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European Journal of Nuclear Medicine and Molecular Imaging

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01-01-2009 | Short Communication

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in ⁶⁸Ga-DOTATOC PET/CT

Authors: Matthias Miederer, Stefan Seidl, Andreas Buck, Klemens Scheidhauer, Hans-Jürgen Wester, Markus Schwaiger, Aurel Perren

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 1/2009

Abstract

Purpose

In clinical routine somatostatin analogue positron emission tomography/computed tomography (PET/CT) such as ⁶⁸Ga-DOTA-Tyr-octreotide (DOTATOC)-PET/CT could substitute conventional ¹¹¹In-Octreotide scintigraphy. Immunohistochemistry (IHC) for somatostatin receptor 2 (SSTR2) might be a tool to predict positivity of ⁶⁸Ga-DOTATOC in patients where initial staging was not performed, e.g., in incidental findings. We therefore compared a score of SSTR2-IHC with the in vivo standard uptake value (SUV) of preoperative or prebiopsy ⁶⁸Ga-DOTATOC PET/CT.

Materials and methods

In 18 patients, ⁶⁸Ga-DOTATOC PET/CT scans were quantified with SUV calculations and correlated to a cell membrane-based SSTR2-IHC score (ranging from 0 to 3).

Results

Negative IHC scores were consistent with SUV values below 10. Furthermore, all score 2 and 3 specimens corresponded with high SUV values (above 15).

Conclusion

SSTR2-IHC scores correlated well with SUV values and we propose to use SSTR2 immunohistochemistry in patients missing a preoperative PET scan to indicate ⁶⁸Ga-DOTATOC-PET/CT as method for restaging and follow-up in individual patients.

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Title: Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT
Authors: Matthias Miederer
Stefan Seidl
Andreas Buck
Klemens Scheidhauer
Hans-Jürgen Wester
Markus Schwaiger
Aurel Perren
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 1/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0944-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in ⁶⁸Ga-DOTATOC PET/CT

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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