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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-06-2011 | Review Article

A new dimension of FDG-PET interpretation: assessment of tumor biology

Authors: Thomas C. Kwee, Sandip Basu, Babak Saboury, Valentina Ambrosini, Drew A. Torigian, Abass Alavi

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2011

Abstract

¹⁸F-Fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) is increasingly being used for the evaluation of several malignancies. Key to the correct interpretation of oncological FDG-PET studies is awareness of the concept that the degree of FDG uptake reflects the biology of the tumor in many cancers. More specifically, cancers with high FDG uptake are often histologically and clinically more aggressive than those with low or no FDG uptake. Therefore, although a negative FDG-PET scan in a patient with a cancer that has a size above the spatial resolution of PET may be interpreted as false-negative in terms of tumor detectability, it should in fact be regarded as true-negative from the view-point of tumor biology. This nonsystematic review will give examples of several major cancers in which the relationship between FDG avidity and tumor biology is applicable, and emphasizes the need to reconsider the definition of a “false-negative” FDG-PET scan in clinical oncology.

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Title: A new dimension of FDG-PET interpretation: assessment of tumor biology
Authors: Thomas C. Kwee
Sandip Basu
Babak Saboury
Valentina Ambrosini
Drew A. Torigian
Abass Alavi
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-010-1713-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A new dimension of FDG-PET interpretation: assessment of tumor biology

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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