter trials. J Nucl Med. 2015;56:1137–43.CrossRefPubMed Weber WA, Gatsonis CA, Mozley PD, Hanna LG, Shields AF, Aberle DR, et al. Repeatability of 18F-FDG PET/CT in advanced non-small cell lung cancer: prospective assessment in 2 multicenter trials. J Nucl Med. 2015;56:1137–43.CrossRefPubMed
19.
go back to reference Cherry SR, Dahlbom M, Hoffman EJ. 3D PET using a conventional multislice tomograph without septa. J Comput Assist Tomogr. 1991;15:655–68.CrossRefPubMed Cherry SR, Dahlbom M, Hoffman EJ. 3D PET using a conventional multislice tomograph without septa. J Comput Assist Tomogr. 1991;15:655–68.CrossRefPubMed
20.
go back to reference Everding M, Emery D, Mawlawi O, Millican-Campbell R, Palendat T, Pan T, et al. Impact of continuous bed motion (CBM) PET/CT scanners on clinical operation (abstract). J Nucl Med. 2014;55 Suppl 1:2511. Everding M, Emery D, Mawlawi O, Millican-Campbell R, Palendat T, Pan T, et al. Impact of continuous bed motion (CBM) PET/CT scanners on clinical operation (abstract). J Nucl Med. 2014;55 Suppl 1:2511.
21.
go back to reference Lodge MA, Chaudhry MA, Wahl RL. Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med. 2012;53:1041–7.PubMedCentralCrossRefPubMed Lodge MA, Chaudhry MA, Wahl RL. Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med. 2012;53:1041–7.PubMedCentralCrossRefPubMed
22.
go back to reference Acuff SN, Bradley YC, Barlow P, Osborne DR. Reduction of patient anxiety in PET/CT imaging by improving communication between patient and technologist. J Nucl Med Technol. 2014;42:211–7.CrossRefPubMed Acuff SN, Bradley YC, Barlow P, Osborne DR. Reduction of patient anxiety in PET/CT imaging by improving communication between patient and technologist. J Nucl Med Technol. 2014;42:211–7.CrossRefPubMed
Metadata
Title
A randomized, double-blind, crossover comparison of novel continuous bed motion versus traditional bed position whole-body PET/CT imaging
Authors
Imke Schatka
Desiree Weiberg
Stephanie Reichelt
Nicole Owsianski-Hille
Thorsten Derlin
Georg Berding
Frank M. Bengel
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-015-3226-z

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