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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 6/2009

01-06-2009 | Original Article

Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification

Authors: Laure Joly, Wassila Djaballah, Gregory Koehl, Damien Mandry, Gilles Dolivet, Pierre-Yves Marie, Athanase Benetos

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2009

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Abstract

Purpose

To analyse the relationship between: (i) aortic pulse wave velocity (PWV), an index of aortic stiffness with strong prognostic significance, and (ii) aortic calcification and inflammation, which were quantified by hybrid imaging with X-ray computed tomography (CT) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET).

Methods

Central aortic (carotid-femoral) and peripheral (carotid-brachial and femoral-tibial) PWV were recorded in 26 patients, who had been routinely referred for dual FDG-PET/CT imaging.

Results

In univariate analyses, central aortic PWV was strongly linked to the volume of calcifications (VCa) and an enhanced FDG activity, when determined by averaging standardized uptake values (SUVmax). By multivariate stepwise analysis including age and gender, both VCa (p < 0.0001) and SUVmax (p < 0.01) were significant determinants of PWV explaining 61% and 11% of its variability.

Conclusion

Aortic inflammation, assessed by hybrid FDG-PET/CT imaging, is associated with an enhanced aortic stiffness, in addition to the concurrent impact of calcifications.
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Metadata
Title
Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification
Authors
Laure Joly
Wassila Djaballah
Gregory Koehl
Damien Mandry
Gilles Dolivet
Pierre-Yves Marie
Athanase Benetos
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-1047-z

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