Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 6/2009

Open Access 01-06-2009 | Original Article

Kinetic models for analysing myocardial [11C]palmitate data

Authors: Hugo W. A. M. de Jong, Luuk J. Rijzewijk, Mark Lubberink, Rutger W. van der Meer, Hildo J. Lamb, Jan W. A. Smit, Michaëla Diamant, Adriaan A. Lammertsma

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2009

Login to get access

Abstract

Purpose

[11C]Palmitate PET can be used to study myocardial fatty acid metabolism in vivo. Several models have been applied to describe and quantify its kinetics, but to date no systematic analysis has been performed to define the most suitable model.

Methods

In this study a total of 21 plasma input models comprising one to three compartments and up to six free rate constants were compared using statistical analysis of clinical data and simulations. To this end, 14 healthy volunteers were scanned using [11C]palmitate, whilst myocardial blood flow was measured using H2 15O.

Results

Models including an oxidative pathway, representing production of 11CO2, provided significantly better fits to the data than other models. Model robustness was increased by fixing efflux of 11CO2 to the oxidation rate. Simulations showed that a three-tissue compartment model describing oxidation and esterification was feasible when no more than three free rate constants were included.

Conclusion

Although further studies in patients are required to substantiate this choice, based on the accuracy of data description, the number of free parameters and generality, the three-tissue model with three free rate constants was the model of choice for describing [11C]palmitate kinetics in terms of oxidation and fatty acid accumulation in the cell.
Literature
1.
Miyabe H, Ohte N, Iida A, Narita H, Yoshida T, Kimura G. Evaluation of fatty acid beta-oxidation in patients with prior myocardial infarction in relation to myocardial blood flow, total oxidative metabolism, and left ventricular wall motion. Circ J. 2005;69:1459–65.PubMedCrossRef
2.
Phelps ME, Mazziotta JC, Schelbert HR. Positron emission tomography and autoradiography (Principles and applications for the brain and heart). New York: Raven; 1986.
3.
Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916.PubMedCrossRef
4.
Klein LJ, Visser FC, Knaapen P, Peters JH, Teule GJJ, Visser CA, et al. Carbon-11 acetate as a tracer of myocardial oxygen consumption. Eur J Nucl Med. 2001;28:651–68.PubMedCrossRef
5.
Schelbert HR, Henze E, Sochor H, Grossman RG, Huang SC, Barrio JR, et al. Effects of substrate availability on myocardial C-11 palmitate kinetics by positron emission tomography in normal subjects and patients with ventricular dysfunction. Am Heart J. 1986;111:1055–64.PubMedCrossRef
6.
Sciacca RR, Akinboboye O, Ling Chou R, Epstein S, Bergmann SR. Measurement of myocardial blood flow with PET using 1-11C-acetate. J Nucl Med. 2001;42:63–70.PubMed
7.
Sun KT, Yeatman LA, Buxton DB, Chen K, Johnson JA, Huang SC, et al. Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate. J Nucl Med. 1998;39:272–80.PubMed
8.
van der Vusse GJ, Glatz JF, Stam HC, Reneman RS. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev. 1992;72:881–940.PubMed
9.
Bergmann SR, Weinheimer CJ, Markham J, Herrero P. Quantitation of myocardial fatty acid metabolism using PET. J Nucl Med. 1996;37:1723–30.PubMed
10.
Knuuti J, Takala TO, Nagren K, Sipila H, Turpeinen AK, Uusitupa MI, et al. Myocardial fatty acid oxidation in patients with impaired glucose tolerance. Diabetologia 2001;44:184–7.PubMedCrossRef
11.
Goldstein RA, Klein MS, Welch MJ, Sobel BE. External assessment of myocardial metabolism with C-11 palmitate in vivo. J Nucl Med. 1980;21:342–8.PubMed
12.
Bergmann SR, Herrero P, Sciacca R, Hartman JJ, Rubin PJ, Hickey KT, et al. Characterization of altered myocardial fatty acid metabolism in patients with inherited cardiomyopathy. J Inherit Metab Dis. 2001;24:657–74.PubMedCrossRef
13.
Welch MJ, Dence CS, Marshall DR, Killbourn MR. Remote system for production of carbon-11 labelled palmitic acid. J Lab Comp Radiopharm. 1983;20:1087–95.CrossRef
14.
Brix G, Zaers J, Adam LE, Bellemann ME, Ostertag H, Trojan H, et al. Performance evaluation of a whole-body PET scanner using the NEMA protocol. J Nucl Med. 1997;38:1614–23.PubMed
15.
Adam LE, Zaers J, Ostertag H, Trojan H, Bellemann ME, Brix G. Performance evaluation of the whole-body PET scanner ECAT exact HR+ following the IEC standard. IEEE Trans Nucl Sci. 1997;44:1172–9.CrossRef
16.
De Jong HWAM, Lubberink M. Issues in quantification of cardiac PET studies. Eur J Nucl Med Mol Imaging. 2007;34:316–9.PubMedCrossRef
17.
Knaapen P, Boellaard R, Gotte MJW, Dijkmans PA, van Campen LMC, de Cock CC, et al. Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy. J Nucl Med. 2004;45:1299–304.PubMed
18.
Hermansen F, Rosen SD, Fath-Ordoubadi F, Kooner JS, Clark JC, Camici PG, et al. Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols. Eur J Nucl Med. 1998;25:751–9.PubMedCrossRef
19.
Degrado TR, Holden JE, Ng CK, Raffel DM, Gatley SJ. Quantitative-analysis of myocardial kinetics of 15-P-[Iodine-125] iodophenylpentadecanoic acid. J Nucl Med. 1989;30:1211–8.PubMed
20.
More JJ. The Levenberg-Marquardt algorithm: implementation and theory, numerical analysis. In: Watson GA, editor. Lecture notes in mathematics 630. Springer Verlag; 1977. pp. 105–116.
21.
Muzi M, Mankoff DA, Grierson JR, Wells JM, Vesselle H, Krohn KA. Kinetic modeling of 3′-deoxy-3′-fluorothymidine in somatic tumors mathematical studies. J Nucl Med. 2005;46:371–80.PubMed
22.
Mankoff DA, Shields AF, Graham MM, Link JM, Eary JF, Krohn KA. Kinetic analysis of 2-[carbon-11]thymidine PET imaging studies: compartmental model and mathematical analysis. J Nucl Med. 1998;39:1043–55.PubMed
23.
Arai T, Wakabayashi SI, Channing MA, Dunn BB, Der MG, Bell JM, et al. Incorporation of [1-carbon-11]palmitate in monkey brain using PET. J Nucl Med. 1995;36:2261–7.PubMed
24.
Geltman EM. Assessment of myocardial fatty acid metabolism with 1-11C-palmitate. J Nucl Cardiol. 1994;1:S15–22.PubMedCrossRef
25.
Gunn RN, Sargent PA, Bench CJ, Rabiner EA, Osman S, Pike VW, et al. Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. Neuroimage 1998;8:426–40.PubMedCrossRef
26.
Lammertsma AA. Radioligand studies: imaging and quantitative analysis. Eur Neuropsychopharmacol 2002;12:513–6.PubMedCrossRef
27.
Kropholler MA, Boellaard R, Schuitemaker A, Folkersma H, van Berckel BNM, Lammertsma AA. Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies. J Cereb Blood Flow Metab. 2006;26:1431–41.PubMedCrossRef
28.
Brooks DJ, Lammertsma AA, Beaney RP, Leenders KL, Buckingham PD, Marshall J, et al. Measurement of regional cerebral pH in human subjects using continuous inhalation of 11CO2 and positron emission tomography. J Cereb Blood Flow Metab. 1984;4:458–65.PubMed
29.
Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res. 2001;50:151–61.PubMedCrossRef
Metadata
Title
Kinetic models for analysing myocardial [11C]palmitate data
Authors
Hugo W. A. M. de Jong
Luuk J. Rijzewijk
Mark Lubberink
Rutger W. van der Meer
Hildo J. Lamb
Jan W. A. Smit
Michaëla Diamant
Adriaan A. Lammertsma
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-1035-3

Other articles of this Issue 6/2009

European Journal of Nuclear Medicine and Molecular Imaging 6/2009 Go to the issue

Original Article

Chronic thyroiditis in patients with advanced breast carcinoma: metabolic and morphologic changes on PET-CT

Original Article

Posttherapeutic 131I SPECT-CT offers high diagnostic accuracy when the findings on conventional planar imaging are inconclusive and allows a tailored patient treatment regimen

Focus on

Amyloid imaging with PET: methodological issues and correlative studies

Original Article

The value of FDG-PET/CT in assessing single pulmonary nodules in patients at high risk of lung cancer

Original article

Cardiac resynchronization therapy evaluated by myocardial scintigraphy with 99mTc-MIBI: changes in left ventricular uptake, dyssynchrony, and function

Image of the Month

Demonstration of metastatic tumour growth following vessel structures by PET/CT