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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 2/2008

01-02-2008 | Original Article

Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with 18F-FEDAA1106

Authors: Miho Shidahara, Yoko Ikoma, Chie Seki, Yota Fujimura, Mika Naganawa, Hiroshi Ito, Tetsuya Suhara, Iwao Kanno, Yuichi Kimura

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2008

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Abstract

Purpose

We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k 3/k 4) of the peripheral benzodiazepine receptor using 18F-FEDAA1106 and nonlinear least-square fitting.

Methods

Wavelet denoising within a three-dimensional discrete dual-tree complex wavelet transform was applied to simulate data and clinical dynamic positron emission tomography images of 18F-FEDAA1106. To eliminate noise components in wavelet coefficients, real and imaginary coefficients for each subband were thresholded individually using NormalShrink. A simulated dynamic brain image of 18F-FEDAA1106 was generated and Gaussian noise was added to mimic PET dynamic scan. The derived BP images were compared with true images using 156 rectangular regions of interest. Wavelet denoising was also applied to data derived from seven young normal volunteers.

Results

In the simulations, estimated BP by denoised image showed better correlation with the true BP values (Y = 0.83X + 0.94, r = 0.80), although no correlation was observed in the estimates between noise-added and true images (Y = 1.2X + 0.78, r = 0.49). For clinical data, there were visual improvements in the signal-to-noise ratio for estimated BP images.

Conclusions

Wavelet denoising improved the bias and reduced the variation of pharmacokinetic parameters for BP.
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Metadata
Title
Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with 18F-FEDAA1106
Authors
Miho Shidahara
Yoko Ikoma
Chie Seki
Yota Fujimura
Mika Naganawa
Hiroshi Ito
Tetsuya Suhara
Iwao Kanno
Yuichi Kimura
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-007-0623-y

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